5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM

Product Name: 5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM
CAS No.: 151126-84-0
Chemical Name: 5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM
Synonyms: CL 316243 DISODIUM;CL 316243 disodium s;CL 316243 DISODIUM SALT;CL-316243 disodium salt, adrenergic-beta3 receptor agonist;5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM;5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylicaciddisodiumsalt;5-[(2R)-2-[[(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO]PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLIC ACID DISODIUM SALT
CBNumber: CB7343089
Molecular Formula: C20H18ClNNa2O7
Formula Weight: 465.79
MOL File: 151126-84-0.mol

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5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM Property

storage temp.: Desiccate at -20°C
solubility: H₂O: >10 mg/mL
form: solid
color: white
Water Solubility: Soluble to 100 mM in water
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 1499
Product name: CL316243disodiumsalt
Purity: ≥98%(HPLC)
Packaging: 10
Price: $214
Updated: 2021/12/16

Tocris

Product number: 1499
Product name: CL316243disodiumsalt
Purity: ≥98%(HPLC)
Packaging: 50
Price: $870
Updated: 2021/12/16

TRC

Product number: C555003
Product name: CL316243DisodiumSalt
Packaging: 5mg
Price: $415
Updated: 2021/12/16

ApexBio Technology

Product number: B6766
Product name: CL316243disodiumsalt
Packaging: 1mg
Price: $60
Updated: 2021/12/16

ApexBio Technology

Product number: B6766
Product name: CL316243disodiumsalt
Packaging: 5mg
Price: $158
Updated: 2021/12/16

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5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM Chemical Properties,Usage,Production

Description

CL-316243 (151126-84-0) is a potent and selective β3-adrenergic receptor agonist. (EC50= 3 nM) Displays anti-obesity and anti-diabetic effects in mice. It increases brown fat thermogenesis and metabolic rate and decreases blood insulin and glucose levels.1?CL-316243 induces functionally active mitochondrial uncoupling protein (UCP) in white fat.2?Active?in vivo.

Uses

CL 316243 Disodium Salt is a potent and highly selective β3-adrenoceptor agonist.

Biological Activity

Potent and highly selective β 3 -adrenoceptor agonist (EC 50 = 3 nM); > 10000-fold selective over β 1 and β 2 receptors. Increases brown adipose tissue thermogenesis and metabolic rate, and decreases blood insulin and glucose levels following oral administration in vivo .

in vitro

the compound was a potent stimulant of rat adipocyte lipolysis (β3 effect, ec50 = (3.0±0.3) x 10-8 m), had no effect on the rate of contraction of guinea pig atria (β1 effect, ec50 > 10-4 m), and had only a very limited ability to inhibit insulin-stimulated [14c] glucose incorporation into glycogen in isolated rat soleus muacle (β2 effect, ic50 = (3.0±1.0) x 10-5 m) [1].

in vivo

in rat, cl-316,243 treatment resulted in increased growth rates and significant changes in food consumption at the end of the 10-day treatment period. cl-316,243 treatment increased insulin responsiveness and sensitivity in non-insulin-resistant rodent species. the cl-316,243 induced increases in whole-body glucose disposal were due entirely to increases in adipose tissue glucose uptake, while muscle glucose uptake remained unaltered [2].

References

[1] Anti-obesity and anti-diabetic effects of CL 316,243, a highly specific beta 3-adrenoceptor agonist in yellow KK mice
[2] T YOSHIDA. beta 3-Adrenergic agonist induces a functionally active uncoupling protein in fat and slow-twitch muscle fibers.[J]. American Journal of Physiology, 1998, 274 3: E469-75. DOI:10.1152/ajpendo.1998.274.3.e469

5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM Preparation Products And Raw materials

Raw materials

Preparation Products

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5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM Suppliers

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151126-84-0, 5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUMRelated Search:

Pioglitazone hydrochloride TARTRONIC ACID KETOMALONIC ACID MONOHYDRATE Phenoxyacetic acid sodium salt MALONIC ACID DISODIUM SALT 2,2-Dimethyl-1,3-benzodioxole 3-CHLOROPHENYLMETHANESULFONYL CHLORIDE MESOXALIC ACID MONOHYDRATE DISODIUM SALT (R)-1-(3-CHLOROPHENYL)-1-HYDROXY-2-AMINOETHANE propanedioate (+/-)-3,4-METHYLENEDIOXY-AMPHETAMINE HYDROCHLORIDE 2-(3-METHYLPHENOXY)PROPANOIC ACID (+/-)-3,4-METHYLENEDIOXY-N-ETHYLAMPHETAMINE HYDROCHLORIDE 5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM 3,4-MDPA (hydrochloride) (+/-)-(R*,R*)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM 2-(4-(2-AMINOETHYL)PHENOXY)ACETIC ACID HYDROCHLORIDE S(+)-3 4-MDMA HCL

5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM

5-[(2R)-2-[[(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO]PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLIC ACID DISODIUM SALT

5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylicaciddisodiumsalt

CL 316243 DISODIUM

CL 316243 DISODIUM SALT

CL 316243 disodium s

CL-316243 disodium salt, adrenergic-beta3 receptor agonist

151126-84-0

C20H18ClNO72Na

Adrenoceptor

Potent and highly selective β3-adrenoceptor agonist