2-Chloro-5-(difluoromethoxy)pyrimidine

Product Name: 2-Chloro-5-(difluoromethoxy)pyrimidine
CAS No.: 1192813-64-1
Chemical Name: 2-Chloro-5-(difluoromethoxy)pyrimidine
Synonyms: 2-Chloro-5-(difluoromethoxy)pyrimidine;Pyrimidine, 2-chloro-5-(difluoromethoxy)-;2-chloro-5-[(difluoromethyl)oxy]pyrimidine
CBNumber: CB73150785
Molecular Formula: C5H3ClF2N2O
Formula Weight: 180.54
MOL File: 1192813-64-1.mol

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2-Chloro-5-(difluoromethoxy)pyrimidine Property

Boiling point:: 260.1±30.0 °C(Predicted)
Density: 1.466±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -2.63±0.22(Predicted)
form: liquid
color: Clear, colourless

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific

Product number: PC56706
Product name: 2-Chloro-5-(difluoromethoxy)pyrimidine
Purity: 95%
Packaging: 500mg
Price: $192
Updated: 2021/12/16

Apolloscientific

Product number: PC56706
Product name: 2-Chloro-5-(difluoromethoxy)pyrimidine
Purity: 95%
Packaging: 250mg
Price: $114
Updated: 2021/12/16

Ambeed

Product number: A812296
Product name: 2-Chloro-5-(difluoromethoxy)pyrimidine
Purity: 95%
Packaging: 250mg
Price: $172
Updated: 2021/12/16

Ambeed

Product number: A812296
Product name: 2-Chloro-5-(difluoromethoxy)pyrimidine
Purity: 95%
Packaging: 100mg
Price: $100
Updated: 2021/12/16

Crysdot

Product number: CD11334854
Product name: 2-Chloro-5-(difluoromethoxy)pyrimidine
Purity: 97%
Packaging: 1g
Price: $236
Updated: 2021/12/16

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2-Chloro-5-(difluoromethoxy)pyrimidine Chemical Properties,Usage,Production

Synthesis

1895-39-2

4983-28-2

1192813-64-1

Step A: Synthesis of 2-chloro-5-(difluoromethoxy)pyrimidine 2-Chloropyrimidin-5-ol (1 g, 7.66 mmol) and sodium 2-chloro-2,2-difluoroacetate (3.50 g, 22.98 mmol) were dissolved in N,N-dimethylformamide (20 mL), water (0.2 mL) was added, and the reaction mixture was heated to 90 °C for 24 hours. After completion of the reaction, the solvent was removed by vacuum concentration. The crude product was purified by column chromatography (eluent: 5-30% ethyl acetate/hexane) to afford 2-chloro-5-(difluoromethoxy)pyrimidine (549 mg, 3.04 mmol, 39.7% yield) as a light yellow oil. Mass spectrometry (LC/MS) analysis showed retention time (R.T.) = 1.32 min; [M+H]+ = 181.14.

References

[1] Patent: US2009/270405, 2009, A1. Location in patent: Page/Page column 90
[2] Patent: WO2011/53292, 2011, A1. Location in patent: Page/Page column 149-150

2-Chloro-5-(difluoromethoxy)pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-5-(difluoromethoxy)pyrimidine Suppliers

China 62 India 1 United States 4 Global 67

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1192813-64-1, 2-Chloro-5-(difluoromethoxy)pyrimidineRelated Search:

2-Chloro-5-(difluoromethoxy)pyrimidine

Pyrimidine, 2-chloro-5-(difluoromethoxy)-

2-chloro-5-[(difluoromethyl)oxy]pyrimidine

1192813-64-1