Mal-amido-PEG2-TFP ester

Product Name: Mal-amido-PEG2-TFP ester
CAS No.: 1431291-44-9
Chemical Name: Mal-amido-PEG2-TFP ester
Synonyms: Mal-NH-PEG2-TFP;MAL-dPEG2-TFP ester;MAL-dPEG??-TFP ester;Mal-amido-PEG2-TFP ester;2,3,5,6-Tetrafluorophenyl 3-(2-(2-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)ethoxy)ethoxy)propanoate;Propanoic acid, 3-[2-[2-[[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]ethoxy]ethoxy]-, 2,3,5,6-tetrafluorophenyl ester
CBNumber: CB73062521
Molecular Formula: C20H20F4N2O7
Formula Weight: 476.38
MOL File: 1431291-44-9.mol

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Mal-amido-PEG2-TFP ester Property

storage temp.: Storage temp. -20°C
solubility: Soluble in DMSO, DCM, DMF
form: Solid
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M111058
Product name: Mal-amido-PEG2-TFPester
Packaging: 50mg
Price: $110
Updated: 2021/12/16

BroadPharm

Product number: BP-22739
Product name: Mal-amido-PEG2-TFPester
Purity: 95%
Packaging: 250mg
Price: $180
Updated: 2021/12/16

BroadPharm

Product number: BP-22739
Product name: Mal-amido-PEG2-TFPester
Purity: 95%
Packaging: 1g
Price: $350
Updated: 2021/12/16

dPEG

Product number: 10553
Product name: MAL-dPEG®₁₂-TFPester
Packaging: 1000mg
Price: $750
Updated: 2021/12/16

BroadPharm

Product number: BP-22739
Product name: Mal-amido-PEG2-TFPester
Purity: 95%
Packaging: 5G
Price: $1330
Updated: 2021/12/16

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Mal-amido-PEG2-TFP ester Chemical Properties,Usage,Production

Description

Mal-amido-PEG2-TFP ester is PEG linker containing a maleimide and TFP ester end group. Maleimide groups are reactive with thiols between pH 6.5 and 7.5. The TFP ester can react with primary amine groups and is also less susceptible to undergo hydrolysis compared to NHS ester. The hydrophilic PEG chains increase the water solubility of a compound in aqueous media. Longer PEG chains have improved water solubility relative to shorter PEG chains.

Uses

Mal-amido-PEG2-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005

Mal-amido-PEG2-TFP ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Mal-amido-PEG2-TFP ester manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Mal-amido-PEG2-TFP ester 1431291-44-9
Price: US $0.00/mg
Min. Order: 50mg
Purity: >98.00%
Supply Ability: 50mg
Release date: 2024-05-10

1431291-44-9, Mal-amido-PEG2-TFP esterRelated Search:

Mal-amido-PEG4-TFP ester Mal-amido-PEG12-TFP ester Mal-amido-PEG8-TFP ester

Mal-amido-PEG2-TFP ester

Mal-NH-PEG2-TFP

Propanoic acid, 3-[2-[2-[[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]ethoxy]ethoxy]-, 2,3,5,6-tetrafluorophenyl ester

MAL-dPEG??-TFP ester

MAL-dPEG2-TFP ester

2,3,5,6-Tetrafluorophenyl 3-(2-(2-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)ethoxy)ethoxy)propanoate

1431291-44-9

431291-44-9

C20H20F4N2O7

peg