3BDO

Product Name: 3BDO
CAS No.: 890405-51-3
Chemical Name: 3BDO
Synonyms: 3BDO;3BDO ，S8317;3BDO >=98% (HPLC);3BDO, 10 mM in DMSO;3-benzyl-5-[(2-nitrophenoxy)methyl]oxolan-2-one;3BDO, 97%, Activator for mTOR, Autophagy inhibitor;3-Benzyl-5-((2-nitrophenoxy)methyl)dihydrofuran-2(3H)-one;Pentonic acid, 2,3-dideoxy-5-O-(2-nitrophenyl)-2-(phenylmethyl)-, γ-lactone;Autophagy,3BDO,mTOR,Apoptosis,Mammalian target of Rapamycin,Inhibitor,inhibit
CBNumber: CB73117166
Molecular Formula: C18H17NO5
Formula Weight: 327.33
MOL File: 890405-51-3.mol

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3BDO Property

storage temp.: 2-8°C
solubility: DMSO: 65 mg/ml
form: oil
color: colorless to light brown
InChI: 1S/C18H17NO5/c20-18-14(10-13-6-2-1-3-7-13)11-15(24-18)12-23-17-9-5-4-8-16(17)19(21)22/h1-9,14-15H,10-12H2
InChIKey: AXPZIVKEZRHGAS-UHFFFAOYSA-N
SMILES: O=C1OC(COC2=C([N+]([O-])=O)C=CC=C2)CC1CC3=CC=CC=C3

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Safety

WGK Germany: WGK 3
HS Code: 29321900
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1687
Product name: 3BDO
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $100
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1687
Product name: 3BDO
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $402
Updated: 2025/07/31

ChemScene

Product number: CS-0035372
Product name: 3BDO
Purity: 99.91%
Packaging: 10mg
Price: $110
Updated: 2021/12/16

ChemScene

Product number: CS-0035372
Product name: 3BDO
Purity: 99.91%
Packaging: 5mg
Price: $70
Updated: 2021/12/16

ChemScene

Product number: CS-0035372
Product name: 3BDO
Purity: 99.91%
Packaging: 25mg
Price: $240
Updated: 2021/12/16

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3BDO Chemical Properties,Usage,Production

Uses

3BDO has been used to investigate the potential effects of metformin on inflammatory lung injury.

Biochem/physiol Actions

3BDO is a cell-permeable, orally bioavailable, non-toxic butyrolactone derivative that is shown to competitively bind FKBP1A (FK506-binding protein 1A, 12 kDa) in a reversible manner, and suppress autophagy via the mTOR pathway. 3BDO inhibits both LPS- and oxLDL-induced autophagy in HUVECs, increases TIA1 phosphorylation, and reduces autophagosomes number. It is reported to be brain permeant, and significantly decreases atherosclerosis development in apoE-/-?mice (100 mg/kg, q.d., p.o.). 3BDO increases IDE and neprilysin levels, lowers amyloid-β deposition in an AβPP/PS1 transgenic mouse model of Alzheimer′s disease, and alleviates memory deficits.

in vivo

Immunofluorescence assay reveals that 3BDO treatment increases the level of p-p70S6K and decreases the protein level of ATG13 in plaque endothelium of mice. 3BDO does not affect the phosphorylation of mTOR direct downstream targets p70S6K and 4EBP1. As compare with controls, apoE^-/- mice show inhibited endothelium autophagy and apoptosis with 3BDO treatment, so 3BDO protects against endothelium injury in atherosclerosis. 3BDO treatment stabilizes established atherosclerotic lesions in apoE^-/- mice. In apoE^-/-mice, as compare with controls, with 3BDO treatment, the serum level of IL-6 and IL-8 is significantly decreased^[2].

IC 50

mTOR

3BDO Preparation Products And Raw materials

Raw materials

Preparation Products

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3BDO Suppliers

China 68 United States 8 Global 76

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185;
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3505
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 40000
Advantage: 60

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Aikon International Limited

Tel: 025-58851090 15955137747
Fax: (6)02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15949
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3282
Advantage: 58

890405-51-3, 3BDORelated Search:

3BDO

3BDO, 97%, Activator for mTOR, Autophagy inhibitor

Pentonic acid, 2,3-dideoxy-5-O-(2-nitrophenyl)-2-(phenylmethyl)-, γ-lactone

3BDO >=98% (HPLC)

3-Benzyl-5-((2-nitrophenoxy)methyl)dihydrofuran-2(3H)-one

Autophagy,3BDO,mTOR,Apoptosis,Mammalian target of Rapamycin,Inhibitor,inhibit

3-benzyl-5-[(2-nitrophenoxy)methyl]oxolan-2-one

3BDO, 10 mM in DMSO

3BDO ，S8317

890405-51-3