NDI-010976

Product Name: NDI-010976
CAS No.: 1434635-54-7
Chemical Name: NDI-010976
Synonyms: ND-630;GS0976;CS-2609;CS-2632;CPDB5078;EOS-61252;NDI-010976;Firsocostat;GS0976,ND-630;ND-630（GS0976）
CBNumber: CB73133386
Molecular Formula: C28H31N3O8S
Formula Weight: 569.63
MOL File: 1434635-54-7.mol

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NDI-010976 Property

Boiling point:: 779.0±70.0 °C(Predicted)
Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:75.0(Max Conc. mg/mL);131.66(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);17.56(Max Conc. mM)
Ethanol:3.0(Max Conc. mg/mL);5.27(Max Conc. mM)
form: A crystalline solid
pka: 3.66±0.10(Predicted)
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23961
Product name: ND-630
Purity: ≥98%
Packaging: 1mg
Price: $364
Updated: 2024/03/01

Cayman Chemical

Product number: 23961
Product name: ND-630
Purity: ≥98%
Packaging: 5mg
Price: $1181
Updated: 2024/03/01

AK Scientific

Product number: 9222DU
Product name: Firsocostat
Packaging: 5mg
Price: $1412
Updated: 2021/12/16

ChemScene

Product number: CS-6509
Product name: Firsocostat
Purity: 99.48%
Packaging: 10mg
Price: $450
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0005695
Product name: (R)-2-(1-(2-(2-METHOXYPHENYL)-2-((TETRAHYDRO-2H-PYRAN-4-YL)OXY)ETHYL)-5-METHYL-6-(OXAZOL-2-YL)-2,4-DIOXO-1,2-DIHYDROTHIENO[2,3-D]PYRIMIDIN-3(4H)-YL)-2-METHYLPROPANOIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $497.67
Updated: 2021/12/16

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NDI-010976 Chemical Properties,Usage,Production

Description

ND-630 is an allosteric inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits ACC1 and ACC2 activity (IC₅₀s = 2.1 and 6.1 nM, respectively, for the human enzymes). It is selective for ACC over 101 enzymes, receptors, growth factors, transporters, and ion channels up to a concentration of 10 μM. ND-630 prevents dimerization of ACC by interacting within the phosphopeptide-acceptor and dimerization site. It reduces fatty acid synthesis (EC₅₀s = 66 and 9 nM in 10% FBS and serum-free media, respectively) and increases fatty acid oxidation in HepG2 cells. ND-630 reduces hepatic steatosis in a rat model of diet-induced obesity and in Zucker diabetic rats. It also improves insulin secretion stimulated by glucose and reduces hemoglobin A1c levels by 0.9% in Zucker diabetic rats.

Uses

Firsocostat or ND-630 (CAS# 1434635-54-7) is an inhibitor of acetyl-coA carboxylase and may favorably affect the morbidity and mortality associated with obesity, diabetes, and fatty liver disease from reduced hepatic steatosis, improved insulin sensitivity, and modulation of dyslipidemia.

NDI-010976 Preparation Products And Raw materials

Raw materials

Preparation Products

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NDI-010976 Suppliers

China 88 United States 9 Global 97

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3466
Advantage: 58

Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd

Tel: 15317229551
Fax: QQ:3607245178
Email: 15151849396@163.com
Country: China
ProdList: 999
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14055
Advantage: 65

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9461
Advantage: 58

Syncozymes (Shanghai) Co.,Ltd.

Tel: 021-68187180-819 13681683526
Fax: 021-68187179
Email: lchen@syncozymes.com
Country: China
ProdList: 213
Advantage: 55

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9649
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4456
Advantage: 55

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View Lastest Price from NDI-010976 manufacturers

Honest Joy Holdings Limited

Product: NDI-010976 1434635-54-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.4%
Supply Ability: 100 tons
Release date: 2022-01-13

Career Henan Chemical Co

Product: NDI-010976 1434635-54-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kG
Release date: 2019-07-04

1434635-54-7, NDI-010976Related Search:

AC-262,356 ND-646 Remdesivir 2137975-08-5 CU-CPT-8m CU-CPT-9a GW-870086

NDI-010976

(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl)-2-methylpropanoicacid

ND-630

(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,2-dihydrothieno[2,3-d]pyrimidin-3(4H)-yl)-2-methylpropanoic acid

EOS-61252

GS0976

CPDB5078

(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,2-dihydrothieno[2,3-

GS0976,ND-630

1,4-Dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxothieno[2,3-d]pyrimidine-3(2H)-acetic acid

ND-630,NDI-010976

Firsocostat

Firsocostat(ND-630,GS-0976)

CS-2609

CS-2632

ND 630; ND630;GS-0976;GS 0976;GS0976;FIRSOCOSTAT

Firsocostat (GS-0976,NDI-010976,ND-630)

ND630;FIRSOCOSTAT

Firsocostat (ND-630

Thieno[2,3-d]pyrimidine-3(2H)-acetic acid, 1,4-dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxo-

ND-630（GS0976）

Firsocostat (GS-0976)

ND-630|||NDI-010976|||GS-0976

1434635-54-7

API