E6005

ChemicalBook > CAS DataBase List > E6005

Product Name: E6005
CAS No.: 947620-48-6
Chemical Name: E6005
Synonyms: E6005;CS-2517;RVT-501;lotamilast;E 6005;E-6005;RVT-501 E6005;E 6005: RVT-501;Lotamilast (RVT501;RVT501,Lotamilast,E 6005,RVT 501,E-6005,Inhibitor,Phosphodiesterase (PDE),inhibit;METHYL 4-((3-(6,7-DIMETHOXY-2-(METHYLAMINO)QUINAZOLIN-4-YL)PHENYL)CARBAMOYL)BENZOATE
CBNumber: CB73170286
Molecular Formula: C26H24N4O5
Formula Weight: 472.49
MOL File: 947620-48-6.mol

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E6005 Property

storage temp.: Store at -20°C
solubility: DMSO:25.0(Max Conc. mg/mL);52.9(Max Conc. mM)
form: A solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 30203
Product name: E6005
Packaging: 5mg
Price: $95
Updated: 2024/03/01

Cayman Chemical

Product number: 30203
Product name: E6005
Packaging: 25mg
Price: $384
Updated: 2024/03/01

Cayman Chemical

Product number: 30203
Product name: E6005
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 30203
Product name: E6005
Packaging: 10mg
Price: $172
Updated: 2024/03/01

TRC

Product number: R800003
Product name: RVT501
Packaging: 2.5mg
Price: $65
Updated: 2021/12/16

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E6005 Chemical Properties,Usage,Production

Description

E6005 is an inhibitor of phosphodiesterase 4 (PDE4; IC₅₀ = 2.8 nM). It is selective for PDE4 over PDE1, PDE2, PDE3, and PDE5 with only 46.1, 51.6, 69.4, and 57.4% inhibition, respectively, at 30 μM. It inhibits the production of various cytokines in isolated human lymphocytes and monocytes (IC₅₀s = 0.49-3.1 nM). Topical application of E6005 (0.003-0.3%) reduces ear thickness in a mouse model of oxazolone-induced skin inflammation, as well as reduces oxazolone-induced scratching in mice. It reduces the severity of skin lesions in a model of mite-induced atopic dermatitis. Topical application of E6005 (0.03%) also inhibits the production of leukotriene B₄ (LTB₄; ) in mouse skin, as well as reduces scratching and cutaneous nerve firing induced by the proteinase-activated receptor 2 (PAR2) agonist SLIGRL-NH₂ in mice.

Uses

RVT 501 is a potent and selective inhibitor of human phosphodiesterase 4 (PDE4).

E6005 Preparation Products And Raw materials

Raw materials

Preparation Products

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E6005 Suppliers

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947620-48-6, E6005Related Search:

E6005

RVT-501

lotamilast

E 6005: RVT-501

METHYL 4-((3-(6,7-DIMETHOXY-2-(METHYLAMINO)QUINAZOLIN-4-YL)PHENYL)CARBAMOYL)BENZOATE

RVT-501 E6005

methyl 4-[({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}amino)carbonyl]benzoate

CS-2517

E 6005;E-6005

Benzoic acid, 4-[[[3-[6,7-dimethoxy-2-(methylamino)-4-quinazolinyl]phenyl]amino]carbonyl]-, methyl ester

Lotamilast (RVT501

RVT501,Lotamilast,E 6005,RVT 501,E-6005,Inhibitor,Phosphodiesterase (PDE),inhibit

947620-48-6