ChemicalBook > CAS DataBase List > NCT-501
NCT-501
- Product Name
- NCT-501
- CAS No.
- 1802088-50-1
- Chemical Name
- NCT-501
- Synonyms
- CS-2069;NCT-501;NCT-501 >=98% (HPLC);Inhibitor,Aldehyde Dehydrogenase (ALDH),inhibit,NCT-501,NCT 501;8-((4-(cyclopropanecarbonyl)piperazin-1-yl)methyl)-7-isopentyl-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione;8-((4-(cyclopropanecarbonyl)piperazin-1-yl)methyl)-7-isopentyl-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione , NCT-501;1H-Purine-2,6-dione, 8-[[4-(cyclopropylcarbonyl)-1-piperazinyl]methyl]-3,7-dihydro-1,3-dimethyl-7-(3-methylbutyl)-
- CBNumber
- CB73043300
- Molecular Formula
- C21H32N6O3
- Formula Weight
- 416.52
- MOL File
- 1802088-50-1.mol
More
Less
NCT-501 Property
- Boiling point:
- 627.3±65.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥20.85 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥11 mg/mL in EtOH
- form
- solid
- pka
- 5.26±0.10(Predicted)
- color
- White to off-white
More
Less
N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 21162
- Product name
- NCT-501
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21162
- Product name
- NCT-501
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $233
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21162
- Product name
- NCT-501
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $412
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21162
- Product name
- NCT-501
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $887
- Updated
- 2024/03/01
AK Scientific
- Product number
- 4502EC
- Product name
- 8-[[4-(Cyclopropanecarbonyl)piperazin-1-yl]methyl]-1,3-dimethyl-7-(3-methylbutyl)purine-2,6-dione
- Packaging
- 25mg
- Price
- $1086
- Updated
- 2021/12/16
More
Less
NCT-501 Chemical Properties,Usage,Production
Description
NCT-501 is a potent, reversible, theophylline-based inhibitor of ALDH1A1 (IC50 = 40 nM for the human form). It is selective for ALDH1A1 over other ALDH isozymes as well as other dehydrogenases. Pharmacokinetic studies indicate that NCT-501 has high bioavailability when delivered intraperitoneally, with rapid phase I modification in the liver.
References
yang s m, yasgar a, miller b, et al. discovery of nct-501, a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1a1 (aldh1a1)[j]. journal of medicinal chemistry, 2015, 58(15): 5967-5978.
NCT-501 Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
NCT-501 Suppliers
- Tel
- 0411-62910999 13889544652
- meilunui@163.com
- Country
- China
- ProdList
- 4727
- Advantage
- 58
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- 021-58955995
- Fax
- 609-228-5909
- sales@medchemexpress.cn
- Country
- United States
- ProdList
- 4861
- Advantage
- 58
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4566
- Advantage
- 55
- Tel
- 021-13816613772 13816613772
- Fax
- QQ: 12922499
- huahero21@sina.com
- Country
- China
- ProdList
- 533
- Advantage
- 55
- Tel
- 020-61288194 61288195
- Fax
- 020-61288700
- 505721671@qq.com
- Country
- China
- ProdList
- 3866
- Advantage
- 58
- Tel
- 15076683720
- Fax
- 022-23754520
- klq@cw-bio.com
- Country
- China
- ProdList
- 4966
- Advantage
- 55
- Tel
- 021-2022843681 15618226720
- Fax
- +86-21-51601218
- lucy@atkchemical.com
- Country
- China
- ProdList
- 9952
- Advantage
- 58
- Tel
- 010-50973130 4009686088
- 3193328036@qq.com
- Country
- China
- ProdList
- 29785
- Advantage
- 68
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58