ALA-TYR-PRO-GLY-LYS-PHE-NH2 TRIFLUOROACETATE SALT
- Product Name
- ALA-TYR-PRO-GLY-LYS-PHE-NH2 TRIFLUOROACETATE SALT
- Chemical Name
- ALA-TYR-PRO-GLY-LYS-PHE-NH2 TRIFLUOROACETATE SALT
- Synonyms
- PAR4-AP TFA SALT;AYPGKF-NH2 TFA SALT;AYPGKF-NH2, PAR4-AP;ALA-TYR-PRO-GLY-LYS-PHE-NH2 TRIFLUOROACETATE SALT
- CBNumber
- CB7311521
- Molecular Formula
- C36H49F3N8O9
- Formula Weight
- 794.82
- MOL File
- Mol file
ALA-TYR-PRO-GLY-LYS-PHE-NH2 TRIFLUOROACETATE SALT Property
- storage temp.
- -20°C
- solubility
- H2O: >10mg/mL
- form
- solid
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- A3227
- Product name
- Ala-Tyr-Pro-Gly-Lys-Phe-NH2 trifluoroacetate salt
- Purity
- ≥98% (HPLC), solid
- Packaging
- 1mg
- Price
- $205
- Updated
- 2024/03/01
- Product number
- HCH0066723
- Product name
- ALA-TYR-PRO-GLY-LYS-PHE-NH2 TRIFLUOROACETATE SALT
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $693.69
- Updated
- 2021/12/16
ALA-TYR-PRO-GLY-LYS-PHE-NH2 TRIFLUOROACETATE SALT Chemical Properties,Usage,Production
Uses
4-Androsten-11β-ol-3,17-dione has been used in platelet aggregation.
General Description
Ala-Tyr-Pro-Gly-Lys-Phe-NH2 (AYPGKF- NH2) is a selective, specific proteinase-activated receptor 4 (PAR4) agonist peptide. PAR4 is a G-protein-coupled receptor that is expressed on the surface of human platelets and is involved in the thrombin signaling pathway. Cleavage of PAR4 by the protease thrombin stimulates the receptor and results in signaling of platelet aggregation.
Biochem/physiol Actions
AYPGK is a ligand for the PAR4 receptor; binding results in activation of PAR4. AYPGK stimulates platelet aggregation in vitro (EC50 =15 μM) via PAR4. In human platelets treated with the PAR4 agonist, AYPGKF stimulates the production of thromboxane, a potent agent for platelet-aggregation. Additionally, AYPGKF mediates the thrombin-induced release of endostatin from rat platelets.