UNC-2371A

Product Name: UNC-2371A
CAS No.: 1429882-07-4
Chemical Name: UNC-2371A
Synonyms: UNC2371;MRX-2843;UNC-2371A;UNC2371;MRX-2843;MRX-2843 (UNC2371);MRX-2843?(Synonyms: UNC2371;(1r,4r)-4-(2-(2-cyclopropylethylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol;Cyclohexanol, 4-[2-[(2-cyclopropylethyl)amino]-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-, trans-;UNC 2371,FLT3,Fms like tyrosine kinase 3,CD135,inhibit,MRX2843,Cluster of differentiation antigen 135,UNC-2371,Inhibitor,MRX-2843,MRX 2843
CBNumber: CB73168663
Molecular Formula: C29H40N6O
Formula Weight: 488.67
MOL File: 1429882-07-4.mol

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UNC-2371A Property

Melting point:: >137°C (dec.)
Boiling point:: 697.3±65.0 °C(Predicted)
Density: 1.31±0.1 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
pka: 14.63±0.40(Predicted)
form: Solid
color: White to Pale Beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27923
Product name: MRX-2843
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 27923
Product name: MRX-2843
Packaging: 10mg
Price: $333
Updated: 2024/03/01

Cayman Chemical

Product number: 27923
Product name: MRX-2843
Packaging: 5mg
Price: $179
Updated: 2024/03/01

TRC

Product number: M750145
Product name: MRX-2843
Packaging: 25mg
Price: $545
Updated: 2021/12/16

ChemScene

Product number: CS-8117
Product name: MRX-2843
Purity: 99.70%
Packaging: 10mg
Price: $672
Updated: 2021/12/16

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UNC-2371A Chemical Properties,Usage,Production

Description

MRX-2843 is an inhibitor of Mer and FMS-like tyrosine kinase 3 (FLT3; IC₅₀s = 1.3 and 1 nM, respectively). It also inhibits Axl and Tyro3 (IC₅₀s = 15 and 17 nM, respectively). MRX-2843 (10-300 nM) inhibits Mer phosphorylation in MOLM-14 and MV4-11 acute myeloid leukemia (AML) cells and reduces clonal expansion of Kasumi-1 AML cells (IC₅₀ = 143.5 nM). In vivo, MRX-2843 increases survival in NOMO-1 and MOLM-14 AML mouse xenograft models when administered at doses of 65 and 50 mg/kg, respectively.

Uses

MRX-2843, is an orally available small-molecule inhibitor of both MERTK and FLT3.

UNC-2371A Preparation Products And Raw materials

Raw materials

Preparation Products

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UNC-2371A Suppliers

China 36 United States 4 Global 40

ChemCell Biomedicine Co.,Ltd.

Tel: 020-13556033878 2965585218 13556033878
Fax: 0086-0757-85406358
Email: chemcell@hotmail.com
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
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Shanghai Chaolan Chemical Technology Center

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Fax: 21-5161 9052
Email: info@SuperLan-chem.com
Country: China
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Chuzhou KeMail Chemical Technology Co., Ltd

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Dezhou LonWel Pharmaceutical Technology Co., Ltd.

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Nanjing SynTitan Pharmaceutical Co., Ltd.

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Guangdong wengjiang Chemical Reagent Co., Ltd.

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Zhejiang J&C Biological Technology Co.,Limited

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TargetMol Chemicals Inc.

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Email: marketing@targetmol.com
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InvivoChem

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Fax: 708-557-7486
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1429882-07-4, UNC-2371ARelated Search:

(1r,4r)-4-(2-(2-cyclopropylethylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol

UNC-2371A

MRX-2843 (UNC2371)

MRX-2843

UNC2371

UNC2371;MRX-2843

Cyclohexanol, 4-[2-[(2-cyclopropylethyl)amino]-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-, trans-

MRX-2843?(Synonyms: UNC2371

UNC 2371,FLT3,Fms like tyrosine kinase 3,CD135,inhibit,MRX2843,Cluster of differentiation antigen 135,UNC-2371,Inhibitor,MRX-2843,MRX 2843

1429882-07-4

C29H40N6O