1-Bromo-2-nitrobenzene Property

Melting point:

40-42 °C (lit.)

Boiling point:

261 °C (lit.)

Density 

1.7 g/cm3 (20℃)

refractive index 

1.6060 (estimate)

Flash point:

>230 °F

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

powder to crystal

color 

Light yellow to Amber to Dark green

Water Solubility 

insoluble

BRN 

2044109

Stability:

Stable. Combustible. Incompatible with strong bases, strong oxidizing agents.

CAS DataBase Reference

577-19-5(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, 1-bromo-2-nitro-(577-19-5)

EPA Substance Registry System

o-Bromonitrobenzene (577-19-5)

Safety

Hazard Codes 

Xn,Xi

Risk Statements 

20/21/22-36/37/38-22

Safety Statements 

36/37-36/37/39-26-22

RIDADR 

UN 3459 6.1/PG 3

WGK Germany 

3

RTECS 

CY9040450

Hazard Note 

Irritant

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

29049085

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

1-Bromo-2-nitrobenzene Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

1-Bromo-2-nitrobenzene is used in organic synthesis. It also can react with 2-methylamino-benzoic acid to get N-methyl-N-(2-nitro-phenyl)-anthranilic acid. And it is also used in the preparation of 4-methoxy-2?-nitrodiphenyl ether, 1-methoxy-3,5-bis-(2-nitro-phenoxy)benzene.

Uses

1-Bromo-2-nitrobenzene may be used in the preparation of:

• 4-methoxy-2′-nitrodiphenyl ether
• 1-methoxy-3,5-bis-(2-nitro-phenoxy)benzene
• 5-hydroxy-3-methoxy-2′-nitrodiphenyl ether

General Description

1-Bromo-2-nitrobenzene undergoes palladium[0]-mediated Ullmann cross-coupling reaction with a range of β-halo-enals, -enones or -esters to afford the corresponding β-aryl derivatives. Palladium[0]-mediated Ullmann cross-coupling reaction of 1-bromo-2-nitrobenzene with β-bromo-α,β-unsaturated aldehydes is reported.

Purification Methods

Crystallise it twice from pet ether, using charcoal before the first crystallisation. [Beilstein 5 III 618, 5 IV 728.]