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IMETIT DIHYDROBROMIDE

Product Name
IMETIT DIHYDROBROMIDE
CAS No.
32385-58-3
Chemical Name
IMETIT DIHYDROBROMIDE
Synonyms
Imetit hydrobromide;Imetit dihydrobromid;IMETIT DIHYDROBROMIDE;VUF 8325 dihydrobromide;SKF 91105 dihydrobromide;S-[2-(Imidazol-4-yl)ethyl]isothiourea2HBr;IMETIT DIHYDROBROMIDE POTENT AND SELECTI VE;5-[2-(IMIDAZOL-4-YL)ETHYL]ISOTHIOUREA DIHYDROBROMIDE;S-[2-(IMIDAZOL-4-YL)ETHYL]ISOTHIOUREA DIHYDROBROMIDE;S-[2-(4(5)-Imidazolyl)ethyl]isothiourea dihydrobromide
CBNumber
CB7305203
Molecular Formula
C6H12Br2N4S
Formula Weight
332.06
MOL File
32385-58-3.mol
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IMETIT DIHYDROBROMIDE Property

storage temp. 
Store at RT
solubility 
H2O: soluble
form 
solid
color 
off-white
Water Solubility 
Freely soluble in water, practically insoluble in acetone /n
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I135
Product name
Imetit dihydrobromide
Purity
≥98% (HPLC)
Packaging
10mg
Price
$162
Updated
2024/03/01
Sigma-Aldrich
Product number
I135
Product name
Imetit dihydrobromide
Purity
≥98% (HPLC)
Packaging
25mg
Price
$293
Updated
2024/03/01
Alfa Aesar
Product number
J62346
Product name
Imetit dihydrobromide, 98%
Packaging
50mg
Price
$375.65
Updated
2024/03/01
Alfa Aesar
Product number
J62346
Product name
Imetit dihydrobromide, 98%
Packaging
25mg
Price
$173
Updated
2021/12/16
Cayman Chemical
Product number
29517
Product name
Imetit (hydrobromide)
Packaging
5mg
Price
$73
Updated
2024/03/01
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IMETIT DIHYDROBROMIDE Chemical Properties,Usage,Production

Description

Imetit is a histamine H3 and H4 receptor agonist (Kis = 0.3 and 2.7 nM, respectively, in radioligand binding assays). It is selective for histamine H3 and H4 receptors over H1 and H2 receptors at concentrations up to 100 μM, as well as the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 240 nM)., Imetit reduces potassium-induced increases in histamine levels in isolated rat cerebral cortex slices (EC50 = 2.8 nM). It increases scratching in mice (ED50 = 0.9 μmol), an effect that is reduced by the H3 receptor antagonist thioperamide .

Uses

Imetit dihydrobromide is a high affinity agonist at the histamine H3- and H4-receptors.

Definition

ChEBI: A hydrobromide salt obtained by reaction of imetit with two equivalents of hydrobromic acid. An extremely potent, high affinity agonist at H3 and H4 receptors (Ki values are 0.3 and 2.7 nM respectively). Induces sh pe change in eosinophils with an EC50 of 25 nM. Centrally active following systemic administration.

Biological Activity

An extremely potent, high affinity agonist at H 3 and H 4 receptors (K i values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC 50 of 25 nM. Centrally active following systemic administration. Also available as part of the Histamine H 3 Receptor Tocriset™ .

Biochem/physiol Actions

Potent and selective H3 histamine receptor agonist.

storage

Store at RT

IMETIT DIHYDROBROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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IMETIT DIHYDROBROMIDE Suppliers

China 23 Germany 1 Japan 1 Switzerland 1 The Netherlands 1 United Kingdom 5 United States 11 Global 43
BOC Sciences
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1-631-485-4226; 16314854226
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info@bocsci.com
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United States
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EMMX Biotechnology LLC
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888-539-0666
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888-539-0666
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info@emmx.com
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TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
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Aladdin Scientific
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+1-+1(833)-552-7181
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sales@aladdinsci.com
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ApexBio Technology
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Cayman Chemical Company
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cayman@caymanchem.com
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United States
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United States Biological
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chemicals@usbio.net
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MedChemExpress
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Riedel-de Haen AG
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Santa Cruz Biotechnology, Inc.
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MP Biomedicals, Inc.
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32385-58-3, IMETIT DIHYDROBROMIDERelated Search:

Angeli’s Salt Lignosulfonic acid 1-Vinylimidazole IMETIT DIHYDROBROMIDE

  • S-[2-(IMIDAZOL-4-YL)ETHYL]ISOTHIOUREA DIHYDROBROMIDE
  • 5-[2-(IMIDAZOL-4-YL)ETHYL]ISOTHIOUREA DIHYDROBROMIDE
  • IMETIT DIHYDROBROMIDE
  • IMETIT DIHYDROBROMIDE POTENT AND SELECTI VE
  • S-[2-(Imidazol-4-yl)ethyl]isothiourea2HBr
  • CarbaMiMidothioic acid, 2-(1H-iMidazol-4-yl)ethyl ester, dihydrobroMide
  • S-[2-(4(5)-Imidazolyl)ethyl]isothiourea dihydrobromide
  • SKF 91105 dihydrobromide
  • VUF 8325 dihydrobromide
  • Imetit dihydrobromid
  • Imetit hydrobromide
  • Carbamimidothioic acid, 2-(1H-imidazol-5-yl)ethyl ester, dihydrobromide
  • 32385-58-3
  • C6H10N4S2HBr