RESINIFERATOXIN
- Product Name
- RESINIFERATOXIN
- CAS No.
- 57444-62-9
- Chemical Name
- RESINIFERATOXIN
- Synonyms
- RTX;RESINIFERATOXIN;Resiniferatoxin >99%;Resiniferatoxin (80%);Resiniferatoxin, 98.5%;RESINIFERATOXIN,HIGHPURITY;DSDNAKHZNJAGHN-IHCAYWNCSA-N;RESINIFERATOXIN, 99%, HIGH PURITY;RESINIFERATOXIN,EUPHORBIA POISONII;RESINIFERATOXIN AUS EUPHORBIA POISONII
- CBNumber
- CB7304594
- Molecular Formula
- C37H40O9
- Formula Weight
- 628.71
- MOL File
- 57444-62-9.mol
RESINIFERATOXIN Property
- Boiling point:
- 768.7±60.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO to 100mM and to 50mM in ethanol
- form
- Solid
- pka
- 9.85±0.20(Predicted)
- color
- White to off-white
- BRN
- 5371150
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Safety
- Hazard Codes
- T
- Risk Statements
- 25-35
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 2928 6.1/PG 2
- WGK Germany
- 3
- RTECS
- CY1633700
- F
- 10-23
- HazardClass
- 6.1(a)
- PackingGroup
- II
- HS Code
- 29329990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H314Causes severe skin burns and eye damage
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- J62458
- Product name
- Resiniferatoxin, 99+%
- Packaging
- 1mg
- Price
- $374
- Updated
- 2021/12/16
- Product number
- 11349
- Product name
- Resiniferatoxin
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $156
- Updated
- 2021/12/16
- Product number
- AG-CN2-0534-MC01
- Product name
- Resiniferatoxin
- Purity
- ≥98%(HPLC)
- Packaging
- 0.1mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- FR45558
- Product name
- Resiniferatoxin
- Packaging
- 1mg
- Price
- $650
- Updated
- 2021/12/16
- Product number
- TOX0000335
- Product name
- RESINIFERATOXIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $698.65
- Updated
- 2021/12/16
RESINIFERATOXIN Chemical Properties,Usage,Production
Description
Resiniferatoxin (57444-62-9) is an ultrapotent TRPV1 activator (Ki=43 pM).1 Resiniferatoxin is 100-10,000 fold more potent than capsaicin for most responses yet displays a spectrum of activity distinct from capsaicin.2 A potent sensory neuron excitotoxin.3 Induces a long lasting analgesia in a rodent model of burn pain.4 SEVERE IRRITANT – HANDLE WITH CARE
Chemical Properties
white to off-white solid
Uses
Resiniferatoxin has been used as an agonist to transient receptor potential vanilloid 2 (TRPV2):
- for complex preparation for cryo-electron microscopy structural studies
- to test its effect towards immune responses to?P.?aeruginosa in sensory neurons associated with the cornea
- to study its effects in the denervation of the peripheral sensory nerves in psoriatic mice
Definition
ChEBI: Resiniferatoxin is a heteropentacyclic compound found in Euphorbia poissonii with molecular formula C37H40O9. It is an agonist of the transient receptor potential cation channel subfamily V member 1 (TrpV1). It has a role as a TRPV1 agonist, a plant metabolite, a neurotoxin and an analgesic. It is a diterpenoid, an ortho ester, a tertiary alpha-hydroxy ketone, a member of phenols, a monomethoxybenzene, an organic heteropentacyclic compound, a carboxylic ester and an enone.
Hazard
A poison.
Biological Activity
Ultrapotent analog of capsaicin that is an agonist at vanilloid receptors (K i = 43 pM). Like capsaicin, it acts as a selective modulator of primary afferent neurons. Also available as part of the Vanilloid TRPV1 Receptor Tocriset™ .
Biochem/physiol Actions
Resiniferatoxin (RTX) is an analog of capsaicin. It effectively ablates corneal sensory neurons by activating transient receptor potential vanilloid 1 (TRPV1) channels. RTX facilitates corneal bacterial clearance. It also elicits protective functionality towards cardiac function in a rat model with congestive heart failure (CHF).
References
1) Szolcsanyi et al. (1990), Resiniferatoxin: an ultrapotent selective modulator of capsaicin-sensitive primary afferent neurons; J. Pharmacol. Exp. Ther., 255 923 2) Szallasi and Blumberg (1998), Resiniferatoxin and its analogs provide novel insights into the pharmacology of the vanilloid (capsaicin) receptor; Life Sci. 47 1399 3) Winter et al. (1990) Cellular mechanism of action of resiniferatoxin: a potent sensory neuron excitotoxin; Brain Res. 520 131 4) Salas et al. (2017) Local Resiniferatoxin Induces Long-Lasting Analgesia in a Rat Model of Full Thickness Thermal Injury; Pain Med. 18 2453
RESINIFERATOXIN Preparation Products And Raw materials
Raw materials
Preparation Products
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