Scopolamine Hydrobromide Trihydrate
- Product Name
- Scopolamine Hydrobromide Trihydrate
- CAS No.
- 6533-68-2
- Chemical Name
- Scopolamine Hydrobromide Trihydrate
- Synonyms
- screen;tripton;Benzeneacetic acid, .alpha.-(hydroxymethyl)-, (1.alpha.,2.beta.,4.beta.,5.alpha.,7.beta.)-9-methyl-3-oxa-9-azatricyclo3.3.1.02,4non-7-yl ester, hydrobromide, trihydrate, (.alpha.S)-;C17H21NO4BRH3H2O;Scopolamine CRS.;Scopolamine-d3.HBr;Tiotropium Impurity 21;),hydrobromide,trihydrate;East pol base hydrobromide;Scopolamine Hydrobromide RS
- CBNumber
- CB7311132
- Molecular Formula
- C17H24BrNO5
- Formula Weight
- 402.29
- MOL File
- 6533-68-2.mol
Scopolamine Hydrobromide Trihydrate Property
- Melting point:
- 197-194 °C
- refractive index
- -25.5 ° (C=5, H2O)
- storage temp.
- Poison room
- solubility
- H2O: soluble50mg/mL
- form
- Crystals or Crystalline Powder
- color
- white to off-white
- optical activity
- [α]25/D 24 to 26°, c = 5 in H2O(lit.)
- Merck
- 14,8406
- BRN
- 6100669
- Stability:
- Stable, but air and light sensitive. Incompatible with acids, bases, strong oxidizing agents. Slightly hygroscopic.
- LogP
- 0.760 (est)
- CAS DataBase Reference
- 6533-68-2(CAS DataBase Reference)
- EPA Substance Registry System
- Scopolamine hydrobromide trihydrate (6533-68-2)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P262Do not get in eyes, on skin, or on clothing.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- S0929
- Product name
- Scopolamine hydrobromide
- Purity
- meets USP testing specifications
- Packaging
- 1g
- Price
- $74.9
- Updated
- 2024/03/01
- Product number
- PHR1470
- Product name
- Scopolamine Hydrobromide
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 500mg
- Price
- $124
- Updated
- 2024/03/01
- Product number
- S1875
- Product name
- (?)-Scopolamine hydrobromide trihydrate
- Purity
- ≥98% (HPLC), powder
- Packaging
- 1g
- Price
- $77.4
- Updated
- 2024/03/01
- Product number
- S1875
- Product name
- (?)-Scopolamine hydrobromide trihydrate
- Purity
- ≥98% (HPLC), powder
- Packaging
- 5g
- Price
- $287
- Updated
- 2024/03/01
- Product number
- S1875
- Product name
- (?)-Scopolamine hydrobromide trihydrate
- Purity
- ≥98% (HPLC), powder
- Packaging
- 25g
- Price
- $975
- Updated
- 2024/03/01
Scopolamine Hydrobromide Trihydrate Chemical Properties,Usage,Production
Description
Scopolamine hydrobromide is a bronchodilator indicated for the maintenance treatment of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema, the maintenance treatment of concomitant dyspnea and the prevention of acute exacerbations.
Chemical Properties
white crystalline solid
Uses
Scopolamine is a nasal decongestant and adrenergic agonist that is used to dilate the pupil, reduce eye focusing ability, control saliva and gastric acid production, slow intestinal movements, and prevent vomiting.
Definition
ChEBI: Scopolamine hydrobromide trihydrate is a hydrate that is the trihydrate form of scopolamine hydrobromide. It has a role as a mydriatic agent, a muscarinic antagonist, an anaesthesia adjuvant, an antispasmodic drug and an antiemetic. It contains a scopolamine hydrobromide (anhydrous).
brand name
Isopto Hyoscine (Alcon); Transderm-Scop (Ciba-Geigy).
General Description
White orthorhombic sphenoidal crystals from water. pH of 0.05 molar solution: 5.85.
Air & Water Reactions
Is sensitive to air, light and moisture. Slightly efflorescent in dry air.
Reactivity Profile
SCOPOLAMINE HYDROBROMIDE TRIHYDRATE is incompatible with acids, bases and oxidizing agents. .
Fire Hazard
Flash point data for SCOPOLAMINE HYDROBROMIDE TRIHYDRATE are not available. SCOPOLAMINE HYDROBROMIDE TRIHYDRATE is probably combustible.
Mode of action
Scopolamine Hydrobromide[6533-68-2] is a Belladonna Alkaloid with Anticholinergic Activity. It competitively inhibits muscarinic receptors of the parasympathetic nervous system for acetylcholine and act as a nonselective muscarinic antagonist, producing peripheral anti-muscarinic, central sedative and antiemetic effects. The parasympatholytic scopolamine, structurally very similar to atropine as well, is used in conditions requiring decreased parasympathetic activity. Therefore, scopolamine can inhibit the secretion of saliva and sweat, decrease gastrointestinal secretions and motility, and increase heart rate et al.
References
[1] KLINKENBERGINGE BloklandArjan. The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies.[J]. Neuroscience and Biobehavioral Reviews, 2010. DOI:10.1016/j.neubiorev.2010.04.001.
[2] CEYHAN T, KARTAL M, ALTUN M L, et al. LC determination of atropine sulfate and scopolamine hydrobromide in pharmaceuticals.[J]. Journal of pharmaceutical and biomedical analysis, 2001, 25 3-4: 399-406. DOI:10.1016/S0731-7085(00)00514-8.
[3] STEENKAMPP A. Fatal Datura poisoning: identification of atropine and scopolamine by high performance liquid chromatography/photodiode array/mass spectrometry.[J]. Forensic science international, 2004. DOI:10.1016/j.forsciint.2004.03.011.
[4] MUHTADI F J, HASSAN M M A. Analytical Profile Of Scopolamine Hydrobromide[C]//Vol. 19. 1990: 477-551. DOI:10.1016/S0099-5428(08)60376-7.
Scopolamine Hydrobromide Trihydrate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Scopolamine Hydrobromide Trihydrate manufacturers
- Product
- Scopolamine Hydrobromide Trihydrate 6533-68-2
- Price
- US $0.00/KG
- Min. Order
- 100g
- Purity
- 98%+
- Supply Ability
- 100kg
- Release date
- 2020-10-22
- Product
- SCOPOLAMINE HYDROBROMIDE TRIHYDRATE 6533-68-2
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2023-10-20
- Product
- Scopolamine HBr trihydrate 6533-68-2
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 99%-102%;CP
- Supply Ability
- 1KG
- Release date
- 2021-06-07