Ezutromid
Uses- Product Name
- Ezutromid
- CAS No.
- 945531-77-1
- Chemical Name
- Ezutromid
- Synonyms
- CS-2334;BMN-195;SMT C1100;Ezutromid;VOX-C1100;VOX C1100;Ezutromid, 10 mM in DMSO;Ezutromid (BMN-195, SMTC-1100);5-(Ethylsulfonyl)-2-(2-naphthalenyl)benzoxazole;Benzoxazole, 5-(ethylsulfonyl)-2-(2-naphthalenyl)-
- CBNumber
- CB73133346
- Molecular Formula
- C19H15NO3S
- Formula Weight
- 337.39
- MOL File
- 945531-77-1.mol
Ezutromid Property
- storage temp.
- Store at -20°C
- solubility
- DMSO:6.5(Max Conc. mg/mL);19.27(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.89(Max Conc. mM)
DMF:2.0(Max Conc. mg/mL);5.93(Max Conc. mM) - form
- A crystalline solid
- color
- Light yellow to yellow
- InChI
- InChI=1S/C19H15NO3S/c1-2-24(21,22)16-9-10-18-17(12-16)20-19(23-18)15-8-7-13-5-3-4-6-14(13)11-15/h3-12H,2H2,1H3
- InChIKey
- KSGCNXAZROJSNW-UHFFFAOYSA-N
- SMILES
- O1C2=CC=C(S(CC)(=O)=O)C=C2N=C1C1=CC=C2C(=C1)C=CC=C2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 20309
- Product name
- Ezutromid
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $33
- Updated
- 2024/03/01
- Product number
- 20309
- Product name
- Ezutromid
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $143
- Updated
- 2024/03/01
- Product number
- 20309
- Product name
- Ezutromid
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $254
- Updated
- 2024/03/01
- Product number
- 20309
- Product name
- Ezutromid
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $553
- Updated
- 2024/03/01
- Product number
- 2805DC
- Product name
- Ezutromid
- Packaging
- 5mg
- Price
- $257
- Updated
- 2021/12/16
Ezutromid Chemical Properties,Usage,Production
Uses
5-(Ethylsulfonyl)-2-(naphthalen-2-yl)benzo[D] oxazole is a useful research chemical compound.
Uses
Ezutromid (SMT C1100) is a first-in-class, orally active benzoxazole utrophin modulator with an EC50 of 0.91 μM. Ezutromid can be used for the research Duchenne muscular dystrophy (DMD). Ezutromid inhibits CYP1A2 enzymic activity in human liver microsomes (HLM) with an IC50 of 5.4 μM[1][2].
in vivo
Note: You can dissolve the products in phosphate buffered saline (PBS), 0.1% Tween-20, 5% DMSO)
IC 50
CYP1
References
[1] Chancellor DR, et al. Discovery of 2-arylbenzoxazoles as upregulators of utrophin production for the treatment of Duchenne muscular dystrophy. J Med Chem. 2011;54(9):3241-3250. DOI:10.1021/jm200135z
[2] Chatzopoulou M, et al. Isolation, Structural Identification, Synthesis, and Pharmacological Profiling of 1,2-trans-Dihydro-1,2-diol Metabolites of the Utrophin Modulator Ezutromid. J Med Chem. 2020;63(5):2547-2556. DOI:10.1021/acs.jmedchem.9b01547
[3] Tinsley JM et al. Daily treatment with SMTC1100, a novel small molecule utrophin upregulator, dramatically reduces the dystrophic symptoms in the mdx mouse. PLoS One. 2011 May 6;6(5):e19189. DOI:10.1371/journal.pone.0019189
[4] Tinsley J et al. Safety, tolerability, and pharmacokinetics of SMT C1100, a 2-arylbenzoxazole utrophin modulator, following single- and multiple-dose administration to healthy male adult volunteers. J Clin Pharmacol. 2015 Jun;55(6):698-707. DOI:10.1002/jcph.468
[5] Guiraud S et al. Second-generation compound for the modulation of utrophin in the therapy of DMD. Hum Mol Genet. 2015 Aug 1;24(15):4212-24. DOI:10.1093/hmg/ddv154
Ezutromid Preparation Products And Raw materials
Raw materials
Preparation Products
Ezutromid Suppliers
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- 021-58955995
- Fax
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- United States
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View Lastest Price from Ezutromid manufacturers
- Product
- Ezutromid 945531-77-1
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-12