BAY-876

ChemicalBook > CAS DataBase List > BAY-876

Product Name: BAY-876
CAS No.: 1799753-84-6
Chemical Name: BAY-876
Synonyms: BAY-876;CS-2442;BAY876;BAY 876;BAY-876 >=98% (HPLC);BAY-876, 10 mM in DMSO;N4-(1-(4-cyanobenzyl)-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-7-fluoroquinoline-2,4-dicarboxamide;N4-[1-[(4-cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-Quinolinedicarboxamide;2,4-Quinolinedicarboxamide, N4-[1-[(4-cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-;Inhibitor,metabolism,transporter,ovarian,BAY876,BAY 876,glycolytic,cancer,Glucose transporter,glucose,inhibit,BAY-876,orally,GLUT
CBNumber: CB73133472
Molecular Formula: C24H16F4N6O2
Formula Weight: 496.42
MOL File: 1799753-84-6.mol

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BAY-876 Property

Melting point:: >250oC (dec.)
Boiling point:: 632.3±55.0 °C(Predicted)
Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: powder
pka: 10.33±0.70(Predicted)
color: white to beige

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1774
Product name: BAY-876
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $191
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1774
Product name: BAY-876
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $760
Updated: 2023/06/20

Cayman Chemical

Product number: 19961
Product name: BAY-876
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 19961
Product name: BAY-876
Purity: ≥98%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 19961
Product name: BAY-876
Purity: ≥98%
Packaging: 10mg
Price: $283
Updated: 2024/03/01

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BAY-876 Chemical Properties,Usage,Production

Description

Uses

BAY-876 is a potent and selective inhibitor of glucose transporter 1 (Glut1) with IC50 values of 2, 10,800, 1,670, and 290 nM for Glut1, Glut2, Glut3, and Glut4, respectively, in CHO cells expressing human recombinant receptors.1 It shows low metabolic clearance and has high permeability in vitro. In vivo, BAY-876 displays low plasma clearance and high oral bioavailability in rats and dogs.

Biological Activity

Potent and selective GLUT1 inhibitor (IC50 = 2 nM). Displays selectivity for GLUT1 over GLUT2/3/4 (IC50 values are 10.8, 1.67 and 0.29 μM, respectively). Induces cell death in hypoxic conditions in vitro. Inhibits glucose uptake by Hela-MaTu cells. Cell permeable and orally bioavailable.

Biochem/physiol Actions

BAY-876 is a potent, highly selective, cell-permeable inhibitor of glucose transporter GLUT1. It had an IC50 value of 2 nM in vitro and inhibited glucose uptake by Hela-MaTu cells with an IC50 value of 3.2 nM. BAY-876 was at least 130-fold selective for GLUT1 relative to GLUT2, GLUT3, GLUT4 and a panel of 18 kinases and 68 proteins. For full characterization details, please visit the BAY-876 probe summary on the Structural Genomics Consortium (SGC) website.BAY-588 is the negative control for the active probe, BAY-876. BAY-588 is available from Sigma. To learn more about and purchase BAY-588, click here.To learn about other SGC chemical probes for protein targets, visit sigma.com/sgc

storage

Store at +4°C

BAY-876 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BAY-876 manufacturers

Career Henan Chemical Co

Product: BAY-876 1799753-84-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2019-12-26

1799753-84-6, BAY-876Related Search:

XMD16-5 GNE-3511 RAF709 Acebilustat

CS-2442

BAY876;BAY 876

N4-[1-[(4-cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-Quinolinedicarboxamide

BAY-876

N4-(1-(4-cyanobenzyl)-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-7-fluoroquinoline-2,4-dicarboxamide

BAY-876 >=98% (HPLC)

2,4-Quinolinedicarboxamide, N4-[1-[(4-cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-

Inhibitor,metabolism,transporter,ovarian,BAY876,BAY 876,glycolytic,cancer,Glucose transporter,glucose,inhibit,BAY-876,orally,GLUT

BAY-876, 10 mM in DMSO

1799753-84-6