ChemicalBook > CAS DataBase List > 5-Methoxy-2-nitrobenzaldehyde

5-Methoxy-2-nitrobenzaldehyde

Product Name
5-Methoxy-2-nitrobenzaldehyde
CAS No.
20357-24-8
Chemical Name
5-Methoxy-2-nitrobenzaldehyde
Synonyms
m-Anisaldehyde, 6-nitro-;2-NITRO-5-METHOXYBENZALDEHYDE;5-METHOXY-2-NITROBENZALDEHYDE;Benzaldehyde, 5-methoxy-2-nitro-;N-(3-bromo-7-fluoro-9H-fluoren-2-yl)acetamide;5-Methoxy-2-nitrobenzaldehyde ISO 9001：2015 REACH;2-Formyl-4-methoxynitrobenzene, 3-Formyl-4-nitroanisole
CBNumber
CB7335323
Molecular Formula
C8H7NO4
Formula Weight
181.15
MOL File
20357-24-8.mol
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5-Methoxy-2-nitrobenzaldehyde Property

Melting point:
83 °C
Boiling point:
354.7±27.0 °C(Predicted)
Density 
1.322±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
crystalline solid
color 
Yellow
InChI
InChI=1S/C8H7NO4/c1-13-7-2-3-8(9(11)12)6(4-7)5-10/h2-5H,1H3
InChIKey
BNTDDWPHSMILHQ-UHFFFAOYSA-N
SMILES
C(=O)C1=CC(OC)=CC=C1[N+]([O-])=O
CAS DataBase Reference
20357-24-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
HS Code 
2912490090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M3593
Product name
5-Methoxy-2-nitrobenzaldehyde
Purity
min. 98.0 %
Packaging
1G
Price
$45
Updated
2025/07/31
TCI Chemical
Product number
M3593
Product name
5-Methoxy-2-nitrobenzaldehyde
Purity
min. 98.0 %
Packaging
5G
Price
$135
Updated
2025/07/31
TRC
Product number
M327058
Product name
5-Methoxy-2-nitrobenzaldehyde
Packaging
1g
Price
$70
Updated
2021/12/16
Apolloscientific
Product number
OR14772
Product name
5-Methoxy-2-nitrobenzaldehyde
Purity
98%
Packaging
1g
Price
$22
Updated
2021/12/16
SynQuest Laboratories
Product number
4654-1-W5
Product name
5-Methoxy-2-nitrobenzaldehyde
Packaging
1g
Price
$24
Updated
2021/12/16
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5-Methoxy-2-nitrobenzaldehyde Chemical Properties,Usage,Production

Uses

5-Methoxy-2-nitrobenzaldehyde is a starting material used to synthesize a novel class of cis-locked combretastatins named combretabenzodiazepines which shows cytotoxic and antitubulin activity.

Synthesis

42454-06-8

74-88-4

20357-24-8

Step 1. Synthesis of 5-methoxy-2-nitrobenzaldehyde: 5-hydroxy-2-nitrobenzaldehyde (1 eq.), iodomethane (1.1 eq.) and potassium carbonate (1 eq.) were dissolved in DMF at room temperature and the reaction was stirred for 16 hours. Upon completion of the reaction, the reaction mixture was concentrated and subsequently partitioned between ethyl acetate and water. The organic layer was washed with brine, dried over anhydrous sodium sulfate and concentrated to give 5-methoxy-2-nitrobenzaldehyde in quantitative yield. Mass spectrometry analysis showed the molecular ion peak [M+H]+ = 182.

References

[1] Patent: US2005/85482, 2005, A1. Location in patent: Page/Page column 13; 17
[2] Patent: WO2010/51031, 2010, A1. Location in patent: Page/Page column 45
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 4, p. 1678 - 1681
[4] Patent: CN107522766, 2017, A. Location in patent: Paragraph 0136; 0137; 0138
[5] Chemical Communications, 2011, vol. 47, # 42, p. 11683 - 11685

5-Methoxy-2-nitrobenzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-Methoxy-2-nitrobenzaldehyde manufacturers

Henan Fengda Chemical Co., Ltd
Product
5-Methoxy-2-nitrobenzaldehyde 20357-24-8
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-26
Shaanxi Dideu Medichem Co. Ltd
Product
5-Methoxy-2-nitrobenzaldehyde 20357-24-8
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
100 tons
Release date
2020-01-10
Career Henan Chemical Co
Product
5-Methoxy-2-nitrobenzaldehyde 20357-24-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-12

20357-24-8, 5-Methoxy-2-nitrobenzaldehydeRelated Search:

3,5-Dimethoxybenzaldehyde 2,6-Dimethoxybenzaldehyde 4-Nitrobenzaldehyde p-Anisaldehyde 2-Bromo-5-methoxybenzaldehyde Veratraldehyde (Trifluoromethoxy)benzene 3-Methoxybenzaldehyde o-Anisaldehyde 4-Nitrobenzoic acid 3-(METHOXYMETHOXY)BENZALDEHYDE 5-METHOXYTHIOPHENE-2-CARBOXYLIC ACID 5-METHOXY-2-METHYL-BENZOIC ACID METHYL ESTER 5-Methoxy-2-(trifluoroMethyl)benzaldehyde Nitrobenzene ETHYL 4,5-DIMETHOXY-2-NITROBENZOATE 6-Nitroveratraldehyde Methyl 2-nitro-3,4,5-trimethoxybenzoate

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  • m-Anisaldehyde, 6-nitro-
  • N-(3-bromo-7-fluoro-9H-fluoren-2-yl)acetamide
  • 5-Methoxy-2-nitrobenzaldehyde ISO 9001：2015 REACH
  • 20357-24-8