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E6005

Product Name
E6005
CAS No.
947620-48-6
Chemical Name
E6005
Synonyms
E6005;CS-2517;RVT-501;lotamilast;E 6005;E-6005;RVT-501 E6005;E 6005: RVT-501;Lotamilast (RVT501;RVT501,Lotamilast,E 6005,RVT 501,E-6005,Inhibitor,Phosphodiesterase (PDE),inhibit;METHYL 4-((3-(6,7-DIMETHOXY-2-(METHYLAMINO)QUINAZOLIN-4-YL)PHENYL)CARBAMOYL)BENZOATE
CBNumber
CB73170286
Molecular Formula
C26H24N4O5
Formula Weight
472.49
MOL File
947620-48-6.mol
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E6005 Property

storage temp. 
Store at -20°C
solubility 
DMSO:25.0(Max Conc. mg/mL);52.9(Max Conc. mM)
form 
A solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

Cayman Chemical
Product number
30203
Product name
E6005
Packaging
5mg
Price
$95
Updated
2024/03/01
Cayman Chemical
Product number
30203
Product name
E6005
Packaging
25mg
Price
$384
Updated
2024/03/01
Cayman Chemical
Product number
30203
Product name
E6005
Packaging
1mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
30203
Product name
E6005
Packaging
10mg
Price
$172
Updated
2024/03/01
TRC
Product number
R800003
Product name
RVT501
Packaging
2.5mg
Price
$65
Updated
2021/12/16
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E6005 Chemical Properties,Usage,Production

Description

E6005 is an inhibitor of phosphodiesterase 4 (PDE4; IC50 = 2.8 nM). It is selective for PDE4 over PDE1, PDE2, PDE3, and PDE5 with only 46.1, 51.6, 69.4, and 57.4% inhibition, respectively, at 30 μM. It inhibits the production of various cytokines in isolated human lymphocytes and monocytes (IC50s = 0.49-3.1 nM). Topical application of E6005 (0.003-0.3%) reduces ear thickness in a mouse model of oxazolone-induced skin inflammation, as well as reduces oxazolone-induced scratching in mice. It reduces the severity of skin lesions in a model of mite-induced atopic dermatitis. Topical application of E6005 (0.03%) also inhibits the production of leukotriene B4 (LTB4; ) in mouse skin, as well as reduces scratching and cutaneous nerve firing induced by the proteinase-activated receptor 2 (PAR2) agonist SLIGRL-NH2 in mice.

Uses

RVT 501 is a potent and selective inhibitor of human phosphodiesterase 4 (PDE4).

E6005 Preparation Products And Raw materials

Raw materials

Preparation Products

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E6005 Suppliers

China 53 India 1 United States 9 Global 63

947620-48-6, E6005Related Search:


  • E6005
  • RVT-501
  • lotamilast
  • E 6005: RVT-501
  • METHYL 4-((3-(6,7-DIMETHOXY-2-(METHYLAMINO)QUINAZOLIN-4-YL)PHENYL)CARBAMOYL)BENZOATE
  • RVT-501 E6005
  • methyl 4-[({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}amino)carbonyl]benzoate
  • CS-2517
  • E 6005;E-6005
  • Benzoic acid, 4-[[[3-[6,7-dimethoxy-2-(methylamino)-4-quinazolinyl]phenyl]amino]carbonyl]-, methyl ester
  • Lotamilast (RVT501
  • RVT501,Lotamilast,E 6005,RVT 501,E-6005,Inhibitor,Phosphodiesterase (PDE),inhibit
  • 947620-48-6