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Scopolamine Hydrobromide Trihydrate

Product Name
Scopolamine Hydrobromide Trihydrate
CAS No.
6533-68-2
Chemical Name
Scopolamine Hydrobromide Trihydrate
Synonyms
screen;tripton;Benzeneacetic acid, .alpha.-(hydroxymethyl)-, (1.alpha.,2.beta.,4.beta.,5.alpha.,7.beta.)-9-methyl-3-oxa-9-azatricyclo3.3.1.02,4non-7-yl ester, hydrobromide, trihydrate, (.alpha.S)-;C17H21NO4BRH3H2O;Scopolamine CRS.;Scopolamine-d3.HBr;Tiotropium Impurity 21;),hydrobromide,trihydrate;East pol base hydrobromide;Scopolamine Hydrobromide RS
CBNumber
CB7311132
Molecular Formula
C17H24BrNO5
Formula Weight
402.29
MOL File
6533-68-2.mol
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Scopolamine Hydrobromide Trihydrate Property

Melting point:
197-194 °C
refractive index 
-25.5 ° (C=5, H2O)
storage temp. 
Poison room
solubility 
H2O: soluble50mg/mL
form 
Crystals or Crystalline Powder
color 
white to off-white
optical activity
[α]25/D 24 to 26°, c = 5 in H2O(lit.)
Merck 
14,8406
BRN 
6100669
Stability:
Stable, but air and light sensitive. Incompatible with acids, bases, strong oxidizing agents. Slightly hygroscopic.
LogP
0.760 (est)
CAS DataBase Reference
6533-68-2(CAS DataBase Reference)
EPA Substance Registry System
Scopolamine hydrobromide trihydrate (6533-68-2)
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Safety

Hazard Codes 
T+
Risk Statements 
26/27/28
Safety Statements 
45-25-1
RIDADR 
UN1544 6.1/PG 3
WGK Germany 
1
RTECS 
YM4550000
HazardClass 
6.1
PackingGroup 
III
HS Code 
29399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S0929
Product name
Scopolamine hydrobromide
Purity
meets USP testing specifications
Packaging
1g
Price
$74.9
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR1470
Product name
Scopolamine Hydrobromide
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
500mg
Price
$124
Updated
2024/03/01
Sigma-Aldrich
Product number
S1875
Product name
(?)-Scopolamine hydrobromide trihydrate
Purity
≥98% (HPLC), powder
Packaging
1g
Price
$77.4
Updated
2024/03/01
Sigma-Aldrich
Product number
S1875
Product name
(?)-Scopolamine hydrobromide trihydrate
Purity
≥98% (HPLC), powder
Packaging
5g
Price
$287
Updated
2024/03/01
Sigma-Aldrich
Product number
S1875
Product name
(?)-Scopolamine hydrobromide trihydrate
Purity
≥98% (HPLC), powder
Packaging
25g
Price
$975
Updated
2024/03/01
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Scopolamine Hydrobromide Trihydrate Chemical Properties,Usage,Production

Description

Scopolamine hydrobromide is a bronchodilator indicated for the maintenance treatment of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema, the maintenance treatment of concomitant dyspnea and the prevention of acute exacerbations.

Chemical Properties

white crystalline solid

Uses

Scopolamine is a nasal decongestant and adrenergic agonist that is used to dilate the pupil, reduce eye focusing ability, control saliva and gastric acid production, slow intestinal movements, and prevent vomiting.

Definition

ChEBI: Scopolamine hydrobromide trihydrate is a hydrate that is the trihydrate form of scopolamine hydrobromide. It has a role as a mydriatic agent, a muscarinic antagonist, an anaesthesia adjuvant, an antispasmodic drug and an antiemetic. It contains a scopolamine hydrobromide (anhydrous).

brand name

Isopto Hyoscine (Alcon); Transderm-Scop (Ciba-Geigy).

General Description

White orthorhombic sphenoidal crystals from water. pH of 0.05 molar solution: 5.85.

Air & Water Reactions

Is sensitive to air, light and moisture. Slightly efflorescent in dry air.

Reactivity Profile

SCOPOLAMINE HYDROBROMIDE TRIHYDRATE is incompatible with acids, bases and oxidizing agents. .

Fire Hazard

Flash point data for SCOPOLAMINE HYDROBROMIDE TRIHYDRATE are not available. SCOPOLAMINE HYDROBROMIDE TRIHYDRATE is probably combustible.

Mode of action

Scopolamine Hydrobromide[6533-68-2] is a Belladonna Alkaloid with Anticholinergic Activity. It competitively inhibits muscarinic receptors of the parasympathetic nervous system for acetylcholine and act as a nonselective muscarinic antagonist, producing peripheral anti-muscarinic, central sedative and antiemetic effects. The parasympatholytic scopolamine, structurally very similar to atropine as well, is used in conditions requiring decreased parasympathetic activity. Therefore, scopolamine can inhibit the secretion of saliva and sweat, decrease gastrointestinal secretions and motility, and increase heart rate et al.

References

[1] KLINKENBERGINGE BloklandArjan. The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies.[J]. Neuroscience and Biobehavioral Reviews, 2010. DOI:10.1016/j.neubiorev.2010.04.001.
[2] CEYHAN T, KARTAL M, ALTUN M L, et al. LC determination of atropine sulfate and scopolamine hydrobromide in pharmaceuticals.[J]. Journal of pharmaceutical and biomedical analysis, 2001, 25 3-4: 399-406. DOI:10.1016/S0731-7085(00)00514-8.
[3] STEENKAMPP A. Fatal Datura poisoning: identification of atropine and scopolamine by high performance liquid chromatography/photodiode array/mass spectrometry.[J]. Forensic science international, 2004. DOI:10.1016/j.forsciint.2004.03.011.
[4] MUHTADI F J, HASSAN M M A. Analytical Profile Of Scopolamine Hydrobromide[C]//Vol. 19. 1990: 477-551. DOI:10.1016/S0099-5428(08)60376-7.

Scopolamine Hydrobromide Trihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Scopolamine Hydrobromide Trihydrate Suppliers

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View Lastest Price from Scopolamine Hydrobromide Trihydrate manufacturers

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Scopolamine Hydrobromide Trihydrate 6533-68-2
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-10-22
Hebei Yanxi Chemical Co., Ltd.
Product
SCOPOLAMINE HYDROBROMIDE TRIHYDRATE 6533-68-2
Price
US $50.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10000
Release date
2023-10-20
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Scopolamine HBr trihydrate 6533-68-2
Price
US $0.00/g
Min. Order
1g
Purity
99%-102%;CP
Supply Ability
1KG
Release date
2021-06-07

6533-68-2, Scopolamine Hydrobromide TrihydrateRelated Search:

Scopolamine Methscopolamine bromide Scopolamine butylbromide SCOPOLAMINE N-OXIDE HYDROBROMIDE HYOSCINE N BUTYL BROMIDE BP Scopolamine hydrobromide Scopine HYOSCINE HYDROCHLORIDE ATROPINE-D3 98 ATOM % D Scopolamine Hydrobromide Trihydrate ANISODAMINE HYDROBROMIDE SCOPOLAMINE-D3 HBR 3H2O (N-METHYL-D3) HYOSCYAMINE HYDROBROMIDE

  • (-)-SCOPOLAMINE HYDROBROMIDE TRIHYDRATE
  • Benzeneacetic acid, .alpha.-(hydroxymethyl)-, (1.alpha.,2.beta.,4.beta.,5.alpha.,7.beta.)-9-methyl-3-oxa-9-azatricyclo3.3.1.02,4non-7-yl ester, hydrobromide, trihydrate, (.alpha.S)-
  • SCOPOLAMINEHYDROBROMIDE,TRIHYDRATE,USP
  • (-)-Scopolamine trihydrate hydrobromide, Hyoscine hydrobromide, Scopine tropate
  • (-)-Scopolamine trihydrate hydrobromide
  • Hyoscine hydrobromide, Scopine tropate
  • Scopolamine-d3.HBr
  • (-)-Scopolamine hydrobromide trihydrate Hydrobromide Trihydrate
  • ScopolaMine HBr (Hyoscine HBr)
  • Benzeneacetic acid, a-(hydroxyMethyl)-, (1a,2b,4b,5a,7b)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-ylester, hydrobroMide, hydrate (1:1:3), (aS)-
  • Scopolamine Hydrobromide (250 mg)
  • ScopolaMine-d3.HBr (Hyoscine-d3 HBr)
  • Scopolamine hydrobromide trihydrate, 99%, from Datura metel L.
  • C17H21NO4BRH3H2O
  • SCOPOLAMINE HYDROBROMIDE TRIHYDRATE
  • ),hydrobromide,trihydrate
  • screen
  • tripton
  • ATROSCINE HYDROBROMIDE TRIHYDRATE
  • HYOSCINE HYDROBROMIDE TRIHYDRATE
  • SCOPOLAMINE HYDROBROMIDE USP
  • ScopolamineHydrobromideTrihydrate99%
  • Scopolaminhydrobromidetrihydrate
  • (1S,2R,4S,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]non-7-yl 3-hydroxy-2-phenylpropanoate hydrobromide trihydrate
  • 9-methyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]non-7-yl 3-hydroxy-2-phenylpropanoate
  • (1S,2R,4S,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]non-7-yl 3-hydroxy-2-phenylpropanoate hydrobromid
  • (1R,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]non-7-yl (2S)-3-hydroxy-2-phenylpropanoate hydrobromide trihydrate
  • (1S,2R,4S,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]non-7-yl (2S)-3-hydroxy-2-phenylpropanoatato hydrobromide trihydrate
  • (-)-Scopolamine hydrobromide trihydrate Hydrobromide Trihydrate, ≥99%
  • Scopolamine Hydrobromide RS
  • Hyoscine hydrobromide trihydrate【(-)-Scopolamine hydrobromide trihydrate】
  • (-)-ScopolaminehydrobromidetrihydrateHydrobromideTrihydrate
  • East pol base hydrobromide
  • (1R,2R,4S,5S,7R)-9-methyl-3-oxa-9-azatricyclo[3.3 .1.0,2,4]nonan-7-yl (2S)-3-hydroxy-2-phenylpropanoate trihydrate hydrobromide
  • (1R,2R,4S,5S,7s)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl (S)-3-hydroxy-2-phenylpropanoate hydrobromide trihydrate
  • Scopolamine Hydrobromide TrihydrateQ: What is Scopolamine Hydrobromide Trihydrate Q: What is the CAS Number of Scopolamine Hydrobromide Trihydrate Q: What is the storage condition of Scopolamine Hydrobromide Trihydrate Q: What are the applications of Scopolamine Hydrobromide Trihydrate
  • Benzeneacetic acid, a-(hydroxymethyl)-,(1a,2b,4b,5a,7b)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester,hydrobromide, trihydrate, (aS)-
  • hydrogen (1S,2R,4S,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,]nonan-7-yl (2S)-3-hydroxy-2-phenylpropanoate trihydrate bromide
  • Scopolamine Hydrobromide (1610001)
  • (1S,2R,4S,5S,7R)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl (S)-3-hydroxy-2-phenylpropanoate hydrobromide trihydrate
  • Atropine Impurity F as Hydrobromide Trihydrate
  • Hyoscine Butylbromide Impurity A as Hydrobromide Trihydrate
  • Atropine EP Impurity F as Hydrobromide Trihydrate
  • Hyoscyamine Sulfate Impurity D
  • Hyoscine Butylbromide EP Impurity A as Hydrobromide Trihydrate
  • Hyoscyamine Sulfate EP Impurity D
  • Hyoscyamine Sulfate EP Impurity D as Hydrobromide Trihydrate
  • Hyoscyamine Sulfate Impurity D as Hydrobromide Trihydrate
  • Atropine Impurity F (Hyoscine)
  • Scopolamine CRS.
  • Tiotropium Impurity 21
  • Hyoscine Hydrobromide / Scopolamine Hydrobromide Trihydrate
  • 6533-68-2
  • 65333-68-2
  • C17H22BrNO43H2O
  • C17H18D3NO4HBr
  • C17H28BrNO7
  • C17H21NO4HBr3H2O