ChemicalBook > CAS DataBase List > Ethyl N-Cbz-piperidine-3-carboxylate

Ethyl N-Cbz-piperidine-3-carboxylate

Product Name
Ethyl N-Cbz-piperidine-3-carboxylate
CAS No.
310454-53-6
Chemical Name
Ethyl N-Cbz-piperidine-3-carboxylate
Synonyms
N-Cbz-PIPERIDINE-3-carboxylate;BENZYL ETHYL PIPERIDINE-1,3-DICARBOXYLATE;CBZ-PIPERIDINE-3-CARBOXYLIC ACID ETHYL ESTER;1-Benzyl 3-ethyl piperidine-1,3-dicarboxylate;Benzyl ethyl piperidine-1,3-dicarboxylate 97%;1-Cbz-piperidine-3-carboxylic acid ethyl ester;1-O-benzyl 3-O-ethyl piperidine-1,3-dicarboxylate;1,3-Piperidinedicarboxylic acid, 3-ethyl 1-(phenylMethyl) ester;(3S)-piperidine-1,3-dicarboxylic acid O3-ethyl ester O1-(phenylmethyl) ester
CBNumber
CB9243392
Molecular Formula
C16H21NO4
Formula Weight
291.34
MOL File
310454-53-6.mol
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Ethyl N-Cbz-piperidine-3-carboxylate Property

Boiling point:
403.7±45.0 °C(Predicted)
Density 
1.165±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
-2.45±0.40(Predicted)
Appearance
Colorless to light yellow Liquid
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Safety

Hazard Codes 
Xi
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B410823
Product name
1-Benzyl3-EthylPiperidine-1,3-dicarboxylate
Packaging
50mg
Price
$45
Updated
2021/12/16
Apolloscientific
Product number
OR10941
Product name
Benzylethylpiperidine-1,3-dicarboxylate
Purity
97%
Packaging
1g
Price
$15
Updated
2021/12/16
SynQuest Laboratories
Product number
4H23-1-W2
Product name
Benzyl ethyl piperidine-1,3-dicarboxylate
Purity
97%
Packaging
1g
Price
$16
Updated
2021/12/16
Apolloscientific
Product number
OR10941
Product name
Benzylethylpiperidine-1,3-dicarboxylate
Purity
97%
Packaging
5g
Price
$19
Updated
2021/12/16
SynQuest Laboratories
Product number
4H23-1-W2
Product name
Benzyl ethyl piperidine-1,3-dicarboxylate
Purity
97%
Packaging
5G
Price
$21
Updated
2021/12/16
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Ethyl N-Cbz-piperidine-3-carboxylate Chemical Properties,Usage,Production

Synthesis

501-53-1

71962-74-8

310454-53-6

Step 1: Synthesis of 1-benzyl 3-ethylpiperidine-1,3-dicarboxylate Benzyl chloroformate (191 mL, 1.34 mol) was slowly added dropwise to a cooled solution of ethyl piperidine-3-carboxylate (200 g, 1.27 mol) and triethylamine (266 mL, 1.91 mol) in dichloromethane (1000 mL) at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred for 3 hours. Upon completion of the reaction, the reaction was quenched by the addition of 1N HCl aqueous solution. The reaction mixture was extracted several times with dichloromethane and the organic phases were combined. The organic phase was washed sequentially with water, saturated aqueous NaHCO3 solution, water and brine, and then dried with anhydrous MgSO4. After filtration, the filtrate was concentrated under reduced pressure to afford the target product 1-benzyl 3-ethylpiperidine-1,3-dicarboxylate as an oil (359.8 g, 97% yield).LC/MS analysis showed m/z 292.2 ([M+H]+).

References

[1] Tetrahedron Letters, 2011, vol. 52, # 26, p. 3266 - 3270
[2] Patent: US2008/318991, 2008, A1. Location in patent: Page/Page column 7-8
[3] Patent: WO2009/140320, 2009, A1. Location in patent: Page/Page column 72
[4] Patent: WO2013/12829, 2013, A1. Location in patent: Paragraph 00273
[5] Patent: US8080566, 2011, B1. Location in patent: Page/Page column 44

Ethyl N-Cbz-piperidine-3-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ethyl N-Cbz-piperidine-3-carboxylate manufacturers

Career Henan Chemical Co
Product
BENZYL ETHYL PIPERIDINE-1,3-DICARBOXYLATE 310454-53-6
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
JD 467
Release date
2019-09-01

310454-53-6, Ethyl N-Cbz-piperidine-3-carboxylateRelated Search:

1-(Methylsulfonyl)-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine BENZYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 1-Cbz-4-hydroxymethylpiperidine 1-N-CBZ-NIPECOTAMIDE 4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER BENZYL ETHYL PIPERIDINE-1,3-DICARBOXYLATE N-CBZ-3-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER ETHYL (S)-1-CBZ-NIPECOTATE (R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER

  • CBZ-PIPERIDINE-3-CARBOXYLIC ACID ETHYL ESTER
  • BENZYL ETHYL PIPERIDINE-1,3-DICARBOXYLATE
  • Benzyl ethyl piperidine-1,3-dicarboxylate 97%
  • 1-Benzyl 3-ethyl piperidine-1,3-dicarboxylate
  • 1,3-Piperidinedicarboxylic acid, 3-ethyl 1-(phenylMethyl) ester
  • 1-Cbz-piperidine-3-carboxylic acid ethyl ester
  • 1-O-benzyl 3-O-ethyl piperidine-1,3-dicarboxylate
  • (3S)-piperidine-1,3-dicarboxylic acid O3-ethyl ester O1-(phenylmethyl) ester
  • N-Cbz-PIPERIDINE-3-carboxylate
  • 310454-53-6