FIT-039
- Product Name
- FIT-039
- CAS No.
- 1113044-49-7
- Chemical Name
- FIT-039
- Synonyms
- FIT-039;FIT-039 (FIT039);FIT-039, 10 mM in DMSO;N-[5-Fluoro-2-(1-piperidinyl)phenyl]-4-pyridinecarbothioamide;N-(5-fluoro-2-(piperidin-1-yl)phenyl)pyridine-4-carbothioamide;4-Pyridinecarbothioamide, N-[5-fluoro-2-(1-piperidinyl)phenyl]-;Cytomegalovirus,HSV-1,Herpes simplex virus,transcription,Inhibitor,DNA,CDK,Cyclin dependent kinase,CDK9,CMV,FIT 039,mRNA,FIT039,viruses,antiviral,inhibit,orally,FIT-039,polymerase-II,HSV-2,DNA/RNA Synthesis,HSV
- CBNumber
- CB73067546
- Molecular Formula
- C17H18FN3S
- Formula Weight
- 315.41
- MOL File
- 1113044-49-7.mol
FIT-039 Property
- storage temp.
- 2-8°C
- solubility
- DMSO:55.0(Max Conc. mg/mL);174.38(Max Conc. mM)
- form
- A solid
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- SML2861
- Product name
- FIT-039
- Purity
- ≥98% (HPLC)
- Packaging
- 5 mg
- Price
- $62.6
- Updated
- 2025/07/31
- Product number
- SML2861
- Product name
- FIT-039
- Purity
- ≥98% (HPLC)
- Packaging
- 25 mg
- Price
- $268
- Updated
- 2025/07/31
- Product number
- CS-0014657
- Product name
- FIT-039
- Purity
- ≥98.0%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- DC21015
- Product name
- FIT-039
- Purity
- >98%
- Packaging
- 100mg
- Price
- $700
- Updated
- 2021/12/16
- Product number
- DC21015
- Product name
- FIT-039
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1300
- Updated
- 2021/12/16
FIT-039 Chemical Properties,Usage,Production
Description
FIT-039 is a novel cyclin-dependent kinase 9 (CDK9) inhibitor, suppressing replication of a broad spectrum of DNA viruses through inhibition of mRNA transcription.
Uses
FIT-039 is a selective, ATP-competitive and orally active CDK9 inhibitor with an IC50 of 5.8 μM for CKD9/cyclin T1. FIT-039 does not inhibit other CDKs and other kinases. FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μM), HSV-2, human adenovirus, and human CMV. FIT-039 is a promising antiviral agent for inhibiting drug-resistant HSVs and other DNA viruses.
in vivo
Treatment with the FIT-039 ointment twice a day suppresses skin lesions and rescues mice (male BALB/c mice injected with HSV-1) from lethality in a dose-dependent manner. The healing of lesions is observed with 5% to 10% FIT-039 ointment, leading to the complete regression of zosteriform spread on day 10, which is also observed with the 5% ACV ointment[1].
FIT-039 does not affect body weight gain in mice administrated with an overdose of this compound (1000 mg/kg/d) for 14 days, and no changes are observed in biological markers in their blood[1].
target
FIT-039 is a selective, ATP-competitive and orally active CDK9 inhibitor with an IC50 of 5.8 μM for CKD9/cyclin T1. FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μM), HSV-2, human adenovirus, and human CMV.
IC 50
CDK9/cyclinT1: 5.8 μM (IC50); HSV-1: 0.69 μM (IC50); HSV-2; CMV
References
[1] Makoto Yamamoto, et al. CDK9 Inhibitor FIT-039 Prevents Replication of Multiple DNA Viruses. J Clin Invest. 2014 Aug;124(8):3479-88. DOI:10.1172/JCI73805
FIT-039 Preparation Products And Raw materials
Raw materials
Preparation Products
FIT-039 Suppliers
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- +1-781-999-5354; +17819995354
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- United States
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