Azido-PEG3-(CH2)3OH

Azido-PEG3-(CH2)3OH Property

storage temp. 

Storage temp. 2-8°C

solubility 

Soluble in Water, DMSO, DCM, DMF

form 

Liquid

color 

Colorless to light yellow

InChI

InChI=1S/C9H19N3O4/c10-12-11-2-5-15-7-9-16-8-6-14-4-1-3-13/h13H,1-9H2

InChIKey

UUSDGPCVMBHTRJ-UHFFFAOYSA-N

SMILES

C(COCCN=[N+]=[N-])OCCOCCCO

Hazard and Precautionary Statements (GHS)

Azido-PEG3-(CH2)3OH Chemical Properties,Usage,Production

Description

Azido-PEG3-(CH2)3OH is a PEG linker with three carbon chain between PEG fragemnt and OH group, The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

Uses

Azido-PEG3-C3-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-C3-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005