Ethyl N-Cbz-piperidine-3-carboxylate

Product Name: Ethyl N-Cbz-piperidine-3-carboxylate
CAS No.: 310454-53-6
Chemical Name: Ethyl N-Cbz-piperidine-3-carboxylate
Synonyms: N-Cbz-PIPERIDINE-3-carboxylate;BENZYL ETHYL PIPERIDINE-1,3-DICARBOXYLATE;CBZ-PIPERIDINE-3-CARBOXYLIC ACID ETHYL ESTER;1-Benzyl 3-ethyl piperidine-1,3-dicarboxylate;Benzyl ethyl piperidine-1,3-dicarboxylate 97%;1-Cbz-piperidine-3-carboxylic acid ethyl ester;1-O-benzyl 3-O-ethyl piperidine-1,3-dicarboxylate;1,3-Piperidinedicarboxylic acid, 3-ethyl 1-(phenylMethyl) ester;(3S)-piperidine-1,3-dicarboxylic acid O3-ethyl ester O1-(phenylmethyl) ester
CBNumber: CB9243392
Molecular Formula: C16H21NO4
Formula Weight: 291.34
MOL File: 310454-53-6.mol

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Ethyl N-Cbz-piperidine-3-carboxylate Property

Boiling point:: 403.7±45.0 °C(Predicted)
Density: 1.165±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: -2.45±0.40(Predicted)
Appearance: Colorless to light yellow Liquid

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Safety

Hazard Codes: Xi
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B410823
Product name: 1-Benzyl3-EthylPiperidine-1,3-dicarboxylate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: X0398
Product name: EthylN-Cbz-piperidine-3-carboxylate
Packaging: 10g
Price: $47
Updated: 2021/12/16

Matrix Scientific

Product number: 126197
Product name: 1-Benzyl3-ethylpiperidine-1,3-dicarboxylate
Purity: >95%
Packaging: 5g
Price: $64
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140648
Product name: 1-Benzyl 3-ethyl piperidine-1,3-dicarboxylate
Packaging: 10g
Price: $80
Updated: 2021/12/16

AK Scientific

Product number: J98882
Product name: EthylN-Cbz-piperidine-3-carboxylate
Packaging: 25g
Price: $80
Updated: 2021/12/16

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Ethyl N-Cbz-piperidine-3-carboxylate Chemical Properties,Usage,Production

Synthesis

501-53-1

71962-74-8

310454-53-6

Step 1: Synthesis of 1-benzyl 3-ethylpiperidine-1,3-dicarboxylate Benzyl chloroformate (191 mL, 1.34 mol) was slowly added dropwise to a cooled solution of ethyl piperidine-3-carboxylate (200 g, 1.27 mol) and triethylamine (266 mL, 1.91 mol) in dichloromethane (1000 mL) at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred for 3 hours. Upon completion of the reaction, the reaction was quenched by the addition of 1N HCl aqueous solution. The reaction mixture was extracted several times with dichloromethane and the organic phases were combined. The organic phase was washed sequentially with water, saturated aqueous NaHCO3 solution, water and brine, and then dried with anhydrous MgSO4. After filtration, the filtrate was concentrated under reduced pressure to afford the target product 1-benzyl 3-ethylpiperidine-1,3-dicarboxylate as an oil (359.8 g, 97% yield).LC/MS analysis showed m/z 292.2 ([M+H]+).

References

[1] Tetrahedron Letters, 2011, vol. 52, # 26, p. 3266 - 3270
[2] Patent: US2008/318991, 2008, A1. Location in patent: Page/Page column 7-8
[3] Patent: WO2009/140320, 2009, A1. Location in patent: Page/Page column 72
[4] Patent: WO2013/12829, 2013, A1. Location in patent: Paragraph 00273
[5] Patent: US8080566, 2011, B1. Location in patent: Page/Page column 44

Ethyl N-Cbz-piperidine-3-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl N-Cbz-piperidine-3-carboxylate Suppliers

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View Lastest Price from Ethyl N-Cbz-piperidine-3-carboxylate manufacturers

Career Henan Chemical Co

Product: BENZYL ETHYL PIPERIDINE-1,3-DICARBOXYLATE 310454-53-6
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 467
Release date: 2019-09-01

310454-53-6, Ethyl N-Cbz-piperidine-3-carboxylateRelated Search:

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CBZ-PIPERIDINE-3-CARBOXYLIC ACID ETHYL ESTER

BENZYL ETHYL PIPERIDINE-1,3-DICARBOXYLATE

Benzyl ethyl piperidine-1,3-dicarboxylate 97%

1-Benzyl 3-ethyl piperidine-1,3-dicarboxylate

1,3-Piperidinedicarboxylic acid, 3-ethyl 1-(phenylMethyl) ester

1-Cbz-piperidine-3-carboxylic acid ethyl ester

1-O-benzyl 3-O-ethyl piperidine-1,3-dicarboxylate

(3S)-piperidine-1,3-dicarboxylic acid O3-ethyl ester O1-(phenylmethyl) ester

N-Cbz-PIPERIDINE-3-carboxylate

310454-53-6