KY 05009
- Product Name
- KY 05009
- CAS No.
- 1228280-29-2
- Chemical Name
- KY 05009
- Synonyms
- KY 05009;KY-05009 ，E2376;KY-05009 (KY05009;KY-05009 >=98% (HPLC);KY-05009, 10 mM in DMSO;TNIK Inhibitor, KY-05009;5-(4-methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide;4-Thiazolecarboxamide, 5-[(4-methylbenzoyl)amino]-2-(phenylamino)-;5-(4-methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide(WXC06259);KY-05009,plasma-cells,MAP4K,Apoptosis,TNIK,inhibit,anti-cancer,KY05009,Wnt,caspase-dependent,MAPK Kinase Kinase Kinase,anti-proliferative,IL-6,Inhibitor,smyeloma,aminothiazole,KY 05009
- CBNumber
- CB73146320
- Molecular Formula
- C18H16N4O2S
- Formula Weight
- 352.41
- MOL File
- 1228280-29-2.mol
KY 05009 Property
- storage temp.
- 2-8°C
- solubility
- DMSO:76.67(Max Conc. mg/mL);217.54(Max Conc. mM)
- form
- powder
- color
- light yellow to dark yellow
N-Bromosuccinimide Price
- Product number
- SML1506
- Product name
- KY-05009
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $131
- Updated
- 2025/07/31
- Product number
- SML1506
- Product name
- KY-05009
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $395
- Updated
- 2025/07/31
- Product number
- 5.33298
- Product name
- TNIK Inhibitor, KY-05009
- Packaging
- 10 mg
- Price
- $215
- Updated
- 2025/07/31
- Product number
- 29552
- Product name
- KY 05009
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 29552
- Product name
- KY 05009
- Packaging
- 25mg
- Price
- $442
- Updated
- 2024/03/01
KY 05009 Chemical Properties,Usage,Production
Uses
KY-05009 is an ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with a Ki of 100 nM. KY-05009 pharmacologically inhibits TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells. KY-05009 inhibits the protein expression of TNIK and transcriptional activity of Wnt target genes and induces apoptosis in cancer cells. KY-05009 exerts anti-cancer activity[1].
Biochem/physiol Actions
KY-05009 is a Traf2- and Nck-interacting kinase (TNIK) inhibitor that inhibits the epithelial-to-mesenchymal transition (EMT) in cancer cells.
IC 50
TNIK: 100 nM (Ki)
References
[1] Lee Y, et al. Synergistic inhibition effect of TNIK inhibitor KY-05009 and receptor tyrosine kinase inhibitor dovitinib on IL-6-induced proliferation and Wnt signaling pathway in human multiple myeloma cells. Oncotarget. 2017 Jun 20;8(25):41091-41101. DOI:10.18632/oncotarget.17056
KY 05009 Preparation Products And Raw materials
Raw materials
Preparation Products
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