NDI-010976

Product Name: NDI-010976
CAS No.: 1434635-54-7
Chemical Name: NDI-010976
Synonyms: N-654;ND-630;GS0976;CS-2609;CS-2632;CPDB5078;EOS-61252;NDI-010976;Firsocostat;GS0976,ND-630
CBNumber: CB73133386
Molecular Formula: C28H31N3O8S
Formula Weight: 569.63
MOL File: 1434635-54-7.mol

More

Less

NDI-010976 Property

Boiling point:: 779.0±70.0 °C(Predicted)
Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:75.0(Max Conc. mg/mL);131.66(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);17.56(Max Conc. mM)
Ethanol:3.0(Max Conc. mg/mL);5.27(Max Conc. mM)
form: A crystalline solid
pka: 3.66±0.10(Predicted)
color: White to light yellow
InChIKey: ZZWWXIBKLBMSCS-XKGZFIRZNA-N
SMILES: C(O)(=O)C(N1C(=O)N(C[C@@H](C2=CC=CC=C2OC)OC2CCOCC2)C2SC(C3=NC=CO3)=C(C)C=2C1=O)(C)C |&1:9,r|

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 23961
Product name: ND-630
Purity: ≥98%
Packaging: 1mg
Price: $364
Updated: 2024/03/01

Cayman Chemical

Product number: 23961
Product name: ND-630
Purity: ≥98%
Packaging: 5mg
Price: $1181
Updated: 2024/03/01

ChemScene

Product number: CS-6509
Product name: Firsocostat
Purity: 99.48%
Packaging: 5mg
Price: $270
Updated: 2021/12/16

ChemScene

Product number: CS-6509
Product name: Firsocostat
Purity: 99.48%
Packaging: 10mg
Price: $450
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0005695
Product name: (R)-2-(1-(2-(2-METHOXYPHENYL)-2-((TETRAHYDRO-2H-PYRAN-4-YL)OXY)ETHYL)-5-METHYL-6-(OXAZOL-2-YL)-2,4-DIOXO-1,2-DIHYDROTHIENO[2,3-D]PYRIMIDIN-3(4H)-YL)-2-METHYLPROPANOIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $497.67
Updated: 2021/12/16

More

Less

NDI-010976 Chemical Properties,Usage,Production

Description

ND-630 is an allosteric inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits ACC1 and ACC2 activity (IC₅₀s = 2.1 and 6.1 nM, respectively, for the human enzymes). It is selective for ACC over 101 enzymes, receptors, growth factors, transporters, and ion channels up to a concentration of 10 μM. ND-630 prevents dimerization of ACC by interacting within the phosphopeptide-acceptor and dimerization site. It reduces fatty acid synthesis (EC₅₀s = 66 and 9 nM in 10% FBS and serum-free media, respectively) and increases fatty acid oxidation in HepG2 cells. ND-630 reduces hepatic steatosis in a rat model of diet-induced obesity and in Zucker diabetic rats. It also improves insulin secretion stimulated by glucose and reduces hemoglobin A1c levels by 0.9% in Zucker diabetic rats.

Uses

Firsocostat or ND-630 (CAS# 1434635-54-7) is an inhibitor of acetyl-coA carboxylase and may favorably affect the morbidity and mortality associated with obesity, diabetes, and fatty liver disease from reduced hepatic steatosis, improved insulin sensitivity, and modulation of dyslipidemia.

in vivo

Chronical administration of Firsocostat (ND-630) to rats with diet-induced obesity reduces hepatic steatosis, improves insulin sensitivity, reduces weight gain without affecting food intake, and favorably affects dyslipidemia. Chronical administration of Firsocostat Zucker diabetic fatty rats, Firsocostat reduces hepatic steatosis, improves glucose-stimulated insulin secretion, and reduces hemoglobin A1c (0.9% reduction). Firsocostat exhibits an aqueous solubility of 594 μM and human and rat plasma protein binding of 98.5% and 98.6%, respectively. Pharmacokinetic evaluation of Firsocostat in male Sprague-Dawley rats [i.v. 3 mg/kg; orally (p.o.) 10 mg/kg] yields a plasma t_1/2 of 4.5 h, bioavailability of 37%, clearance of 33 mL/min/kg, volume of distribution of 1.9 L/kg, oral time of maximum plasma concentration of 0.25 h^[1].

References

[1] G. HARRIMAN. Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats[J]. Proceedings of the National Academy of Sciences, 2016, 43 1: E1796-E1805. DOI: 10.1073/pnas.1520686113

NDI-010976 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

NDI-010976 Suppliers

China 106 United States 9 Global 115

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3506
Advantage: 58

Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd

Tel: 15317229551
Fax: QQ:3607245178
Email: 15151849396@163.com
Country: China
ProdList: 989
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

Syncozymes (Shanghai) Co.,Ltd.

Tel: 021-68187180 13681683526
Fax: 021-68187179
Email: lchen@syncozymes.com
Country: China
ProdList: 317
Advantage: 55

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9637
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

More

Less

View Lastest Price from NDI-010976 manufacturers

Honest Joy Holdings Limited

Product: NDI-010976 1434635-54-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.4%
Supply Ability: 100 tons
Release date: 2022-01-13

Career Henan Chemical Co

Product: NDI-010976 1434635-54-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kG
Release date: 2019-07-04

1434635-54-7, NDI-010976Related Search:

AC-262,356 ND-646 Remdesivir 2137975-08-5 CU-CPT-8m CU-CPT-9a GW-870086

NDI-010976

(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl)-2-methylpropanoicacid

ND-630

(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,2-dihydrothieno[2,3-d]pyrimidin-3(4H)-yl)-2-methylpropanoic acid

EOS-61252

GS0976

CPDB5078

(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,2-dihydrothieno[2,3-

GS0976,ND-630

1,4-Dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxothieno[2,3-d]pyrimidine-3(2H)-acetic acid

ND-630,NDI-010976

Firsocostat

Firsocostat(ND-630,GS-0976)

CS-2609

CS-2632

ND 630; ND630;GS-0976;GS 0976;GS0976;FIRSOCOSTAT

Firsocostat (GS-0976,NDI-010976,ND-630)

ND630;FIRSOCOSTAT

Firsocostat (ND-630

Thieno[2,3-d]pyrimidine-3(2H)-acetic acid, 1,4-dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxo-

ND-630（GS0976）

Firsocostat (GS-0976)

ND-630|||NDI-010976|||GS-0976

Firsocostat, 10 mM in DMSO

N-654

Firsocostat (GS-0976, ND-630)

Firsocostat (GS-0976) ，S8893

1434635-54-7

API