ChemicalBook > CAS DataBase List > UNC-2371A

UNC-2371A

Product Name
UNC-2371A
CAS No.
1429882-07-4
Chemical Name
UNC-2371A
Synonyms
UNC2371;MRX-2843;UNC-2371A;UNC2371;MRX-2843;MRX-2843 (UNC2371);MRX-2843, 10 mM in DMSO;MRX-2843?(Synonyms: UNC2371;(1r,4r)-4-(2-(2-cyclopropylethylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol;trans-4-(2-((2-Cyclopropylethyl)amino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol;trans-4-[2-[(2-Cyclopropylethyl)amino]-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexanol
CBNumber
CB73168663
Molecular Formula
C29H40N6O
Formula Weight
488.67
MOL File
1429882-07-4.mol
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UNC-2371A Property

Melting point:
>137°C (dec.)
Boiling point:
697.3±65.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
pka
14.63±0.40(Predicted)
form 
Solid
color 
White to Pale Beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27923
Product name
MRX-2843
Packaging
1mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
27923
Product name
MRX-2843
Packaging
10mg
Price
$333
Updated
2024/03/01
Cayman Chemical
Product number
27923
Product name
MRX-2843
Packaging
5mg
Price
$179
Updated
2024/03/01
TRC
Product number
M750145
Product name
MRX-2843
Packaging
25mg
Price
$545
Updated
2021/12/16
ChemScene
Product number
CS-8117
Product name
MRX-2843
Purity
99.70%
Packaging
10mg
Price
$672
Updated
2021/12/16
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UNC-2371A Chemical Properties,Usage,Production

Description

MRX-2843 is an inhibitor of Mer and FMS-like tyrosine kinase 3 (FLT3; IC50s = 1.3 and 1 nM, respectively). It also inhibits Axl and Tyro3 (IC50s = 15 and 17 nM, respectively). MRX-2843 (10-300 nM) inhibits Mer phosphorylation in MOLM-14 and MV4-11 acute myeloid leukemia (AML) cells and reduces clonal expansion of Kasumi-1 AML cells (IC50 = 143.5 nM). In vivo, MRX-2843 increases survival in NOMO-1 and MOLM-14 AML mouse xenograft models when administered at doses of 65 and 50 mg/kg, respectively.

Uses

MRX-2843, is an orally available small-molecule inhibitor of both MERTK and FLT3.

in vivo

MRX-2843 is 78% orally bioavailable at a dose of 3 mg/kg with a Cmax of 1.3 μM and a t1/2 of 4.4 hours. In MOLM-14 parental xenografts, both quizartinib and MRX-2843 increase median survival compare with that of vehicle-treated mice (172.5 days versus 40 days and 121 days versus 36 days, respectively, P<0.001). In this model, quizartinib is more effective than MRX-2843 (P<0.005), although higher doses of MRX-2843 are not evaluated. In MOLM-14:D835Y xenografts, quizartinib prolongs survival compare with that of vehicle-treated mice, but the effect is minimal (median survival 45 days vs. 36 days, P<0.001). In MOLM-14:F691L xenografts, treatment with MRX-2843 prolongs survival by almost 2-fold in NSG and NSGS mice (median survival 87 vs. 44.5 days and 87 vs. 48 days, respectively, P<0.005). Increased survival is observed in response to treatment with MRX-2843 versus quizartinib, but the difference is only significant in NSG mice[1].

References

[1] WEIHE ZHANG. UNC2025, a Potent and Orally Bioavailable MER/FLT3 Dual Inhibitor[J]. Journal of Medicinal Chemistry, 2014, 57 16: 7031-7041. DOI: 10.1021/jm500749d
[2] KATHERINE A MINSON. The MERTK/FLT3 inhibitor MRX-2843 overcomes resistance-conferring FLT3 mutations in acute myeloid leukemia.[J]. JCI insight, 2016, 1 3: e85630. DOI: 10.1172/jci.insight.85630

UNC-2371A Preparation Products And Raw materials

Raw materials

Preparation Products

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UNC-2371A Suppliers

China 59 United States 4 Global 63
ChemCell Biomedicine Co.,Ltd.
Tel
020-13556033878 2965585218 13556033878
Fax
0086-0757-85406358
Email
chemcell@hotmail.com
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China
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369
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Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9637
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58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
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55
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
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9125
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Shanghai SuperLan Chemcial Technique Centre
Tel
0-2022843681 15618226720
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+86-21-51601218
Email
chaolaichem@foxmail.com
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China
ProdList
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Chuzhou KeMail Chemical Technology Co., Ltd
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0550-5196001 15000891977
Fax
0550-5196001
Email
wj520wjxby@126.com
Country
China
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1944
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Dezhou LonWel Pharmaceutical Technology Co., Ltd.
Tel
13761310616
Fax
QQ: 39324283
Email
39324283@qq.com
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China
ProdList
1637
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58
Nanjing SynTitan Pharmaceutical Co., Ltd.
Tel
025-57027686 17372956142
Fax
025-57027686
Email
li_lan@syntitan.com
Country
China
ProdList
9998
Advantage
58
Guangdong wengjiang Chemical Reagent Co., Ltd.
Tel
0751-2815688 13927872512
Fax
0751-8963795
Email
3007421951@qq.com
Country
China
ProdList
9939
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58
Finetech Industry Limited
Tel
+86-27-8746-5837 +8619945049750
Fax
86 27 87772287
Email
info@finetechnology-ind.com
Country
China
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9629
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1429882-07-4, UNC-2371ARelated Search:


  • (1r,4r)-4-(2-(2-cyclopropylethylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol
  • UNC-2371A
  • MRX-2843 (UNC2371)
  • MRX-2843
  • UNC2371
  • UNC2371;MRX-2843
  • Cyclohexanol, 4-[2-[(2-cyclopropylethyl)amino]-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-, trans-
  • MRX-2843?(Synonyms: UNC2371
  • UNC 2371,FLT3,Fms like tyrosine kinase 3,CD135,inhibit,MRX2843,Cluster of differentiation antigen 135,UNC-2371,Inhibitor,MRX-2843,MRX 2843
  • trans-4-(2-((2-Cyclopropylethyl)amino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol
  • MRX-2843, 10 mM in DMSO
  • trans-4-[2-[(2-Cyclopropylethyl)amino]-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexanol
  • (1r,4r)-4-(2-((2-cyclopropylethyl)amino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexan-1-ol
  • 1429882-07-4
  • C29H40N6O