TSI-01
- Product Name
- TSI-01
- CAS No.
- 704878-75-1
- Chemical Name
- TSI-01
- Synonyms
- TSI-01;isopropyl 4-(3,4-dichloro-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate;Benzoic acid, 4-(3,4-dichloro-2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-, 1-methylethyl ester
- CBNumber
- CB73067586
- Molecular Formula
- C14H11Cl2NO4
- Formula Weight
- 328.15
- MOL File
- 704878-75-1.mol
TSI-01 Property
- Melting point:
- 150-152°C
- storage temp.
- Amber Vial, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Ethyl Acetate (Slightly)
- form
- Solid
- color
- Light Yellow
N-Bromosuccinimide Price
- Product number
- 17628
- Product name
- TSI-01
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 17628
- Product name
- TSI-01
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $216
- Updated
- 2024/03/01
- Product number
- 17628
- Product name
- TSI-01
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $380
- Updated
- 2024/03/01
- Product number
- 17628
- Product name
- TSI-01
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $830
- Updated
- 2024/03/01
- Product number
- T895525
- Product name
- TSI-01
- Packaging
- 100mg
- Price
- $1020
- Updated
- 2021/12/16
TSI-01 Chemical Properties,Usage,Production
Description
Platelet-activating factor (PAF) is a pro-inflammatory phospholipid mediator that is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: lysophosphatidylcholine acyltransferase (LPCAT)1, which is mostly expressed in the lungs, and LPCAT2, which is expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC50s = 0.47 versus 3.02 μM for human LPCAT2 and LPCAT1, respectively). At 60 μM it was shown to suppress PAF biosynthesis in mouse peritoneal macrophages stimulated with a calcium ionophore.
Uses
TSI-01 is a selectve inhibitor of LPCAT2, a platelet-activiating factor acetyltransferase (PAFAT) which acts as a pro-inflammatory phospholipid mediator. Inhibition leads to suppression of PAF biosynthesis.
TSI-01 Preparation Products And Raw materials
Raw materials
Preparation Products
TSI-01 Suppliers
- Tel
- 44-20819178-90 02081917890
- Fax
- (0)2080432064
- info@novachemistry.com
- Country
- United Kingdom
- ProdList
- 4381
- Advantage
- 58