5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM
- Product Name
- 5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM
- CAS No.
- 151126-84-0
- Chemical Name
- 5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM
- Synonyms
- CL 316243 DISODIUM;CL 316243 disodium s;CL 316243 DISODIUM SALT;5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM;5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylicaciddisodiumsalt;5-[(2R)-2-[[(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO]PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLIC ACID DISODIUM SALT
- CBNumber
- CB7343089
- Molecular Formula
- C20H18ClNNa2O7
- Formula Weight
- 465.79
- MOL File
- 151126-84-0.mol
5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM Property
- storage temp.
- Desiccate at -20°C
- solubility
- H2O: >10 mg/mL
- form
- solid
- color
- white
- Water Solubility
- Soluble to 100 mM in water
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 1499
- Product name
- CL316243disodiumsalt
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $214
- Updated
- 2021/12/16
- Product number
- 1499
- Product name
- CL316243disodiumsalt
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $870
- Updated
- 2021/12/16
- Product number
- C555003
- Product name
- CL316243DisodiumSalt
- Packaging
- 5mg
- Price
- $415
- Updated
- 2021/12/16
- Product number
- B6766
- Product name
- CL316243disodiumsalt
- Packaging
- 10mg
- Price
- $243
- Updated
- 2021/12/16
- Product number
- B6766
- Product name
- CL316243disodiumsalt
- Packaging
- 1mg
- Price
- $60
- Updated
- 2021/12/16
5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM Chemical Properties,Usage,Production
Description
CL-316243 (151126-84-0) is a potent and selective β3-adrenergic receptor agonist. (EC50= 3 nM) Displays anti-obesity and anti-diabetic effects in mice. It increases brown fat thermogenesis and metabolic rate and decreases blood insulin and glucose levels.1?CL-316243 induces functionally active mitochondrial uncoupling protein (UCP) in white fat.2?Active?in vivo.
Uses
CL 316243 Disodium Salt is a potent and highly selective β3-adrenoceptor agonist.
Biological Activity
Potent and highly selective β 3 -adrenoceptor agonist (EC 50 = 3 nM); > 10000-fold selective over β 1 and β 2 receptors. Increases brown adipose tissue thermogenesis and metabolic rate, and decreases blood insulin and glucose levels following oral administration in vivo .
in vitro
the compound was a potent stimulant of rat adipocyte lipolysis (β3 effect, ec50 = (3.0±0.3) x 10-8 m), had no effect on the rate of contraction of guinea pig atria (β1 effect, ec50 > 10-4 m), and had only a very limited ability to inhibit insulin-stimulated [14c] glucose incorporation into glycogen in isolated rat soleus muacle (β2 effect, ic50 = (3.0±1.0) x 10-5 m) [1].
in vivo
in rat, cl-316,243 treatment resulted in increased growth rates and significant changes in food consumption at the end of the 10-day treatment period. cl-316,243 treatment increased insulin responsiveness and sensitivity in non-insulin-resistant rodent species. the cl-316,243 induced increases in whole-body glucose disposal were due entirely to increases in adipose tissue glucose uptake, while muscle glucose uptake remained unaltered [2].
References
1) Yoshida?et al. (1994),?Anti-obesity and anti-diabetic effects of CL 316,243, a highly specific beta 3-adrenoceptor agonist in yellow KK mice; Life Sci.,?54?491 2) Yoshida?et al. (1998),?β3-Adrenergic agonist induces a functionally active uncoupling protein in fat and slow-twitch muscle fibers; Am. J. Physiol.,?274?E469
5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM Preparation Products And Raw materials
Raw materials
Preparation Products
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