AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE

Product Name: AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE
CAS No.: 131602-53-4
Chemical Name: AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE
Synonyms: Aβ25-35;BETA-AMYLOID;GSNKGAIIGLM;-Amyloid(25-35);β-Amyloid (25-35);BETA-AMYLOID (25-35);β-Amyloid (25-35) TFA;25-35) TRIFLUOROACETATE;β-Amyloid peptide(25-35);AMyloid b-Protein (25-35)
CBNumber: CB7297245
Molecular Formula: C45H81N13O14S
Formula Weight: 1060.27
MOL File: 131602-53-4.mol

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AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE Property

Boiling point:: 1517.3±65.0 °C(Predicted)
Density: 1.248±0.06 g/cm3(Predicted)
RTECS: BU7435200
storage temp.: -20°C
solubility: insoluble in EtOH; insoluble in H2O; ≥106 mg/mL in DMSO
pka: 3.24±0.10(Predicted)
form: Lyophilized.
color: Lyophilized White
Water Solubility: Soluble in water.
Sequence: H-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-OH
InChIKey: WIHBNMPFWRHGDF-SLVFWPMISA-N

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Safety

WGK Germany: 3
HS Code: 2930909899

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A4559
Product name: Amyloid β-Protein Fragment 25-35
Purity: ≥97% (HPLC)
Packaging: 250μg
Price: $53.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: A4559
Product name: Amyloid β-Protein Fragment 25-35
Purity: ≥97% (HPLC)
Packaging: 1mg
Price: $224
Updated: 2024/03/01

Alfa Aesar

Product number: J66808
Product name: Amyloid beta (25-35)
Packaging: 1mg
Price: $112
Updated: 2023/06/20

Tocris

Product number: 1429
Product name: Amyloidbeta-peptide(25-35)(human)
Packaging: 1
Price: $210
Updated: 2021/12/16

Usbiological

Product number: A2275-58K
Product name: β-Amyloid
Packaging: 5mg
Price: $396
Updated: 2021/12/16

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AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE Chemical Properties,Usage,Production

Description

Beta-amyloid protein (Abeta), a major component of senile plaques of Alzheimer's disease (AD) in the brain, causes elevation of the intracellular free Ca2+ level and the production of robust free radicals. Beta-amyloid 25-35 induced apoptosis, characterized by decreased cell viability, neuronal DNA condensation, and fragmentation, is associated with an increase in intracellular free Ca2+ level, the accumulation of reactive oxygen species (ROS), and the activation of caspase-3. All of these effects induced by beta-amyloid 25-35 are reversed by genistein.

Uses

Amyloid β-Protein Fragment 25-35 has been used:

to induce neurotoxicity in cortical cultures
to induce Alzheimer′s disease in rat model
to induce apoptosis in mesenchymal stem cells (MSCs)

General Description

Amyloid β-Protein Fragment 25-35 (Aβ25-35) is derived from the amyloid-β protein.amyloid-β protein, which is mapped to human chromosome 21q21. Aβ25-35 lacks the N-terminal domain and the metal binding site and is majorly generated by proteolytic cleavage of Aβ(1?40) peptides. It has a β-sheet and β-turn structure.

Biological Activity

Amyloid β-peptide (25-35) (human) is a fragment of human amyloid β-peptide, functionally required for the neurotrophic and neurotoxic effects associated with Alzheimer's disease.

Biochem/physiol Actions

Amyloid β-Protein Fragment 25-35 (Aβ25-35) is involved in the pathogenesis of Alzheimer′s disease. Inhibitors of this transition may serve as a potential agent in managing Alzheimer′s disease. It is present in the subiculum and entorhinal cortex neurons of Alzheimer′s brain samples and inclusion-body myositis (IBM) muscle. It binds to receptors present in microglia and is capable of lipid membrane insertion. The functional domain sequence of Aβ comprising of sequence GSNKGAIIGLM elicits neurotrophic and neurotoxic effects. Aβ25-35 exhibits rapid aggregation and displays age dependant neurotoxicity.

Mechanism of action

Amyloid β (Aβ) peptide is a proven major contributing component of neuritic plaques of Alzheimer's disease (AD) . The formation of fibrillar deposits of Aβ peptide in brain is a key step in the pathogenesis of this disease, since the conversion of Aβ from soluble monomer to insoluble fibril is considered to cause the neuronal degeneration and clinical dementia in AD patients. Recent biophysical studies such as electron microscopy, solid-state NMR, Fourier transform infrared (FTIR), and electronic circular dichroism (ECD) spectra indicated that the Aβ fibrils exhibit a high β-sheet content. The conversion of normal Aβ peptides with water-soluble α-helical/random coil structures into the insoluble Aβ aggregates with an extensive β-sheet content is considered to be the predominant event in the onset of AD.

storage

-20°C

AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE Preparation Products And Raw materials

Raw materials

Preparation Products

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AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE Suppliers

China 142 Europe 1 France 1 Germany 6 Japan 3 Switzerland 2 United Kingdom 6 United States 24 Global 185

MedChemexpress LLC

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View Lastest Price from AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd

Product: β-Amyloid (25-35) 131602-53-4
Price: US $0.10-0.30/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 20 tons
Release date: 2024-01-05

Hebei Mojin Biotechnology Co., Ltd

Product: AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE 131602-53-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-28

Career Henan Chemical Co

Product: AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE 131602-53-4
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-13

131602-53-4, AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATERelated Search:

H-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-OH Amyloid beta-Protein (17-40) ammonium salt AMYLOID BETA-PROTEIN (1-40) (MOUSE, RAT) Amyloid β-Protein (3-40) Amyloid Beta-Protein (1-14) H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH Amyloid β-Protein (4-42) H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-OH H-MET-LEU-GLY-ILE-ILE-ALA-GLY-LYS-ASN-SER-GLY-OH BETA-AMYLOID (1-43) AMYLOID BETA-PROTEIN (40-1) Amyloid β-Protein (1-6) H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-VAL-GLY-GLY-VAL-VAL-ILE-ALA-THR-VAL-ILE-VAL-OH Amyloid β-Protein (3-42) H-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-OH AMYLOID BETA-PROTEIN (6-20) H-LYS-LEU-VAL-PHE-PHE-OH H-ILE-ILE-GLY-LEU-MET-OH

Amyloid beta-peptide(25-35)

AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE

H-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-OH

AMYLOID BETA-PEPTIDE (25-35) (HUMAN)

AMYLOID BETA-PROTEIN FRAGMENT 25-35

AMYLOID BETA-PROTEIN (25-35)

AMYLOID-BETA PROTEIN (25-35), HUMAN, MOUSE, RAT

Amyloid beta-Protein (25-35) trifluoroacetate salt

GSNKGAIIGLM

GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET

GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET TRIFLUOROACETATE

BETA-AMYLOID (25-35)

BETA-AMYLOID PEPTIDE [25-35], HUMAN

BETA-AMYLOID, FRAGMENT 25-35

BETA-AMYLOID

amyloid B-protein fragment 25-35

Amyloidb-Peptide(25-35)(human)

-Amyloid(25-35)

amyloid β-protein fragment 25-35

Amyloid β-peptide (25-35) (human)

AMyloid beta (25-35) huMan

AMyloid b-Protein (25-35)

25-35) TRIFLUOROACETATE

AMYLOID BETA-PROTEIN (HUMAN

M.W. 1060.27 C45H81N13O14S

AC-ASN-TRP-CYS-LYS-ARG-GLY-ARG-LYS-GLN-CYS-LYS-THR-HIS-PRO-HIS-NH2: AC-NWCKRGRKQCKTHPH-NH2

1: PN: US20030114510 SEQID

Human beta-amyloid peptide(25-35)

L-Methionine,glycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-

Glycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-methionine

Aβ25-35

β-Amyloid peptide(25-35)

Amyloid beta-Protein Fragment 25-35 >=97% (HPLC)

β-Amyloid (25-35)

AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE USP/EP/BP

β-Amyloid (25-35) TFA

AMyloid β-peptide (25-35) (huMan)

Amyloid β-Protein Fragment 25-35

GSNKGAIIGLM(131602 53 4(free base)),GSNKGAIIGLM(131602534(free base))

β-amyloid peptide,Abeta,inhibit,Inhibitor,Amyloid-β,βAmyloid (2535),β Amyloid (25 35)

Amyloid β-Protein (25-35) trifluoroacetate salt

biotinylated?，Biotin-GSNKGAIIGLM

AMyloid β-peptide (25-35) (huMan)TFA

β-Amyloid (25-35) (human)

131602-53-4

1932-21-1

C45H81N13O14S1

C45H81N13O14S

C48H81N13O14S

Neurodegenerative Disease Peptides

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Alzheimers and Neurodegenerative Disease Research

Amyloid beta Protein Fragments