TSI-01

Product Name: TSI-01
CAS No.: 704878-75-1
Chemical Name: TSI-01
Synonyms: TSI-01;isopropyl 4-(3,4-dichloro-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate;Benzoic acid, 4-(3,4-dichloro-2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-, 1-methylethyl ester
CBNumber: CB73067586
Molecular Formula: C14H11Cl2NO4
Formula Weight: 328.15
MOL File: 704878-75-1.mol

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TSI-01 Property

Melting point:: 150-152°C
storage temp.: Amber Vial, -20°C Freezer, Under inert atmosphere
solubility: DMSO (Slightly), Ethyl Acetate (Slightly)
form: Solid
color: Light Yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17628
Product name: TSI-01
Purity: ≥95%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 17628
Product name: TSI-01
Purity: ≥95%
Packaging: 5mg
Price: $216
Updated: 2024/03/01

Cayman Chemical

Product number: 17628
Product name: TSI-01
Purity: ≥95%
Packaging: 10mg
Price: $380
Updated: 2024/03/01

Cayman Chemical

Product number: 17628
Product name: TSI-01
Purity: ≥95%
Packaging: 25mg
Price: $830
Updated: 2024/03/01

TRC

Product number: T895525
Product name: TSI-01
Packaging: 100mg
Price: $1020
Updated: 2021/12/16

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TSI-01 Chemical Properties,Usage,Production

Description

Platelet-activating factor (PAF) is a pro-inflammatory phospholipid mediator that is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: lysophosphatidylcholine acyltransferase (LPCAT)1, which is mostly expressed in the lungs, and LPCAT2, which is expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC₅₀s = 0.47 versus 3.02 μM for human LPCAT2 and LPCAT1, respectively). At 60 μM it was shown to suppress PAF biosynthesis in mouse peritoneal macrophages stimulated with a calcium ionophore.

Uses

TSI-01 is a selectve inhibitor of LPCAT2, a platelet-activiating factor acetyltransferase (PAFAT) which acts as a pro-inflammatory phospholipid mediator. Inhibition leads to suppression of PAF biosynthesis.

TSI-01 Preparation Products And Raw materials

Raw materials

Preparation Products

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TSI-01 Suppliers

China 27 United Kingdom 1 United States 4 Global 32

BOC Sciences

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Pharmacodia (Beijing) Co.,Ltd

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Lynnchem

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Novachemistry

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TargetMol Chemicals Inc.

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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704878-75-1, TSI-01Related Search:

TSI-01

isopropyl 4-(3,4-dichloro-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate

Benzoic acid, 4-(3,4-dichloro-2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-, 1-methylethyl ester

704878-75-1