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Voxelotor

Product Name
Voxelotor
CAS No.
1446321-46-5
Chemical Name
Voxelotor
Synonyms
GBT 440;GTx011;Hemoglobin Modulators-1;2-Hydroxy-6-{[2-(1-isopropyl-1H-pyrazol-5-yl)-3-pyridinyl]methoxy}benzaldehyde;2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde;Oxbryta);Voxelotor;2H7]-Voxelotor;GBT-440(Voxelotor);Voxelotor (GBT-440
CBNumber
CB73053893
Molecular Formula
C19H19N3O3
Formula Weight
337.37
MOL File
1446321-46-5.mol
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Voxelotor Property

Melting point:
95 - 97oC
Boiling point:
539.2±50.0 °C(Predicted)
Density 
1.23±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer, Under inert atmosphere
solubility 
Chloroform (Slightly), DMSO (Slightly)
form 
Solid
pka
7.67±0.10(Predicted)
color 
White to Off-White
InChI
InChI=1S/C19H19N3O3/c1-13(2)22-16(8-10-21-22)19-14(5-4-9-20-19)12-25-18-7-3-6-17(24)15(18)11-23/h3-11,13,24H,12H2,1-2H3
InChIKey
FWCVZAQENIZVMY-UHFFFAOYSA-N
SMILES
C(=O)C1=C(OCC2=CC=CN=C2C2N(C(C)C)N=CC=2)C=CC=C1O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23933
Product name
GBT-440
Purity
≥98%
Packaging
1mg
Price
$28
Updated
2026/04/30
Cayman Chemical
Product number
23933
Product name
GBT-440
Purity
≥98%
Packaging
5mg
Price
$83
Updated
2026/04/30
Cayman Chemical
Product number
23933
Product name
GBT-440
Purity
≥98%
Packaging
10mg
Price
$138
Updated
2026/04/30
Cayman Chemical
Product number
23933
Product name
GBT-440
Purity
≥98%
Packaging
25mg
Price
$241
Updated
2026/04/30
Cayman Chemical
Product number
23933
Product name
GBT-440
Purity
≥98%
Packaging
1mg
Price
$25
Updated
2024/03/01
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Voxelotor Chemical Properties,Usage,Production

Uses

GBT 440 is a potent allosteric effector of sickle cell hemoglobin (Hb) that increases the affinity of Hb for oxygen and inhibits its polymerization when subjected to hypoxic conditions.

Biological Activity

Voxelotor improves the abnormal aggregation of hemoglobin under hypoxic conditions, which is the main cause of sickle cell disease-related red blood cell dysfunction, by forming a Schiff base with the N-terminal valine of the hemoglobin alpha chain, increasing the affinity of sickle cell hemoglobin for oxygen and preventing its aggregation.

Synthesis

below shows the synthesis route of  Voxelotor

in vivo

Animal Model:HbSS Townes knock-in sickle mice (SS mice)[1]
Dosage:100 and 150 mg/kg
Administration:Oral administration; twice a day; for 9-12 days
Result:Reduced haemolysis.
Animal Model:C57BL/6J mice, Sprague-Dawley rats, Beagle dogs and Cynomolgus monkeys[1]
Dosage:70, 1.6, 1 and 1 mg/kg for mice, rats, dogs and monkeys, respectively
30, 7.2, 2.5 and 4.25 mg/kg for mice, rats, dogs and monkeys, respectively
Administration:Intravenous (IV: 70, 1 6, 1 and 1 mg/kg, respectively)
Oral (PO: 30, 7 2, 2 5 and 4 3 mg/kg, respectively)
Result:T1/2s of 11.7, 19.1±1.5, 66.0±11, 28.8±4.0 hours for mouse (70 mg/kg; i.v.), rat (1.6 mg/kg; i.v.), dog (1 mg/kg; i.v.), and momkey (1 mg/kg; i.v.), respectively.
Cmaxs of 81.9, 71.2±6.0,  5.56±1.6, and 25.2±5.5 μg/mL for mouse (30 mg/kg; p.o.), rat (7.2 mg/kg; p.o.), dog (2.5 mg/kg; p.o.), and momkey (4.25 mg/kg; p.o.), respectively.

References

[1] Patent: WO2013/102142, 2013, A1. Location in patent: Paragraph 0179
[2] Patent: WO2013/102142, 2013, A1. Location in patent: Paragraph 0178

Voxelotor Preparation Products And Raw materials

Raw materials

Preparation Products

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Voxelotor Suppliers

China 127 India 2 United States 11 Global 140
Chengdu Celes Technology Co., Ltd
Tel
19982073091
Email
2538834896@qq.com
Country
China
ProdList
78
Advantage
58
Deyang Sino Biotech. Co., LTD
Tel
+86-19182167371 +86-19182167371;
Email
service@synlord.com
Country
China
ProdList
110
Advantage
58
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 18971495150;
Email
sales@sun-shinechem.com
Country
China
ProdList
1150
Advantage
64
Chengdu HappySyn Pharmaceutical Technology Co., Ltd.
Tel
028-85114309 18982182443
Email
yangli@happysyn.com
Country
China
ProdList
2236
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
14917
Advantage
59
Hangzhou Cheminspire Technology Co., Ltd.
Tel
0571-89081561; 10006559855
Fax
0571 89081561
Email
info@cheminspire.com
Country
China
ProdList
412
Advantage
58
Shanghaizehan biopharma technology co., Ltd.
Tel
021-61350663 13052117465
Fax
021-61350662
Email
sales@zehanbiopharma.com
Country
China
ProdList
977
Advantage
55
Suzhou PengXu PharmaTech Co., Ltd.
Tel
15850786624
Email
sales@cqpharm.com
Country
China
ProdList
88
Advantage
58
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View Lastest Price from Voxelotor manufacturers

Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
Voxelotor 1446321-46-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2024-04-01
Henan Fengda Chemical Co., Ltd
Product
Voxelotor 1446321-46-5
Price
US $35.00-1.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-28
Career Henan Chemical Co
Product
Voxelotor 1446321-46-5
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-08

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