Methylamino-PEG3-azide
- Product Name
- Methylamino-PEG3-azide
- CAS No.
- 1355197-57-7
- Chemical Name
- Methylamino-PEG3-azide
- Synonyms
- N3-PEG3-NH-Me;N3-PEG3-CH2CH2NHMe;Methylamino-PEG3-N3;Methylamino-PEG3-azide;N3-PEG3-CH2CH2NHMe/Ethanamine, 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-N-methyl-
- CBNumber
- CB73062556
- Molecular Formula
- C9H20N4O3
- Formula Weight
- 232.28
- MOL File
- 1355197-57-7.mol
Methylamino-PEG3-azide Property
- solubility
- Soluble in Water, DMSO, DCM, DMF
N-Bromosuccinimide Price
- Product number
- M563183
- Product name
- Methylamino-PEG3-azide
- Packaging
- 5mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- BP-22907
- Product name
- Methylamino-PEG3-azide
- Purity
- 98%
- Packaging
- 500mg
- Price
- $560
- Updated
- 2021/12/16
- Product number
- BP-22907
- Product name
- Methylamino-PEG3-azide
- Purity
- 98%
- Packaging
- 1g
- Price
- $950
- Updated
- 2021/12/16
Methylamino-PEG3-azide Chemical Properties,Usage,Production
Description
Methylamino-PEG3-azide is a PEG linker containing an azide group with a methylamine group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The methylamine group is reactive with carboxylic acids, carbonyls (ketone, aldehyde) etc.
Uses
Methylamino-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Methylamino-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Methylamino-PEG3-azide Preparation Products And Raw materials
Raw materials
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View Lastest Price from Methylamino-PEG3-azide manufacturers
- Product
- Methylamino-PEG3-azide 1355197-57-7
- Price
- US $0.00/mg
- Min. Order
- 100mg
- Purity
- >95.00%
- Supply Ability
- 100mg
- Release date
- 2024-03-22