Aftin-4

Product Name: Aftin-4
CAS No.: 866893-90-5
Chemical Name: Aftin-4
Synonyms: Aftin-4;Aftin-4 >=98% (HPLC);AFTIN-4;AFTIN 4;AFTIN4;N6-methyl-(R)-roscovitine;β-amyloid peptide,inhibit,Abeta,Amyloid-β,Aftin-4,Inhibitor;(R)-2-((6-(Benzyl(methyl)amino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol;1-Butanol, 2-[[9-(1-methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2R)-
CBNumber: CB73381022
Molecular Formula: C20H28N6O
Formula Weight: 368.48
MOL File: 866893-90-5.mol

More

Less

Aftin-4 Property

storage temp.: -20°C
solubility: DMSO: soluble
form: powder
color: white to beige

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1578
Product name: Aftin-4
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $214
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1578
Product name: Aftin-4
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $639
Updated: 2023/06/20

Cayman Chemical

Product number: 27341
Product name: Aftin-4
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 27341
Product name: Aftin-4
Packaging: 25mg
Price: $593
Updated: 2024/03/01

Cayman Chemical

Product number: 27341
Product name: Aftin-4
Packaging: 5mg
Price: $202
Updated: 2024/03/01

More

Less

Aftin-4 Chemical Properties,Usage,Production

Description

Aftin-4 is an inducer of amyloid-β (1-42) (Aβ42). It selectively increases extracellular Aβ42 over Aβ40 production in N2a-AβPP695 cells when used at concentrations ranging from 1 to 100 mM. In vivo, aftin-4 (3-20 nmol/animal, i.c.v.) increases hippocampal Aβ42 content, lipid peroxidation, and production of the pro-inflammatory cytokines IL-1β, IL-6, and TNF-α in mice. It also induces spatial working and spatial reference memory deficits in mice, effects that are reversed by co-administration of the γ-secretase inhibitor BMS-299,897.

Uses

Aftin 4, is an Amyloid-β42 (Aβ42) inducer, that increases Aβ1-42 levels in vivo in mice and provokes rapidly a sustained toxicity highly reminiscent of Alzheimer’s disease (AD).

Biochem/physiol Actions

Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 can thus be used to induce a rapid, acute Alzheimer′s disease-like toxicity in the rodent brain.

storage

+4°C

Aftin-4 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Aftin-4 Suppliers

China 55 India 1 United States 5 Global 61

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9709
Advantage: 58

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 3444
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: QQ:65489617 15618227136
Fax: 21-5161 9052
Email: info@SuperLan-chem.com
Country: China
ProdList: 9445
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12308
Advantage: 58

Medi-tech Bioscientific Co., Ltd.

Tel: 0519-83246372 13585352506
Fax: 0519-83246372
Country: China
ProdList: 1844
Advantage: 58

Twochem Co.Ltd.

Tel: 021-58111628 15800915896
Fax: QQ 3285589261
Country: China
ProdList: 1988
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3238
Advantage: 58

866893-90-5, Aftin-4Related Search:

Aftin-4

AFTIN-4;AFTIN 4;AFTIN4

N6-methyl-(R)-roscovitine

1-Butanol, 2-[[9-(1-methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2R)-

Aftin-4 >=98% (HPLC)

(R)-2-((6-(Benzyl(methyl)amino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol

β-amyloid peptide,inhibit,Abeta,Amyloid-β,Aftin-4,Inhibitor

866893-90-5

66893-90-5

C20H28N6O