ChemicalBook > CAS DataBase List > NDI-010976

NDI-010976

Product Name
NDI-010976
CAS No.
1434635-54-7
Chemical Name
NDI-010976
Synonyms
ND-630;GS0976;CS-2609;CS-2632;CPDB5078;EOS-61252;NDI-010976;Firsocostat;GS0976,ND-630;ND-630（GS0976）
CBNumber
CB73133386
Molecular Formula
C28H31N3O8S
Formula Weight
569.63
MOL File
1434635-54-7.mol
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NDI-010976 Property

Boiling point:
779.0±70.0 °C(Predicted)
Density 
1.42±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:75.0(Max Conc. mg/mL);131.66(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);17.56(Max Conc. mM)
Ethanol:3.0(Max Conc. mg/mL);5.27(Max Conc. mM)
form 
A crystalline solid
pka
3.66±0.10(Predicted)
color 
White to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23961
Product name
ND-630
Purity
≥98%
Packaging
1mg
Price
$364
Updated
2024/03/01
Cayman Chemical
Product number
23961
Product name
ND-630
Purity
≥98%
Packaging
5mg
Price
$1181
Updated
2024/03/01
ChemScene
Product number
CS-6509
Product name
Firsocostat
Purity
99.48%
Packaging
5mg
Price
$270
Updated
2021/12/16
ChemScene
Product number
CS-6509
Product name
Firsocostat
Purity
99.48%
Packaging
10mg
Price
$450
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0005695
Product name
(R)-2-(1-(2-(2-METHOXYPHENYL)-2-((TETRAHYDRO-2H-PYRAN-4-YL)OXY)ETHYL)-5-METHYL-6-(OXAZOL-2-YL)-2,4-DIOXO-1,2-DIHYDROTHIENO[2,3-D]PYRIMIDIN-3(4H)-YL)-2-METHYLPROPANOIC ACID
Purity
95.00%
Packaging
5MG
Price
$497.67
Updated
2021/12/16
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NDI-010976 Chemical Properties,Usage,Production

Description

ND-630 is an allosteric inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits ACC1 and ACC2 activity (IC50s = 2.1 and 6.1 nM, respectively, for the human enzymes). It is selective for ACC over 101 enzymes, receptors, growth factors, transporters, and ion channels up to a concentration of 10 μM. ND-630 prevents dimerization of ACC by interacting within the phosphopeptide-acceptor and dimerization site. It reduces fatty acid synthesis (EC50s = 66 and 9 nM in 10% FBS and serum-free media, respectively) and increases fatty acid oxidation in HepG2 cells. ND-630 reduces hepatic steatosis in a rat model of diet-induced obesity and in Zucker diabetic rats. It also improves insulin secretion stimulated by glucose and reduces hemoglobin A1c levels by 0.9% in Zucker diabetic rats.

Uses

Firsocostat or ND-630 (CAS# 1434635-54-7) is an inhibitor of acetyl-coA carboxylase and may favorably affect the morbidity and mortality associated with obesity, diabetes, and fatty liver disease from reduced hepatic steatosis, improved insulin sensitivity, and modulation of dyslipidemia.

NDI-010976 Preparation Products And Raw materials

Raw materials

Preparation Products

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NDI-010976 Suppliers

China 88 United States 9 Global 97
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32063
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19553
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38463
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
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View Lastest Price from NDI-010976 manufacturers

Honest Joy Holdings Limited
Product
NDI-010976 1434635-54-7
Price
US $0.00/KG
Min. Order
1KG
Purity
97.4%
Supply Ability
100 tons
Release date
2022-01-13
Career Henan Chemical Co
Product
NDI-010976 1434635-54-7
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kG
Release date
2019-07-04

1434635-54-7, NDI-010976Related Search:

AC-262,356 ND-646 Remdesivir 2137975-08-5 CU-CPT-8m CU-CPT-9a GW-870086

  • NDI-010976
  • (R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl)-2-methylpropanoicacid
  • ND-630
  • (R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,2-dihydrothieno[2,3-d]pyrimidin-3(4H)-yl)-2-methylpropanoic acid
  • EOS-61252
  • GS0976
  • CPDB5078
  • (R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,2-dihydrothieno[2,3-
  • GS0976,ND-630
  • 1,4-Dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxothieno[2,3-d]pyrimidine-3(2H)-acetic acid
  • ND-630,NDI-010976
  • Firsocostat
  • Firsocostat(ND-630,GS-0976)
  • CS-2609
  • CS-2632
  • ND 630; ND630;GS-0976;GS 0976;GS0976;FIRSOCOSTAT
  • Firsocostat (GS-0976,NDI-010976,ND-630)
  • ND630;FIRSOCOSTAT
  • Firsocostat (ND-630
  • Thieno[2,3-d]pyrimidine-3(2H)-acetic acid, 1,4-dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxo-
  • ND-630（GS0976）
  • Firsocostat (GS-0976)
  • ND-630|||NDI-010976|||GS-0976
  • 1434635-54-7
  • API