L-LEUCIC ACID
- Product Name
- L-LEUCIC ACID
- CAS No.
- 13748-90-8
- Chemical Name
- L-LEUCIC ACID
- Synonyms
- Hydroxyisocaproic acid;2-HYDROXY-3-METHYLPENTANOIC ACID;LEUCIC ACID;2-HYDROXY-3-METHYLVALERIC ACID;(s)-pentanoicaci;(S)-(-)-2-HYDROXYISOCAPROIC ACID;L-HICA;L-LEUCIC ACID;(S)-Leucic acid;L-LeucicAcid>
- CBNumber
- CB7298813
- Molecular Formula
- C6H12O3
- Formula Weight
- 132.16
- MOL File
- 13748-90-8.mol
L-LEUCIC ACID Property
- Melting point:
- 78-80 °C(lit.)
- Boiling point:
- 277.83°C (rough estimate)
- Density
- 1.0160 (rough estimate)
- refractive index
- -26 ° (C=2, 1 %NaOH)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Aqueous Base (Slightly), DMSO (Sparingly), Water (Slightly)
- pka
- 3.86±0.21(Predicted)
- form
- Solid
- color
- White to Off-White
- optical activity
- [α]22/D 26.3°, c = 1 in 1 M NaOH
- Water Solubility
- almost transparency
- InChI
- InChI=1S/C6H12O3/c1-4(2)3-5(7)6(8)9/h4-5,7H,3H2,1-2H3,(H,8,9)/t5-/m0/s1
- InChIKey
- LVRFTAZAXQPQHI-YFKPBYRVSA-N
- SMILES
- C(O)(=O)[C@@H](O)CC(C)C
- LogP
- 0.710
- CAS DataBase Reference
- 13748-90-8(CAS DataBase Reference)
- EPA Substance Registry System
- Pentanoic acid, 2-hydroxy-4-methyl-, (2S)- (13748-90-8)
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- HS Code
- 29181990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 219827
- Product name
- (S)-(?)-2-Hydroxyisocaproic acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $51.89
- Updated
- 2025/07/31
- Product number
- L0026
- Product name
- L-Leucic Acid
- Purity
- >99.0%(T)
- Packaging
- 1g
- Price
- $29
- Updated
- 2025/07/31
- Product number
- L0026
- Product name
- L-Leucic Acid
- Purity
- >99.0%(T)
- Packaging
- 5g
- Price
- $69
- Updated
- 2025/07/31
- Product number
- L0026
- Product name
- L-Leucic Acid
- Purity
- >99.0%(T)
- Packaging
- 25g
- Price
- $224
- Updated
- 2025/07/31
- Product number
- L330085
- Product name
- L-Leucic Acid
- Packaging
- 1g
- Price
- $65
- Updated
- 2021/12/16
L-LEUCIC ACID Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powde
Uses
L-Leucic Acid is a reagent in the synthesis of cryptophycins based macrocyclic depsipeptides which are used as tubulin inhibitors.
Definition
ChEBI: The (S)-enantiomer of 2-hydroxy-4-methylpentanoic acid. Derived from the metabolism of the branched-chain amino acids, it belongs to the 2-hydroxycarboxylic acid group of amino acid metabolites.
Synthesis
61-90-5
13748-90-8
GENERAL STEPS: L-leucine (24.92 g, 0.189 mol) was dissolved in 1.25 M H2SO4 (125 mL), stirred and cooled to 0°C. An aqueous solution of sodium nitrite (19.73 g, 0.286 mol) (100 mL) was added dropwise with stirring. After addition, the reaction mixture was continued to be stirred at 0°C for 2 hours, and then brought to room temperature and stirred for 15 hours. After completion of the reaction, the reaction mixture was extracted with ether (6 x 75 mL). The organic layers were combined, dried with anhydrous MgSO4, filtered and concentrated under reduced pressure to remove the ether to give the crude product L-α-hydroxyisocaproic acid (2c or 2d). The crude product was purified by solvent recrystallization from hexane-ether mixture.
IC 50
Microbial Metabolite; Human Endogenous Metabolite
References
[1] Organic Letters, 2012, vol. 14, # 16, p. 4246 - 4249
[2] Organic Letters, 2006, vol. 8, # 14, p. 2993 - 2996
[3] European Journal of Organic Chemistry, 2009, # 31, p. 5390 - 5405
[4] ACS Chemical Neuroscience, 2013, vol. 4, # 8, p. 1204 - 1216
[5] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993, # 1, p. 11 - 14
L-LEUCIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
L-LEUCIC ACID Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from L-LEUCIC ACID manufacturers
- Product
- L-LEUCIC ACID 13748-90-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-26
- Product
- 2-Hydroxy-2-methylbutyric acid 13748-90-8
- Price
- US $20.00/KG
- Min. Order
- 10KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-08-02