N106
- Product Name
- N106
- CAS No.
- 862974-25-2
- Chemical Name
- N106
- Synonyms
- N106, 10 mM in DMSO;4-Methoxy-N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl-2-benzothiazolamine;2-Benzothiazolamine, 4-methoxy-N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-;N-(4-Methoxybenzo[d]thiazol-2-yl)-5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-amine
- CBNumber
- CB73146335
- Molecular Formula
- C17H14N4O3S
- Formula Weight
- 354.38
- MOL File
- 862974-25-2.mol
N106 Property
- Boiling point:
- 545.4±56.0 °C(Predicted)
- Density
- 1.390±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 20 mg/ml
- form
- A solid
- pka
- 1.03±0.10(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- N926030
- Product name
- N106
- Packaging
- 1mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- Axon2565
- Product name
- N106
- Purity
- 99%
- Packaging
- 25mg
- Price
- $368.5
- Updated
- 2021/12/16
- Product number
- 0326CK
- Product name
- N-(4-Methoxybenzo[d]thiazol-2-yl)-5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-amine
- Packaging
- 25mg
- Price
- $749
- Updated
- 2021/12/16
N106 Chemical Properties,Usage,Production
Uses
N106 is an activator of SUMO-activating enzyme, E1 ligase.
in vivo
In a murine model, the half-life of N106 is determined to be ~65.4min with a Cmax of ~2.24μM when the mice received 10mg/kg of N106 by intravenous injection. The oral bioavailability (F%) is 56% and 50%, and terminal elimination half-life (t1/2) is 19min[1].
In vivo, N106 (10 mg/kg) increases cardiac SERCA2A SUMOylation, and significantly improves ventricular function in mice with heart failure[1].
N106 Preparation Products And Raw materials
Raw materials
Preparation Products
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