2,4-Difluorotoluene
- Product Name
- 2,4-Difluorotoluene
- CAS No.
- 452-76-6
- Chemical Name
- 2,4-Difluorotoluene
- Synonyms
- 2,4-Difluorobenzyl;difluorotoluene;2,4-DIFLUOROTOLUNE;2,4-DIFLUOROTOLUINE;2,4-DIFLUOROTOLUENE;2,4-Difluorotoluene99%;2,4-Difluorotoluene 99%;2,4-Difluorotoluene, 98+%;2.4-Difluoro methyl benzene;1-Methyl-2,4-difluorobenzene
- CBNumber
- CB7329212
- Molecular Formula
- C7H6F2
- Formula Weight
- 128.12
- MOL File
- 452-76-6.mol
2,4-Difluorotoluene Property
- Melting point:
- -35 °C
- Boiling point:
- 113-117 °C (lit.)
- Density
- 1.12 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.449(lit.)
- Flash point:
- 59 °F
- storage temp.
- Sealed in dry,2-8°C
- form
- Liquid
- Specific Gravity
- 1.120
- color
- Clear colorless
- BRN
- 1931681
- InChI
- InChI=1S/C7H6F2/c1-5-2-3-6(8)4-7(5)9/h2-4H,1H3
- InChIKey
- MPXDAIBTYWGBSL-UHFFFAOYSA-N
- SMILES
- C1(C)=CC=C(F)C=C1F
- CAS DataBase Reference
- 452-76-6(CAS DataBase Reference)
- NIST Chemistry Reference
- 2,4-Difluorotoluene(452-76-6)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D2351
- Product name
- 2,4-Difluorotoluene
- Packaging
- 10g
- Price
- $69
- Updated
- 2025/07/31
- Product number
- D452568
- Product name
- 2,4-Difluorotoluene
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- D452568
- Product name
- 2,4-Difluorotoluene
- Packaging
- 500mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- D452568
- Product name
- 2,4-Difluorotoluene
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- PC2930
- Product name
- 2,4-Difluorotoluene
- Purity
- 98%
- Packaging
- 25g
- Price
- $67
- Updated
- 2021/12/16
2,4-Difluorotoluene Chemical Properties,Usage,Production
Chemical Properties
colorless to light yellow liqui
Uses
2,4-Difluorotoluene was used in the synthesis of new hydrophobic isosteres of pyrimidines and purine nucleosides.
General Description
2,4-Difluorotoluene was synthesized as a nucleotide analog and was incorporated into DNA and undergoes replication by DNA polymerase enzymes.
Synthesis
108-88-3
352-32-9
95-52-3
352-70-5
452-76-6
452-67-5
2927-34-6
The general procedure for the synthesis of p-fluorotoluene, 2-fluorotoluene, 3-fluorotoluene, 2,4-difluorotoluene, 2,5-difluorotoluene, and 1,2-difluoro-4-methylbenzene from toluene is as follows: to a glass reactor fitted with a PTFE-lined magnetic stirring bar attached to a gas scrubbing flask were added toluene derivative (0.95-1.14 mmol), acetonitrile (1-2.5 mL/mmol of toluene derivative), and boron trifluoride ethyl ether complex (1.3-1.6 mmol/mmol of toluene derivative). mmol toluene derivative), acetonitrile (1-2.5 mL/mmol toluene derivative) and boron trifluoride ethyl ether complex (1.3-1.6 mmol/mmol toluene derivative). The reaction mixture was stirred at -25 °C for 10-15 min, followed by the addition of xenon difluoride (1.2-1.3 mmol/mmol toluene derivative) in batches. The reaction system was slowly warmed to 22 °C over 1 h and stirring was continued for 40-60 min. Upon completion of the reaction, hexafluorobenzene was added as an internal standard and samples were taken for 19F NMR analysis (Method B). The reaction mixture was quenched with saturated aqueous sodium bicarbonate and extracted with dichloromethane (1-2 mL). The combined organic phases were dried with anhydrous magnesium sulfate and subsequently analyzed by 19F NMR and GC/MS (Procedure C). The major products are listed in the table and others are shown below (GC/MS data).
References
[1] Russian Journal of Organic Chemistry, 2016, vol. 52, # 10, p. 1400 - 1407
[2] Zh. Org. Khim., 2016, vol. 52, # 10, p. 1412 - 1419,8
2,4-Difluorotoluene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-Difluorotoluene manufacturers
- Product
- 2,4-Difluorotoluene 452-76-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 50mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-08
- Product
- 2,4-Difluorotoluene 452-76-6
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 98%MIN
- Supply Ability
- ASK
- Release date
- 2019-12-25