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Voxelotor

Product Name
Voxelotor
CAS No.
1446321-46-5
Chemical Name
Voxelotor
Synonyms
GBT 440;GTx011;Hemoglobin Modulators-1;2-Hydroxy-6-{[2-(1-isopropyl-1H-pyrazol-5-yl)-3-pyridinyl]methoxy}benzaldehyde;2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde;Oxbryta);Voxelotor;2H7]-Voxelotor;GBT-440(Voxelotor);Voxelotor (GBT-440
CBNumber
CB73053893
Molecular Formula
C19H19N3O3
Formula Weight
337.37
MOL File
1446321-46-5.mol
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Voxelotor Property

Melting point:
95 - 97oC
Boiling point:
539.2±50.0 °C(Predicted)
Density 
1.23±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer, Under inert atmosphere
solubility 
Chloroform (Slightly), DMSO (Slightly)
pka
7.67±0.10(Predicted)
form 
Solid
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23933
Product name
GBT-440
Purity
≥98%
Packaging
1mg
Price
$25
Updated
2024/03/01
Cayman Chemical
Product number
23933
Product name
GBT-440
Purity
≥98%
Packaging
5mg
Price
$75
Updated
2024/03/01
Cayman Chemical
Product number
23933
Product name
GBT-440
Purity
≥98%
Packaging
10mg
Price
$125
Updated
2024/03/01
Cayman Chemical
Product number
23933
Product name
GBT-440
Purity
≥98%
Packaging
25mg
Price
$219
Updated
2024/03/01
TRC
Product number
G268015
Product name
GBT440
Packaging
5mg
Price
$400
Updated
2021/12/16
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Voxelotor Chemical Properties,Usage,Production

Uses

GBT 440 is a potent allosteric effector of sickle cell hemoglobin (Hb) that increases the affinity of Hb for oxygen and inhibits its polymerization when subjected to hypoxic conditions.

in vivo

Voxelotor (GBT440；100-150 mg/kg；通过口服强饲法每天给药两次，持续 9-12 天) 在镰状细胞病 (SCD) 小鼠模型中减少离体镰状细胞并延长红细胞 (RBC) 的半衰期[1]。
Voxelotor 显示小鼠的 T1/2 为 11.7、19.1±1.5、66.0±11、28.8±4.0 小时 (70 mg/kg；iv)，大鼠 (1.6 mg/kg；iv)，狗 (1 mg/kg；iv)，和 momkey (1 mg/kg；iv)，分别[1]。
Voxelotor 对小鼠 (30 mg/kg；po)、大鼠 (7.2 mg/kg；po)、狗 (2.5 mg/kg；po) 和 momkey (4.25 mg/kg；po) Cmaxs 为 81.9, 71.2±6.0, 5.56±1.6, and 25.2±5.5 μg/mL[1]。

Animal Model:HbSS Townes knock-in sickle mice (SS mice)[1]
Dosage:100 and 150 mg/kg
Administration:Oral administration; twice a day; for 9-12 days
Result:Reduced haemolysis.
Animal Model:C57BL/6J mice, Sprague-Dawley rats, Beagle dogs and Cynomolgus monkeys[1]
Dosage:70, 1.6, 1 and 1 mg/kg for mice, rats, dogs and monkeys, respectively
30, 7.2, 2.5 and 4.25 mg/kg for mice, rats, dogs and monkeys, respectively
Administration:Intravenous (IV: 70, 1 6, 1 and 1 mg/kg, respectively)
Oral (PO: 30, 7 2, 2 5 and 4 3 mg/kg, respectively)
Result:T1/2s of 11.7, 19.1±1.5, 66.0±11, 28.8±4.0 hours for mouse (70 mg/kg; i.v.), rat (1.6 mg/kg; i.v.), dog (1 mg/kg; i.v.), and momkey (1 mg/kg; i.v.), respectively.
Cmaxs of 81.9, 71.2±6.0, 5.56±1.6, and 25.2±5.5 μg/mL for mouse (30 mg/kg; p.o.), rat (7.2 mg/kg; p.o.), dog (2.5 mg/kg; p.o.), and momkey (4.25 mg/kg; p.o.), respectively.

Voxelotor Preparation Products And Raw materials

Raw materials

Preparation Products

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Voxelotor Suppliers

China 112 India 2 United States 11 Global 125
Chengdu Celes Technology Co., Ltd
Tel
19982073091
Email
2538834896@qq.com
Country
China
ProdList
76
Advantage
58
Deyang Sino Biotech. Co., LTD
Tel
+86-19182167371 +86-19182167371
Email
service@synlord.com
Country
China
ProdList
105
Advantage
58
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 17702719238
Email
sales@sun-shinechem.com
Country
China
ProdList
1015
Advantage
64
Chengdu HappySyn Pharmaceutical Technology Co., Ltd.
Tel
028-85114309 18982182443
Email
yangli@happysyn.com
Country
China
ProdList
2039
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Hangzhou Cheminspire Technology Co., Ltd.
Tel
0571-89081561; 10006559855
Fax
0571 89081561
Email
info@cheminspire.com
Country
China
ProdList
412
Advantage
58
Shanghaizehan biopharma technology co., Ltd.
Tel
021-61350663 13052117465
Fax
021-61350662
Email
sales@zehanbiopharma.com
Country
China
ProdList
996
Advantage
55
Suzhou PengXu PharmaTech Co., Ltd.
Tel
15850786624
Email
sales@cqpharm.com
Country
China
ProdList
88
Advantage
58
Tcichem, Inc.
Tel
13918644899
Fax
-
Email
tianchong009@hotmail.com
Country
China
ProdList
1787
Advantage
55
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View Lastest Price from Voxelotor manufacturers

Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
Voxelotor 1446321-46-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2024-04-01
Henan Fengda Chemical Co., Ltd
Product
Voxelotor 1446321-46-5
Price
US $35.00-1.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-28
Career Henan Chemical Co
Product
Voxelotor 1446321-46-5
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-08

1446321-46-5, VoxelotorRelated Search:


  • 2-hydroxy-6-([2-[1-(propan-2-yl)-1H-pyrazol-5-yl]pyridin-3-yl]methoxy)benzaldehyde
  • GBT 440
  • 2-Hydroxy-6-{[2-(1-isopropyl-1H-pyrazol-5-yl)-3-pyridinyl]methoxy}benzaldehyde
  • Hemoglobin Modulators-1
  • 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
  • Voxelotor(GBT440, GTX011)
  • Voxelotor
  • Voxelotor, GBT-440, GBT 440, GBT440, GTx-011, GTx011, GTx 011
  • VOXELOTOR, GBT-440, GBT 440, GBT440, GTX-011, GTX011, GTX 011;
  • GTx011
  • GTX011;GTX011;GTX011
  • GBT-440(Voxelotor)
  • Benzaldehyde, 2-hydroxy-6-[[2-[1-(1-methylethyl)-1H-pyrazol-5-yl]-3-pyridinyl]methoxy]-
  • Oxbryta)
  • Voxelotor (GBT-440
  • Voxelotor,GBT440,GTX011,Hemoglobin Modulators-1
  • 2H7]-Voxelotor
  • 2-Hydroxy-6-[[2-[1-(1-methylethyl)-1H-pyrazol-5-yl]-3-pyridinyl]methoxy]benzaldehyde
  • Lanreotide Impurity 33
  • 2-Hydroxy-6-[[2-(1-isopropyl-5-pyrazoyl)-3-pyridyl]methoxy]benzaldehyde
  • 1446321-46-5
  • API