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Prucalopride

Product Name
Prucalopride
CAS No.
179474-81-8
Chemical Name
Prucalopride
Synonyms
CS-219;Resolor;R093877;R 093877;Prucalopride;Unii-0A09iuw5tp;Prucalopride, >=98%;Prucalopride(R-93877);Prucalopride USP/EP/BP;Prucalopride (R-108512, R-93877)
CBNumber
CB21179613
Molecular Formula
C18H26ClN3O3
Formula Weight
367.87
MOL File
179474-81-8.mol
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Prucalopride Property

Melting point:
90.7°
Boiling point:
481.4±45.0 °C(Predicted)
Density 
1.28
storage temp. 
2-8°C
solubility 
DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml
pka
13.65±0.20(Predicted)
form 
powder
color 
white to beige
InChI
InChI=1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23)
InChIKey
ZPMNHBXQOOVQJL-UHFFFAOYSA-N
SMILES
O1C2=C(C(NC3CCN(CCCOC)CC3)=O)C=C(Cl)C(N)=C2CC1
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Safety

RIDADR 
UN 3077 9 / PGIII
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1371
Product name
Prucalopride
Purity
≥98% (HPLC)
Packaging
10MG
Price
$70.5
Updated
2023/06/20
Sigma-Aldrich
Product number
SML1371
Product name
Prucalopride
Purity
≥98% (HPLC)
Packaging
50MG
Price
$273
Updated
2023/06/20
Cayman Chemical
Product number
24192
Product name
Prucalopride
Purity
≥98%
Packaging
10mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
24192
Product name
Prucalopride
Purity
≥98%
Packaging
50mg
Price
$193
Updated
2024/03/01
Cayman Chemical
Product number
24192
Product name
Prucalopride
Purity
≥98%
Packaging
100mg
Price
$330
Updated
2024/03/01
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Prucalopride Chemical Properties,Usage,Production

Description

Prucalopride is a potent and selective agonist of the serotonin (5-HT) receptor subtype 5-HT4 (Kis = 2.5 and 8 nM for human 5-HT4A and 5-HT4B, respectively). Prucalopride is greater than 250-fold selective for 5-HT4 over a panel of 53 overexpressed receptors, including 5-HT subtypes, but does bind to human dopamine D4 and sigma-1 (σ1) receptors and mouse 5-HT3 receptors (Kis = 2.3, 3.7, and 3.8 μM, respectively). It induces contractions in guinea pig colon with an EC50 value of 33 nM, an effect that is blocked by the 5-HT4 antagonist GR113808 but not the 5-HT2A and 5-HT3 antagonists ketanserin and granisetron , respectively. It also facilitates non-cholinergic contractions induced by electrical stimulation. In fasted dogs, oral administration of prucalopride increases colonic motility by inhibiting distal colon contractions (ED50 = 0.04 mg/kg), an effect that is blocked by pretreatment with the 5-HT4 antagonist GR125487. Prucalopride (5-10 mg/kg, s.c.) increases acetylcholine and histamine levels in the rat prefrontal cortex by 2.4-fold and 3-fold, respectively, and increases the power of hippocampal theta oscillations. Formulations containing prucalopride have been used in the treatment of chronic idiopathic constipation.

Definition

ChEBI: Prucalopride is a member of benzamides.

Biochem/physiol Actions

In healthy male individuals, prucalopride decreases the display of esophageal acid and promotes gastric emptying. It is effective, safe and shows good tolerance for the treatment of men with chronic constipation.

Enzyme inhibitor

This novel enterokinetic drug (FW = 367.87 g/mol; CAS 179474-81-8), also known by the tradename Resolor? and its systematic name, 4-amino-5- chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7- carboxamide, is a selective, high affinity serotonin 5-HT4 receptor agonist with that stimulates colonic mass movements, which provide the main propulsive force for defecation. It exhibits high affinity to both 5-HT4 receptor isoforms, with respective pKi values of 8.60 and 8.10 for the human 5-HT4A and 5-HT4B receptors. Based on 50 other binding assays,tonly the human D4 receptor (pKi = 5.63), the mouse 5-HT3 receptor (pKi = 5.41) and the human s1 (pKi = 5.43) shown measurable affinity, resulting in >290x selectivity for 5-HT4 receptors. Prucalopride also differs from other 5-HT4 agonists, such as tegaserod and cisapride, that interact with other receptors (5-HT1B/D and cardiac human ether-a-go-go K+ or hERG channel, respectively).

Prucalopride Preparation Products And Raw materials

Raw materials

Preparation Products

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Prucalopride Suppliers

China 192 India 5 Japan 1 The Netherlands 1 United Kingdom 2 United States 12 USA 1 Global 214
Shanghai Famo Bio-chemical Technology Company Ltd.
Tel
+862136680027 15800370750
Email
sales@famobiotech.com
Country
China
ProdList
509
Advantage
56
Nanjing Shizhou Biotechnology Co., Ltd
Tel
025-85563444 15850508050
Fax
18013869214
Email
rose.shi@synzest.com
Country
China
ProdList
292
Advantage
58
ZHIWE CHEMTECH CO LTD
Tel
021-20221225 13917446399
Fax
QQ:115820162
Email
sales@zhiwe.net
Country
China
ProdList
588
Advantage
61
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6011
Advantage
61
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
zhangsn@titansci.com
Country
China
ProdList
14113
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
Advantage
64
Jiangsu Vcare PharmaTech Co., Ltd.
Tel
025-58741518; 18013018875
Fax
+86-25-58744115
Email
sales@vcarepharmatech.com
Country
China
ProdList
308
Advantage
61
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5700
Advantage
66
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4647
Advantage
58
Shanghai SynFarm Pharmaceutical Technology Co., Ltd.
Tel
021-50793966 18917198199
Fax
+86-21-50793967
Email
info@synfarm.com
Country
China
ProdList
280
Advantage
58
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View Lastest Price from Prucalopride manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
Product
Prucalopride 179474-81-8
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-09-04
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Prucalopride 179474-81-8
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
100kg
Release date
2021-10-22
Zhuozhou Wenxi import and Export Co., Ltd
Product
Prucalopride 179474-81-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

179474-81-8, PrucaloprideRelated Search:

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  • Prucalopride
  • 4-Amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide
  • 4-Amino-5-chloro-2,3-dihydro-N-(1-(3-methoxypropyl)-4-piperidyl)-7-benzofurancarboxamide
  • R 093877
  • R093877
  • 4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide
  • CS-219
  • Resolor
  • Unii-0A09iuw5tp
  • Prucalopride(R-93877)
  • 7-BenzofurancarboxaMide, 4-aMino-5-chloro-2,3-dihydro-N-[1-(3-Methoxypropyl)-4-piperidinyl]-
  • 4-Amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide
  • Prucalopride, >=98%
  • Prucalopride, 99%, a 5-HT Receptor agonist
  • Prucalopride USP/EP/BP
  • Prucalopride (R-108512, R-93877)
  • Prucalopride 13CD3Q: What is Prucalopride 13CD3 Q: What is the CAS Number of Prucalopride 13CD3 Q: What is the storage condition of Prucalopride 13CD3 Q: What are the applications of Prucalopride 13CD3
  • PrucaloprideQ: What is Prucalopride Q: What is the CAS Number of Prucalopride Q: What is the storage condition of Prucalopride Q: What are the applications of Prucalopride
  • 4-Amino-5-chloro-N-[1-(3-methoxypropyl)-4-piperidyl]-2,3-dihydrobenzofuran-7-carboxamide
  • 179474-81-8
  • Inhibitors
  • API