IMETIT DIHYDROBROMIDE Property

storage temp. 

Store at RT

solubility 

H₂O: soluble

form 

solid

color 

off-white

Water Solubility 

Freely soluble in water, practically insoluble in acetone /n

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

IMETIT DIHYDROBROMIDE Chemical Properties,Usage,Production

Description

Imetit is a histamine H₃ and H₄ receptor agonist (K_is = 0.3 and 2.7 nM, respectively, in radioligand binding assays). It is selective for histamine H₃ and H₄ receptors over H₁ and H₂ receptors at concentrations up to 100 μM, as well as the serotonin (5-HT) receptor subtype 5-HT₃ (K_i = 240 nM)., Imetit reduces potassium-induced increases in histamine levels in isolated rat cerebral cortex slices (EC₅₀ = 2.8 nM). It increases scratching in mice (ED₅₀ = 0.9 μmol), an effect that is reduced by the H₃ receptor antagonist thioperamide .

Uses

Imetit dihydrobromide is a high affinity agonist at the histamine H3- and H4-receptors.

Definition

ChEBI: A hydrobromide salt obtained by reaction of imetit with two equivalents of hydrobromic acid. An extremely potent, high affinity agonist at H3 and H4 receptors (Ki values are 0.3 and 2.7 nM respectively). Induces sh pe change in eosinophils with an EC50 of 25 nM. Centrally active following systemic administration.

Biological Activity

An extremely potent, high affinity agonist at H 3 and H 4 receptors (K i values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC 50 of 25 nM. Centrally active following systemic administration. Also available as part of the Histamine H 3 Receptor Tocriset™ .

Biochem/physiol Actions

Potent and selective H3 histamine receptor agonist.

storage

Store at RT