METHYL 2-BROMO-3-NITROBENZOATE
- Product Name
- METHYL 2-BROMO-3-NITROBENZOATE
- CAS No.
- 5337-09-7
- Chemical Name
- METHYL 2-BROMO-3-NITROBENZOATE
- Synonyms
- METHYL 2-BROMO-3-NITROBENZOATE;2-bromo-3-nitro-benzoicacimethylester;3-Nitro-2-bromobenzoic acid methyl ester;2-BROMO-3-NITRO-BENZOIC ACID METHYL ESTER;Benzoic acid, 2-bromo-3-nitro-, methyl ester
- CBNumber
- CB1414332
- Molecular Formula
- C8H6BrNO4
- Formula Weight
- 260.04
- MOL File
- 5337-09-7.mol
METHYL 2-BROMO-3-NITROBENZOATE Property
- Melting point:
- 77 °C(Solv: methanol (67-56-1))
- Boiling point:
- 300.0±20.0 °C(Predicted)
- Density
- 1.673±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform, DCM, Ethyl Acetate
- form
- Solid
- color
- Off-White
- EPA Substance Registry System
- Benzoic acid, 2-bromo-3-nitro-, methyl ester (5337-09-7)
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HS Code
- 2916310090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B687290
- Product name
- 2-Bromo-3-nitrobenzoicAcidMethylEster
- Packaging
- 50mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- OR400515
- Product name
- Methyl2-bromo-3-nitrobenzoate
- Packaging
- 5g
- Price
- $156
- Updated
- 2021/12/16
- Product number
- 4654-9-12
- Product name
- 2-Bromo-3-nitrobenzoic acid methyl ester
- Purity
- 95%
- Packaging
- 5G
- Price
- $172
- Updated
- 2021/12/16
- Product number
- V6459
- Product name
- Methyl2-bromo-3-nitrobenzoate
- Packaging
- 5g
- Price
- $234
- Updated
- 2021/12/16
- Product number
- OR400515
- Product name
- Methyl2-bromo-3-nitrobenzoate
- Packaging
- 1g
- Price
- $51
- Updated
- 2021/12/16
METHYL 2-BROMO-3-NITROBENZOATE Chemical Properties,Usage,Production
Uses
2-Bromo-3-nitrobenzoic Acid Methyl Ester is an halogenated benzoic acid and an intermediate in the synthesis of anti-inflammatory drug Balsalazide (B116300).
Synthesis
67-56-1
573-54-6
5337-09-7
General procedure for the synthesis of methyl 2-bromo-3-nitrobenzoate from methanol and 2-bromo-3-nitrobenzoic acid: Example 4: 100 g (406 mmol) of 2-bromo-3-nitrobenzoic acid and 22 g (609 mmol) of concentrated hydrochloric acid were added to a reactor followed by 1 liter of methanol. The reaction mixture was heated under reflux conditions for 24 hours. After completion of the reaction, it was cooled to room temperature and the precipitated solid product was collected by filtration. The solid was washed sequentially with deionized water and ethanol and then dried. Finally, the dried product was purified by recrystallization with ethanol. Methyl 2-bromo-3-nitrobenzoate 94.6 g (363 mmol) was obtained in 89.5% yield of the theoretical value.
References
[1] Patent: US2015/148550, 2015, A1. Location in patent: Paragraph 0167; 0168; 0169; 0170; 0171; 0172
[2] Tetrahedron, 2000, vol. 56, # 2, p. 165 - 173
[3] Patent: US9337430, 2016, B2. Location in patent: Page/Page column 117
[4] Bioorganic and Medicinal Chemistry Letters, 1997, vol. 7, # 11, p. 1399 - 1402
[5] Molecular Pharmacology, 2013, vol. 84, # 5, p. 726 - 735
METHYL 2-BROMO-3-NITROBENZOATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHYL 2-BROMO-3-NITROBENZOATE manufacturers
- Product
- METHYL 2-BROMO-3-NITROBENZOATE 5337-09-7
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-10