ChemicalBook > CAS DataBase List > 3-FLUORO-4-HYDROXYPHENYLACETIC ACID

3-FLUORO-4-HYDROXYPHENYLACETIC ACID

Product Name: 3-FLUORO-4-HYDROXYPHENYLACETIC ACID
CAS No.: 458-09-3
Chemical Name: 3-FLUORO-4-HYDROXYPHENYLACETIC ACID
Synonyms: 4-(Carboxymethyl)-2-fluorophenol;3-Fluoro-4-HydroxyphenylaceticAci;3-FLUORO-4-HYDROXYPHENYLACETIC ACID;3-Fluoro-4-hydroxybenzeneacetic acid;Benzeneacetic acid, 3-fluoro-4-hydroxy-;3-Fluoro-4-hydroxyphenylacetic acid,98%;2-(3-fluoro-4-hydroxyphenyl)acetic acid;4-(Carboxymethyl)-2-fluorophenol, (3-Fluoro-4-hydroxyphenyl)acetic acid
CBNumber: CB7335893
Molecular Formula: C8H7FO3
Formula Weight: 170.14
MOL File: 458-09-3.mol

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3-FLUORO-4-HYDROXYPHENYLACETIC ACID Property

Melting point:: 132-134 °C (lit.)
Boiling point:: 320.3±27.0 °C(Predicted)
Density: 1.423±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 4.30±0.10(Predicted)
form: Crystalline Powder
color: White to beige
CAS DataBase Reference: 458-09-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29182900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 224510
Product name: 3-Fluoro-4-hydroxyphenylacetic acid
Purity: 98%
Packaging: 1g
Price: $71.2
Updated: 2023/01/07

TRC

Product number: F596063
Product name: 3-Fluoro-4-hydroxyphenylacetic acid
Packaging: 500mg
Price: $70
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2629-3-14
Product name: 3-Fluoro-4-hydroxyphenylacetic acid
Purity: 98%
Packaging: 1g
Price: $25
Updated: 2021/12/16

Matrix Scientific

Product number: 002538
Product name: 3-Fluoro-4-hydroxyphenylacetic acid
Purity: 98%
Packaging: 1g
Price: $25
Updated: 2021/12/16

Apolloscientific

Product number: PC5039
Product name: 3-Fluoro-4-hydroxyphenylacetic acid
Packaging: 1g
Price: $29
Updated: 2021/12/16

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3-FLUORO-4-HYDROXYPHENYLACETIC ACID Chemical Properties,Usage,Production

Chemical Properties

White to beige crystalline powder

Synthesis

452-14-2

458-09-3

General procedure for the synthesis of 3-fluoro-4-hydroxyphenylacetic acid from 3-fluoro-4-methoxyphenylacetic acid: Aluminum chloride (42.8 g, 0.32 mol) was slowly added to 500 mL of toluene solution containing 3-fluoro-4-methoxyphenylacetic acid (45 g, 0.245 mol), and the temperature of the reaction was controlled to be no more than 25 °C. Subsequently, the reaction mixture was heated to reflux for 5 hours. Upon completion of the reaction, 260 mL of 10% hydrochloric acid was added to the cooled solution. The precipitate was collected by filtration and the filtrate was extracted twice with 75 mL of 1,2-dichloroethane. The organic extracts were combined and washed sequentially with 5% sodium hydroxide solution and water. The alkaline washings were combined with the previously collected precipitate and filtered through activated carbon after adjusting the pH to 12 with 5% sodium hydroxide solution. The filtrate was acidified with 50% sulfuric acid and the resulting oil was extracted with ether. The organic phase was dried and the solvent was evaporated to give 3-fluoro-4-hydroxyphenylacetic acid in a yield of 25 g (62% yield). The melting point of the product was 109-111 °C. Mass spectrum (ESI) m/z (relative abundance): 193.0 [M + Na]+.

Purification Methods

Crystallise the acid from water. [Beilstein 10 III 440.]

References

[1] Collection of Czechoslovak Chemical Communications, 1990, vol. 55, # 1, p. 296 - 306
[2] European Journal of Medicinal Chemistry, 2014, vol. 87, p. 508 - 518
[3] Chemische Berichte, 1952, vol. 85, p. 577,580
[4] DRP/DRBP Org.Chem.,

3-FLUORO-4-HYDROXYPHENYLACETIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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3-FLUORO-4-HYDROXYPHENYLACETIC ACID Suppliers

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View Lastest Price from 3-FLUORO-4-HYDROXYPHENYLACETIC ACID manufacturers

Honest Joy Holdings Limited

Product: 3-Fluoro-4-hydroxyphenylacetic acid 458-09-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.1%
Supply Ability: 100 tons
Release date: 2022-02-21

Career Henan Chemical Co

Product: 3-FLUORO-4-HYDROXYPHENYLACETIC ACID 458-09-3
Price: US $9.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg -1000kg
Release date: 2020-01-03

458-09-3, 3-FLUORO-4-HYDROXYPHENYLACETIC ACIDRelated Search:

3'-Fluoro-4'-hydroxyacetophenone 3-FLUORO-4-(TRIFLUOROMETHOXY)PHENYLACETIC ACID 2,3-DIFLUORO-4-METHOXYPHENYLACETIC ACID 3,5-DIFLUORO-4-METHOXYPHENYLACETIC ACID 3-FLUORO-4-HYDROXYPHENYLACETIC ACID 3-FLUORO-4-METHOXYPHENYLACETIC ACID 4-fluoro-à-hydroxyphenylacetic acid 2-Fluoro-4-hydroxyphenylacetic acid ETHYL 3-FLUORO-4-METHOXYBENZOYLFORMATE AMINO-(3-FLUORO-4-METHOXY-PHENYL)-ACETIC ACID Ethyl Difluoro-(3-fluoro-4-methoxyphenyl)acetate 2-Fluoro-5-hydroxyphenylacetic acid 4-Fluoro-3-hydroxyphenylacetic acid (2S)-2-AMINO-2-[3-FLUORO-4-(PHENYLMETHOXY)PHENYL]PROPANOIC ACID [3-(chlorosulfonyl)-5-fluoro-4-methoxyphenyl]acetic acid (2S)-2-AMINO-2-(3,5-DIFLUORO-4-METHOXYPHENYL)PROPANOIC ACID (2S)-2-AMINO-2-(3-FLUORO-4-[(4-NITROPHENYL)METHOXY]PHENYL)PROPANOIC ACID (2R)-2-AMINO-2-(3,5-DIFLUORO-4-METHOXYPHENYL)PROPANOIC ACID

3-FLUORO-4-HYDROXYPHENYLACETIC ACID

4-(Carboxymethyl)-2-fluorophenol, (3-Fluoro-4-hydroxyphenyl)acetic acid

4-(Carboxymethyl)-2-fluorophenol

2-(3-fluoro-4-hydroxyphenyl)acetic acid

3-Fluoro-4-hydroxybenzeneacetic acid

3-Fluoro-4-hydroxyphenylacetic acid,98%

Benzeneacetic acid, 3-fluoro-4-hydroxy-

3-Fluoro-4-HydroxyphenylaceticAci

458-09-3

FC6H3OHCH2CO2H

Organic Building Blocks

Building Blocks

Carboxylic Acids

Carbonyl Compounds

Fluorine series

Carbonyl Compounds

Carboxylic Acids

Aromatic Phenylacetic Acids and Derivatives