3BDO

Product Name: 3BDO
CAS No.: 890405-51-3
Chemical Name: 3BDO
Synonyms: 3BDO;3BDO >=98% (HPLC);3-benzyl-5-[(2-nitrophenoxy)methyl]oxolan-2-one;3BDO, 97%, Activator for mTOR, Autophagy inhibitor;3-Benzyl-5-((2-nitrophenoxy)methyl)dihydrofuran-2(3H)-one;Pentonic acid, 2,3-dideoxy-5-O-(2-nitrophenyl)-2-(phenylmethyl)-, γ-lactone;Autophagy,3BDO,mTOR,Apoptosis,Mammalian target of Rapamycin,Inhibitor,inhibit
CBNumber: CB73117166
Molecular Formula: C18H17NO5
Formula Weight: 327.33
MOL File: 890405-51-3.mol

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3BDO Property

storage temp.: 2-8°C
solubility: DMSO: 65 mg/ml
form: oil
color: colorless to light brown

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Safety

HS Code: 29321900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1687
Product name: 3BDO
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $110
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1687
Product name: 3BDO
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $440
Updated: 2023/06/20

ChemScene

Product number: CS-0035372
Product name: 3BDO
Purity: 99.91%
Packaging: 5mg
Price: $70
Updated: 2021/12/16

ChemScene

Product number: CS-0035372
Product name: 3BDO
Purity: 99.91%
Packaging: 10mg
Price: $110
Updated: 2021/12/16

ChemScene

Product number: CS-0035372
Product name: 3BDO
Purity: 99.91%
Packaging: 25mg
Price: $240
Updated: 2021/12/16

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3BDO Chemical Properties,Usage,Production

Uses

3BDO has been used to investigate the potential effects of metformin on inflammatory lung injury.

Biochem/physiol Actions

3BDO is a cell-permeable, orally bioavailable, non-toxic butyrolactone derivative that is shown to competitively bind FKBP1A (FK506-binding protein 1A, 12 kDa) in a reversible manner, and suppress autophagy via the mTOR pathway. 3BDO inhibits both LPS- and oxLDL-induced autophagy in HUVECs, increases TIA1 phosphorylation, and reduces autophagosomes number. It is reported to be brain permeant, and significantly decreases atherosclerosis development in apoE-/-?mice (100 mg/kg, q.d., p.o.). 3BDO increases IDE and neprilysin levels, lowers amyloid-β deposition in an AβPP/PS1 transgenic mouse model of Alzheimer′s disease, and alleviates memory deficits.

3BDO Preparation Products And Raw materials

Raw materials

Preparation Products

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3BDO Suppliers

China 44 United States 8 Global 52

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14055
Advantage: 65

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3466
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Aikon International Limited

Tel: 025-58851090 13611564524
Fax: (6)02557626880
Email: lwan@aikonchem.com
Country: China
ProdList: 15951
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3251
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Guangzhou Tomums Life Science Co., Ltd.

Tel: 020-31155029 18902330969
Fax: 020-31155029
Email: sales@tomums.cn
Country: China
ProdList: 4696
Advantage: 58

890405-51-3, 3BDORelated Search:

3BDO

3BDO, 97%, Activator for mTOR, Autophagy inhibitor

Pentonic acid, 2,3-dideoxy-5-O-(2-nitrophenyl)-2-(phenylmethyl)-, γ-lactone

3BDO >=98% (HPLC)

3-Benzyl-5-((2-nitrophenoxy)methyl)dihydrofuran-2(3H)-one

Autophagy,3BDO,mTOR,Apoptosis,Mammalian target of Rapamycin,Inhibitor,inhibit

3-benzyl-5-[(2-nitrophenoxy)methyl]oxolan-2-one

890405-51-3