ChemicalBook > CAS DataBase List > 5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM

5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM

Product Name
5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM
CAS No.
151126-84-0
Chemical Name
5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM
Synonyms
CL 316243 DISODIUM;CL 316243 disodium s;CL 316243 DISODIUM SALT;5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM;5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylicaciddisodiumsalt;5-[(2R)-2-[[(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO]PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLIC ACID DISODIUM SALT
CBNumber
CB7343089
Molecular Formula
C20H18ClNNa2O7
Formula Weight
465.79
MOL File
151126-84-0.mol
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5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM Property

storage temp. 
Desiccate at -20°C
solubility 
H2O: >10 mg/mL
form 
solid
color 
white
Water Solubility 
Soluble to 100 mM in water
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
1499
Product name
CL316243disodiumsalt
Purity
≥98%(HPLC)
Packaging
10
Price
$214
Updated
2021/12/16
Tocris
Product number
1499
Product name
CL316243disodiumsalt
Purity
≥98%(HPLC)
Packaging
50
Price
$870
Updated
2021/12/16
TRC
Product number
C555003
Product name
CL316243DisodiumSalt
Packaging
5mg
Price
$415
Updated
2021/12/16
ApexBio Technology
Product number
B6766
Product name
CL316243disodiumsalt
Packaging
10mg
Price
$243
Updated
2021/12/16
ApexBio Technology
Product number
B6766
Product name
CL316243disodiumsalt
Packaging
1mg
Price
$60
Updated
2021/12/16
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5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM Chemical Properties,Usage,Production

Description

CL-316243 (151126-84-0) is a potent and selective β3-adrenergic receptor agonist. (EC50= 3 nM) Displays anti-obesity and anti-diabetic effects in mice. It increases brown fat thermogenesis and metabolic rate and decreases blood insulin and glucose levels.1?CL-316243 induces functionally active mitochondrial uncoupling protein (UCP) in white fat.2?Active?in vivo.

Uses

CL 316243 Disodium Salt is a potent and highly selective β3-adrenoceptor agonist.

Biological Activity

Potent and highly selective β 3 -adrenoceptor agonist (EC 50 = 3 nM); > 10000-fold selective over β 1 and β 2 receptors. Increases brown adipose tissue thermogenesis and metabolic rate, and decreases blood insulin and glucose levels following oral administration in vivo .

in vitro

the compound was a potent stimulant of rat adipocyte lipolysis (β3 effect, ec50 = (3.0±0.3) x 10-8 m), had no effect on the rate of contraction of guinea pig atria (β1 effect, ec50 > 10-4 m), and had only a very limited ability to inhibit insulin-stimulated [14c] glucose incorporation into glycogen in isolated rat soleus muacle (β2 effect, ic50 = (3.0±1.0) x 10-5 m) [1].

in vivo

in rat, cl-316,243 treatment resulted in increased growth rates and significant changes in food consumption at the end of the 10-day treatment period. cl-316,243 treatment increased insulin responsiveness and sensitivity in non-insulin-resistant rodent species. the cl-316,243 induced increases in whole-body glucose disposal were due entirely to increases in adipose tissue glucose uptake, while muscle glucose uptake remained unaltered [2].

References

1) Yoshida?et al. (1994),?Anti-obesity and anti-diabetic effects of CL 316,243, a highly specific beta 3-adrenoceptor agonist in yellow KK mice; Life Sci.,?54?491 2) Yoshida?et al. (1998),?β3-Adrenergic agonist induces a functionally active uncoupling protein in fat and slow-twitch muscle fibers; Am. J. Physiol.,?274?E469

5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM Preparation Products And Raw materials

Raw materials

Preparation Products

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5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
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Energy Chemical
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151126-84-0, 5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUMRelated Search:


  • 5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM
  • 5-[(2R)-2-[[(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO]PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLIC ACID DISODIUM SALT
  • 5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylicaciddisodiumsalt
  • CL 316243 DISODIUM
  • CL 316243 DISODIUM SALT
  • CL 316243 disodium s
  • 151126-84-0
  • C20H18ClNO72Na
  • Adrenoceptor
  • Potent and highly selective β3-adrenoceptor agonist