ChemicalBook > CAS DataBase List > NCT-501
NCT-501
- Product Name
- NCT-501
- CAS No.
- 1802088-50-1
- Chemical Name
- NCT-501
- Synonyms
- CS-2069;NCT-501;NCT-501 >=98% (HPLC);Inhibitor,Aldehyde Dehydrogenase (ALDH),inhibit,NCT-501,NCT 501;8-((4-(cyclopropanecarbonyl)piperazin-1-yl)methyl)-7-isopentyl-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione;1H-Purine-2,6-dione, 8-[[4-(cyclopropylcarbonyl)-1-piperazinyl]methyl]-3,7-dihydro-1,3-dimethyl-7-(3-methylbutyl)-
- CBNumber
- CB73043300
- Molecular Formula
- C21H32N6O3
- Formula Weight
- 416.52
- MOL File
- 1802088-50-1.mol
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NCT-501 Property
- Boiling point:
- 627.3±65.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥20.85 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥11 mg/mL in EtOH
- form
- solid
- pka
- 5.26±0.10(Predicted)
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 21162
- Product name
- NCT-501
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21162
- Product name
- NCT-501
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $233
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21162
- Product name
- NCT-501
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $412
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21162
- Product name
- NCT-501
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $887
- Updated
- 2024/03/01
AK Scientific
- Product number
- 4502EC
- Product name
- 8-[[4-(Cyclopropanecarbonyl)piperazin-1-yl]methyl]-1,3-dimethyl-7-(3-methylbutyl)purine-2,6-dione
- Packaging
- 25mg
- Price
- $1086
- Updated
- 2021/12/16
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NCT-501 Chemical Properties,Usage,Production
Description
NCT-501 is a potent, reversible, theophylline-based inhibitor of ALDH1A1 (IC50 = 40 nM for the human form). It is selective for ALDH1A1 over other ALDH isozymes as well as other dehydrogenases. Pharmacokinetic studies indicate that NCT-501 has high bioavailability when delivered intraperitoneally, with rapid phase I modification in the liver.
References
yang s m, yasgar a, miller b, et al. discovery of nct-501, a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1a1 (aldh1a1)[j]. journal of medicinal chemistry, 2015, 58(15): 5967-5978.
NCT-501 Preparation Products And Raw materials
Raw materials
Preparation Products
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