2,3-DIHYDRO-4-BENZOFURANAMINE

Product Name: 2,3-DIHYDRO-4-BENZOFURANAMINE
CAS No.: 61090-37-7
Chemical Name: 2,3-DIHYDRO-4-BENZOFURANAMINE
Synonyms: 2,3-dihyro-4-benzofuranamine;4-Amino-2,3-dihydrobenzofuran;2,3-dihydrobenzofuran-4-aMine;2,3-DIHYDRO-4-BENZOFURANAMINE;2,3-Dihydro-4-aminobenzofuran;4-Benzofuranamine, 2,3-dihydro-;2,3-Dihydro-1-benzofuran-4-amine;2,3-Dihydro-1-benzofuran-4-ylamine;5H,6H,7H,7aH-cyclopenta[b]pyran-5-aMine;2,3-dihydrobenzofuran-4-amine hydrochloride
CBNumber: CB7300400
Molecular Formula: C8H9NO
Formula Weight: 135.16
MOL File: 61090-37-7.mol

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2,3-DIHYDRO-4-BENZOFURANAMINE Property

Boiling point:: 268.5±29.0 °C(Predicted)
Density: 1.208±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 3.94±0.20(Predicted)
Appearance: Off-white to light brown Solid
InChI: InChI=1S/C8H9NO/c9-7-2-1-3-8-6(7)4-5-10-8/h1-3H,4-5,9H2
InChIKey: RWPLKRGISDOAAG-UHFFFAOYSA-N
SMILES: O1C2=CC=CC(N)=C2CC1

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Safety

HS Code: 2932990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FD42290
Product name: 2,3-Dihydrobenzofuran-4-amine
Packaging: 250mg
Price: $95
Updated: 2021/12/16

AK Scientific

Product number: W7338
Product name: 2,3-Dihydrobenzofuran-4-amine
Packaging: 100mg
Price: $104
Updated: 2021/12/16

Apolloscientific

Product number: OR930204
Product name: 2,3-Dihydro-4-benzofuranamine
Purity: 95%
Packaging: 250mg
Price: $160
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD42290
Product name: 2,3-Dihydrobenzofuran-4-amine
Packaging: 500mg
Price: $160
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD42290
Product name: 2,3-Dihydrobenzofuran-4-amine
Packaging: 50mg
Price: $40
Updated: 2021/12/16

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2,3-DIHYDRO-4-BENZOFURANAMINE Chemical Properties,Usage,Production

Synthesis

76093-72-6

61090-37-7

Synthesis of 4-amino-2,3-dihydrobenzofuran (1c): compound 1b (4.10 g, 16.3 mmol) was dissolved in 48% aqueous hydrobromic acid solution (20.0 mL) and mixed with thorough stirring. The reaction mixture was heated to reflux at 110°C for 16 hours. Upon completion of the reaction, the mixture was cooled to room temperature, followed by the slow addition of sodium hydroxide pellets in an ice bath at 0°C to adjust the pH to about 9. The reaction mixture was extracted several times with ethyl acetate (50 mL × 4). The organic phases were combined, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to give the crude product. Purification of the crude product by medium pressure column chromatography (Smart Flash EPCLC W-Prep 2XY system, eluent: hexane/ethyl acetate = 1/1) afforded 4-amino-2,3-dihydrobenzofuran (Compound 1c) (1.49 g, 11.0 mmol, 67.7% yield) as a colorless solid. tlc Rf = 0.30 (unfolding agent: Hexane/ethyl acetate = 1/1).1H NMR (400 MHz, CDCl3) δ 6.94 (dd, J = 8.4, 8.4 Hz, 1H), 6.28 (dd, J = 0.4, 7.6 Hz, 1H), 6.23 (dd, J = 0.4, 7.6 Hz, 1H), 4.59 (t, J = 8.4 Hz, 2H), 3.60 ( br s, 2H), 3.02 (t, J = 8.4 Hz, 2H).

References

[1] Patent: EP2881397, 2015, A1. Location in patent: Paragraph 0053; 0058; 0059
[2] Patent: US2016/303089, 2016, A1. Location in patent: Paragraph 0161; 0168; 0169; 0170; 0171
[3] Patent: US2008/318941, 2008, A1. Location in patent: Page/Page column 39
[4] Patent: WO2009/23844, 2009, A2. Location in patent: Page/Page column 127-128
[5] Patent: US2008/200471, 2008, A1. Location in patent: Page/Page column 60; 61-62

2,3-DIHYDRO-4-BENZOFURANAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,3-DIHYDRO-4-BENZOFURANAMINE Suppliers

China 60 India 2 United Kingdom 2 United States 8 Global 72

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61090-37-7