3-FLUORO-4-HYDROXYPHENYLACETIC ACID
- Product Name
- 3-FLUORO-4-HYDROXYPHENYLACETIC ACID
- CAS No.
- 458-09-3
- Chemical Name
- 3-FLUORO-4-HYDROXYPHENYLACETIC ACID
- Synonyms
- 4-(Carboxymethyl)-2-fluorophenol;3-Fluoro-4-HydroxyphenylaceticAci;3-FLUORO-4-HYDROXYPHENYLACETIC ACID;3-Fluoro-4-hydroxybenzeneacetic acid;Benzeneacetic acid, 3-fluoro-4-hydroxy-;3-Fluoro-4-hydroxyphenylacetic acid,98%;2-(3-fluoro-4-hydroxyphenyl)acetic acid;4-(Carboxymethyl)-2-fluorophenol, (3-Fluoro-4-hydroxyphenyl)acetic acid
- CBNumber
- CB7335893
- Molecular Formula
- C8H7FO3
- Formula Weight
- 170.14
- MOL File
- 458-09-3.mol
3-FLUORO-4-HYDROXYPHENYLACETIC ACID Property
- Melting point:
- 132-134 °C (lit.)
- Boiling point:
- 320.3±27.0 °C(Predicted)
- Density
- 1.423±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.30±0.10(Predicted)
- form
- Crystalline Powder
- color
- White to beige
- CAS DataBase Reference
- 458-09-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 224510
- Product name
- 3-Fluoro-4-hydroxyphenylacetic acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $71.2
- Updated
- 2023/01/07
- Product number
- F596063
- Product name
- 3-Fluoro-4-hydroxyphenylacetic acid
- Packaging
- 500mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 2629-3-14
- Product name
- 3-Fluoro-4-hydroxyphenylacetic acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $25
- Updated
- 2021/12/16
- Product number
- 002538
- Product name
- 3-Fluoro-4-hydroxyphenylacetic acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $25
- Updated
- 2021/12/16
- Product number
- PC5039
- Product name
- 3-Fluoro-4-hydroxyphenylacetic acid
- Packaging
- 1g
- Price
- $29
- Updated
- 2021/12/16
3-FLUORO-4-HYDROXYPHENYLACETIC ACID Chemical Properties,Usage,Production
Chemical Properties
White to beige crystalline powder
Synthesis
452-14-2
458-09-3
General procedure for the synthesis of 3-fluoro-4-hydroxyphenylacetic acid from 3-fluoro-4-methoxyphenylacetic acid: Aluminum chloride (42.8 g, 0.32 mol) was slowly added to 500 mL of toluene solution containing 3-fluoro-4-methoxyphenylacetic acid (45 g, 0.245 mol), and the temperature of the reaction was controlled to be no more than 25 °C. Subsequently, the reaction mixture was heated to reflux for 5 hours. Upon completion of the reaction, 260 mL of 10% hydrochloric acid was added to the cooled solution. The precipitate was collected by filtration and the filtrate was extracted twice with 75 mL of 1,2-dichloroethane. The organic extracts were combined and washed sequentially with 5% sodium hydroxide solution and water. The alkaline washings were combined with the previously collected precipitate and filtered through activated carbon after adjusting the pH to 12 with 5% sodium hydroxide solution. The filtrate was acidified with 50% sulfuric acid and the resulting oil was extracted with ether. The organic phase was dried and the solvent was evaporated to give 3-fluoro-4-hydroxyphenylacetic acid in a yield of 25 g (62% yield). The melting point of the product was 109-111 °C. Mass spectrum (ESI) m/z (relative abundance): 193.0 [M + Na]+.
Purification Methods
Crystallise the acid from water. [Beilstein 10 III 440.]
References
[1] Collection of Czechoslovak Chemical Communications, 1990, vol. 55, # 1, p. 296 - 306
[2] European Journal of Medicinal Chemistry, 2014, vol. 87, p. 508 - 518
[3] Chemische Berichte, 1952, vol. 85, p. 577,580
[4] DRP/DRBP Org.Chem.,
3-FLUORO-4-HYDROXYPHENYLACETIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
3-FLUORO-4-HYDROXYPHENYLACETIC ACID Suppliers
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View Lastest Price from 3-FLUORO-4-HYDROXYPHENYLACETIC ACID manufacturers
- Product
- 3-Fluoro-4-hydroxyphenylacetic acid 458-09-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.1%
- Supply Ability
- 100 tons
- Release date
- 2022-02-21
- Product
- 3-FLUORO-4-HYDROXYPHENYLACETIC ACID 458-09-3
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-03