3-AMINO-2-BROMO-BENZOIC ACID METHYL ESTER
- Product Name
- 3-AMINO-2-BROMO-BENZOIC ACID METHYL ESTER
- CAS No.
- 106896-48-4
- Chemical Name
- 3-AMINO-2-BROMO-BENZOIC ACID METHYL ESTER
- Synonyms
- Methyl 3-aMino-2-broMobenzoate;Methyl 3-aMino-2-broMobenzoate 95%;3-AMINO-2-BROMO-BENZOIC ACID METHYL ESTER;Benzoic acid, 3-amino-2-bromo-, methyl ester
- CBNumber
- CB7324121
- Molecular Formula
- C8H8BrNO2
- Formula Weight
- 230.06
- MOL File
- 106896-48-4.mol
3-AMINO-2-BROMO-BENZOIC ACID METHYL ESTER Property
- Boiling point:
- 314.1±22.0 °C(Predicted)
- Density
- 1.583 g/mL at 25 °C
- refractive index
- n20/D1.601
- Flash point:
- >110℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 1.39±0.10(Predicted)
- form
- liquid
- color
- Clear, bright orange/amber
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26
- RIDADR
- 2810
- WGK Germany
- 3
- HazardClass
- 6.1
- PackingGroup
- Ⅲ
- HS Code
- 2922498590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 737275
- Product name
- Methyl 3-amino-2-bromobenzoate
- Purity
- 95%
- Packaging
- 500mg
- Price
- $109
- Updated
- 2023/01/07
- Product number
- M331298
- Product name
- Methyl 3-amino-2-bromobenzoate
- Packaging
- 100mg
- Price
- $40
- Updated
- 2021/12/16
- Product number
- M331298
- Product name
- Methyl 3-amino-2-bromobenzoate
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- M331298
- Product name
- Methyl 3-amino-2-bromobenzoate
- Packaging
- 1g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- OR301136
- Product name
- Methyl 3-amino-2-bromobenzoate
- Packaging
- 1g
- Price
- $92
- Updated
- 2021/12/16
3-AMINO-2-BROMO-BENZOIC ACID METHYL ESTER Chemical Properties,Usage,Production
Uses
Methyl 3-Amino-2-bromobenzoate is used in preparation of Carbazole-based compounds and its application as IDO inhibitor.
Synthesis
5337-09-7
106896-48-4
Methyl 2-bromo-3-nitrobenzoate (12.9 g, 49.5 mmol) was used as feedstock and prepared according to the method described by Webber ES et al. (Patent Application No. WO 01/16136 A2). The feedstock was refluxed with SnCl2 (42 g, 223 mmol) in a mixed solution of methanol (225 mL, 0.2 M) and H2O (5.3 g, 243 mmol) for 2 hours. After completion of the reaction, it was cooled to room temperature and diatomaceous earth (20 g) and dichloromethane (1 L) were added, followed by the slow addition of 3 N aqueous sodium hydroxide solution (150 mL) under vigorous stirring. The reaction mixture was filtered and the organic phase was washed with saturated aqueous sodium chloride solution. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to remove all volatiles to afford the intermediate methyl 3-amino-2-bromobenzoate (11.4 g) in 98% yield.1H-NMR (d6-DMSO) δ: 7.12 (dd, 1H, J = 8.1, 7.5 Hz), 6.93 (dd, 1H, J = 8.1, 1.6 Hz), 6.80 ( dd, 1H, J = 7.4, 1.6 Hz), 5.57 (s, 2H), 3.81 (s, 3H).
References
[1] Patent: WO2004/63198, 2004, A1. Location in patent: Page 77
[2] Tetrahedron, 2010, vol. 66, # 29, p. 5402 - 5406
[3] Tetrahedron, 2000, vol. 56, # 2, p. 165 - 173
[4] Journal of Organic Chemistry, 1988, vol. 53, # 6, p. 1170 - 1176
[5] Patent: EP950657, 1999, A2
3-AMINO-2-BROMO-BENZOIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-AMINO-2-BROMO-BENZOIC ACID METHYL ESTER manufacturers
- Product
- 3-AMINO-2-BROMO-BENZOIC ACID METHYL ESTER 106896-48-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-20