SH5-07
- Product Name
- SH5-07
- CAS No.
- 1456632-41-9
- Chemical Name
- SH5-07
- Synonyms
- SH5-07;SH5-07 (SH-5-07);SH5-07, 10 mM in DMSO;Inhibitor,SH5-07,SH5 07,inhibit,STAT,SH507,SH-5-07;4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-N-hydroxybenzamide;Benzamide, 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-N-hydroxy-
- CBNumber
- CB73147594
- Molecular Formula
- C29H28F5N3O5S
- Formula Weight
- 625.61
- MOL File
- 1456632-41-9.mol
SH5-07 Property
- Density
- 1.437±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 50 mg/mL (79.92 mM);Water : < 0.1 mg/mL (insoluble)
- form
- Solid
- pka
- 9.03±0.10(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- S283000
- Product name
- SH5-07
- Packaging
- 2.5mg
- Price
- $580
- Updated
- 2021/12/16
- Product number
- CS-6232
- Product name
- SH5-07
- Purity
- >98.0%
- Packaging
- 1mg
- Price
- $84
- Updated
- 2021/12/16
- Product number
- CS-6232
- Product name
- SH5-07
- Purity
- >98.0%
- Packaging
- 5mg
- Price
- $252
- Updated
- 2021/12/16
- Product number
- CS-6232
- Product name
- SH5-07
- Purity
- >98.0%
- Packaging
- 10mg
- Price
- $420
- Updated
- 2021/12/16
- Product number
- CS-6232
- Product name
- SH5-07
- Purity
- >98.0%
- Packaging
- 50mg
- Price
- $1800
- Updated
- 2021/12/16
SH5-07 Chemical Properties,Usage,Production
Uses
SH5-?07 is a STAT3-inhibitor blocking the activation of signal transduction and subsequent activation of transcription 3 in chronic myeloid leukemia cell lines.
in vivo
Tail vein injection or oral gavage delivery of SH5-07 or SH4-54 inhibits growth of 90-150 mm3 established subcutaneous mouse xenografts of human glioma (U251MG) and breast (MDA-MB-231) tumors that harbor aberrantly-active Stat3, associated with decreased c-Myc, Mcl-1 and Cyclin D1 expression. No significant changes in body weights, blood cell counts, or the gross anatomy of organs, or obvious signs of toxicity are observed[1].
IC 50
STAT3: 3.9 μM (IC50)
SH5-07 Preparation Products And Raw materials
Raw materials
Preparation Products
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