ChemicalBook > CAS DataBase List > 4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER

4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER

Product Name: 4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER
CAS No.: 154548-45-5
Chemical Name: 4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER
Synonyms: N-CBZ-3-carboethoxy-4-piperidone;ETHYL 1-BENZYLOXYCARBONYL-4-OXO-3-PIPERID;Ethyl 1-Cbz-4-oxopiperidine-3-carboxylate;1-Benzyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate;1-O-benzyl 3-O-ethyl 4-oxopiperidine-1,3-dicarboxylate;Ethyl 1-benzyloxycarbonyl-4-oxo-3-piperidinecarboxylate;4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER;1,3-Piperidinedicarboxylic acid, 4-oxo-, 3-ethyl 1-(phenylmethyl) ester
CBNumber: CB7346020
Molecular Formula: C16H19NO5
Formula Weight: 305.33
MOL File: 154548-45-5.mol

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4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER Property

Boiling point:: 446.4±45.0 °C(Predicted)
Density: 1.238±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 11.06±0.20(Predicted)
Appearance: Colorless to light yellow Liquid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: W3368
Product name: 4-Oxopiperidine-1,3-dicarboxylicacid1-benzylester3-ethylester
Packaging: 1g
Price: $281
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 36162
Product name: 1-Benzyl3-ethyl4-oxopiperidine-1,3-dicarboxylate
Purity: 95+%
Packaging: 1g
Price: $460
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0095451
Product name: 4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER
Purity: 95.00%
Packaging: 1G
Price: $984.06
Updated: 2021/12/16

Matrix Scientific

Product number: 076004
Product name: 1-Benzyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate
Purity: 95+%
Packaging: 5g
Price: $998
Updated: 2021/12/16

Matrix Scientific

Product number: 076004
Product name: 1-Benzyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate
Purity: 95+%
Packaging: 1g
Price: $370
Updated: 2021/12/16

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4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER Chemical Properties,Usage,Production

Synthesis

501-53-1

154548-45-5

The general procedure for the synthesis of benzyl ethyl 4-oxo-piperidine-1,3-dicarboxylate from benzyl chloroformate is as follows: a mixture of 1-benzyl-3-ethoxy-4-piperidone hydrochloride (89.0 g, 298.9 mmol) and palladium hydroxide (4.2 g, 5.9 mmol) in methanol (700 mL) was degassed and subjected to 40 psi hydrogen pressure by The reaction was shaken overnight. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filtrate was concentrated. The resulting solid was dissolved in dichloromethane (800 mL) and triethylamine (90.7 g, 897 mmol) was added. After cooling the solution to 0 °C, benzyl chloroformate (56.1 g, 329 mmol) was slowly added. The reaction mixture was stirred at 25 °C for 15 h. The reaction was subsequently quenched with water (500 mL). The aqueous layer was extracted with dichloromethane (2 x 400 mL), the organic layers were combined and dried over anhydrous magnesium sulfate and concentrated to give the crude product. The crude product was purified by silica gel column chromatography (eluent ratio of petroleum ether: ethyl acetate = 5:1) to afford benzyl ethyl 4-oxo-piperidine-1,3-dicarboxylate (72 g, 78% yield), which could be used for subsequent reactions without further purification.

References

[1] Patent: WO2005/49033, 2005, A1. Location in patent: Page/Page column 123

4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER manufacturers

Career Henan Chemical Co

Product: 4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER 154548-45-5
Price: US $6.68/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-10

Career Henan Chemical Co

Product: 4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER 154548-45-5
Price: US $6.68/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-10

154548-45-5, 4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTERRelated Search:

BENZYL ETHYL PIPERIDINE-1,3-DICARBOXYLATE 3-Methyl-4-oxo-1-piperidinecarboxylic acid ethyl ester dimethyl 4-oxopiperidine-1,3-dicarboxylate 1-Cbz-4-Piperidone BENZYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 1-[(Benzyloxy)carbonyl]-3-piperidinecarboxylic acid 1-BOC-3-METHYL-PIPERIDIN-4-ONE 4-OXO-PIPERIDINE-3-CARBOXYLIC ACID ETHYL ESTER PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-METHYL ESTER Methyl 1-methyl-4-oxopiperidine-3-carboxylate 3-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER 4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER 4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 4-Oxo-1,3-piperidinedicarboxylic acid 1-benzyl ester 3-methyl ester

1-Benzyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate

Ethyl 1-benzyloxycarbonyl-4-oxo-3-piperidinecarboxylate

1-O-benzyl 3-O-ethyl 4-oxopiperidine-1,3-dicarboxylate

Ethyl 1-Cbz-4-oxopiperidine-3-carboxylate

4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER

1,3-Piperidinedicarboxylic acid, 4-oxo-, 3-ethyl 1-(phenylmethyl) ester

ETHYL 1-BENZYLOXYCARBONYL-4-OXO-3-PIPERID

N-CBZ-3-carboethoxy-4-piperidone

154548-45-5

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