3BDO

Product Name: 3BDO
CAS No.: 890405-51-3
Chemical Name: 3BDO
Synonyms: 3BDO;3BDO >=98% (HPLC);3-benzyl-5-[(2-nitrophenoxy)methyl]oxolan-2-one;3BDO, 97%, Activator for mTOR, Autophagy inhibitor;3-Benzyl-5-((2-nitrophenoxy)methyl)dihydrofuran-2(3H)-one;Pentonic acid, 2,3-dideoxy-5-O-(2-nitrophenyl)-2-(phenylmethyl)-, γ-lactone;Autophagy,3BDO,mTOR,Apoptosis,Mammalian target of Rapamycin,Inhibitor,inhibit
CBNumber: CB73117166
Molecular Formula: C18H17NO5
Formula Weight: 327.33
MOL File: 890405-51-3.mol

More

Less

3BDO Property

storage temp.: 2-8°C
solubility: DMSO: 65 mg/ml
form: oil
color: colorless to light brown

More

Less

Safety

HS Code: 29321900

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1687
Product name: 3BDO
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $110
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1687
Product name: 3BDO
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $440
Updated: 2023/06/20

ChemScene

Product number: CS-0035372
Product name: 3BDO
Purity: 99.91%
Packaging: 5mg
Price: $70
Updated: 2021/12/16

ChemScene

Product number: CS-0035372
Product name: 3BDO
Purity: 99.91%
Packaging: 10mg
Price: $110
Updated: 2021/12/16

ChemScene

Product number: CS-0035372
Product name: 3BDO
Purity: 99.91%
Packaging: 25mg
Price: $240
Updated: 2021/12/16

More

Less

3BDO Chemical Properties,Usage,Production

Uses

3BDO has been used to investigate the potential effects of metformin on inflammatory lung injury.

Biochem/physiol Actions

3BDO is a cell-permeable, orally bioavailable, non-toxic butyrolactone derivative that is shown to competitively bind FKBP1A (FK506-binding protein 1A, 12 kDa) in a reversible manner, and suppress autophagy via the mTOR pathway. 3BDO inhibits both LPS- and oxLDL-induced autophagy in HUVECs, increases TIA1 phosphorylation, and reduces autophagosomes number. It is reported to be brain permeant, and significantly decreases atherosclerosis development in apoE-/-?mice (100 mg/kg, q.d., p.o.). 3BDO increases IDE and neprilysin levels, lowers amyloid-β deposition in an AβPP/PS1 transgenic mouse model of Alzheimer′s disease, and alleviates memory deficits.

3BDO Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

3BDO Suppliers

China 44 United States 8 Global 52

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14055
Advantage: 65

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3466
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8014
Advantage: 62

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Aikon International Limited

Tel: 025-58851090 13611564524
Fax: (6)02557626880
Email: lwan@aikonchem.com
Country: China
ProdList: 15951
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3249
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Guangzhou Tomums Life Science Co., Ltd.

Tel: 020-31155029 18902330969
Fax: 020-31155029
Email: sales@tomums.cn
Country: China
ProdList: 4696
Advantage: 58

890405-51-3, 3BDORelated Search:

3BDO

3BDO, 97%, Activator for mTOR, Autophagy inhibitor

Pentonic acid, 2,3-dideoxy-5-O-(2-nitrophenyl)-2-(phenylmethyl)-, γ-lactone

3BDO >=98% (HPLC)

3-Benzyl-5-((2-nitrophenoxy)methyl)dihydrofuran-2(3H)-one

Autophagy,3BDO,mTOR,Apoptosis,Mammalian target of Rapamycin,Inhibitor,inhibit

3-benzyl-5-[(2-nitrophenoxy)methyl]oxolan-2-one

890405-51-3