NCT-501

Product Name: NCT-501
CAS No.: 1802088-50-1
Chemical Name: NCT-501
Synonyms: CS-2069;NCT-501;NCT-501 >=98% (HPLC);NCT-501, 10 mM in DMSO;Inhibitor,Aldehyde Dehydrogenase (ALDH),inhibit,NCT-501,NCT 501;8-((4-(cyclopropanecarbonyl)piperazin-1-yl)methyl)-7-isopentyl-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione;8-((4-(cyclopropanecarbonyl)piperazin-1-yl)methyl)-7-isopentyl-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione , NCT-501;1H-Purine-2,6-dione, 8-[[4-(cyclopropylcarbonyl)-1-piperazinyl]methyl]-3,7-dihydro-1,3-dimethyl-7-(3-methylbutyl)-
CBNumber: CB73043300
Molecular Formula: C21H32N6O3
Formula Weight: 416.52
MOL File: 1802088-50-1.mol

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NCT-501 Property

Boiling point:: 627.3±65.0 °C(Predicted)
Density: 1.37±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥20.85 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥11 mg/mL in EtOH
form: solid
pka: 5.26±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21162
Product name: NCT-501
Purity: ≥98%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 21162
Product name: NCT-501
Purity: ≥98%
Packaging: 5mg
Price: $233
Updated: 2024/03/01

Cayman Chemical

Product number: 21162
Product name: NCT-501
Purity: ≥98%
Packaging: 10mg
Price: $412
Updated: 2024/03/01

Cayman Chemical

Product number: 21162
Product name: NCT-501
Purity: ≥98%
Packaging: 25mg
Price: $887
Updated: 2024/03/01

AK Scientific

Product number: 4502EC
Product name: 8-[[4-(Cyclopropanecarbonyl)piperazin-1-yl]methyl]-1,3-dimethyl-7-(3-methylbutyl)purine-2,6-dione
Packaging: 25mg
Price: $1086
Updated: 2021/12/16

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NCT-501 Chemical Properties,Usage,Production

Description

NCT-501 is a potent, reversible, theophylline-based inhibitor of ALDH1A1 (IC₅₀ = 40 nM for the human form). It is selective for ALDH1A1 over other ALDH isozymes as well as other dehydrogenases. Pharmacokinetic studies indicate that NCT-501 has high bioavailability when delivered intraperitoneally, with rapid phase I modification in the liver.

Uses

NCT-501 is a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), inhibits hALDH1A1 with IC50 of 40 nM, typically shows better selectivity over other ALDH isozymes and other dehydrogenases (hALDH1B1, hALDH3A1, and hALDH2, IC50 >57 μM).

in vivo

NCT-501 (100 μg/animal; i.t.; every alternate day for 20 days) shows a 78% inhibition in tumor growth in Cal-27 CisR derived xenografts^[1].

Animal Model:	5-6 weeks old male Hsd: Athymic Nude-Foxn1nu (immuno-deficient-mice bearing Cal-27 CisR cells)^[1]
Dosage:	100μg/animal
Administration:	Intra-tumorally (i.t); every alternate day for 20 days
Result:	Showed a 78% inhibition in tumor growth in Cal-27 CisR derived xenografts.

IC 50

ALDH1

References

yang s m, yasgar a, miller b, et al. discovery of nct-501, a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1a1 (aldh1a1)[j]. journal of medicinal chemistry, 2015, 58(15): 5967-5978.

NCT-501 Preparation Products And Raw materials

Raw materials

Preparation Products

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NCT-501 Suppliers

China 88 United States 11 Global 99

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
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MedChemexpress LLC

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Shanghai Lollane Biological Technology Co.,Ltd.

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Guangzhou QiYun Biotechnology Co., Ltd.

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Shanghai YuanYe Biotechnology Co., Ltd.

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Tianjin Kailiqi Biotechnology Co., Ltd.

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Shanghai SuperLan Chemcial Technique Centre

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Beijing Solarbio Science & Tecnology Co., Ltd.

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1802088-50-1, NCT-501Related Search:

NCT-501

CS-2069

1H-Purine-2,6-dione, 8-[[4-(cyclopropylcarbonyl)-1-piperazinyl]methyl]-3,7-dihydro-1,3-dimethyl-7-(3-methylbutyl)-

NCT-501 >=98% (HPLC)

Inhibitor,Aldehyde Dehydrogenase (ALDH),inhibit,NCT-501,NCT 501

8-((4-(cyclopropanecarbonyl)piperazin-1-yl)methyl)-7-isopentyl-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione

8-((4-(cyclopropanecarbonyl)piperazin-1-yl)methyl)-7-isopentyl-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione , NCT-501

NCT-501, 10 mM in DMSO

1802088-50-1