1-Cbz-4-hydroxymethylpiperidine

Product Name: 1-Cbz-4-hydroxymethylpiperidine
CAS No.: 122860-33-7
Chemical Name: 1-Cbz-4-hydroxymethylpiperidine
Synonyms: Z-PIC(4)-OL;Z-ISONIPECOTINOL;BUTTPARK 75\50-51;Z-ISONICOT(H6)-OL;N-Cbz-4-(hydroxymethyL;N- Cbz-4-piperidinemethanol;N-CARBOBENZOXY-4-PIPECOLINOL;1-CBZ-4-HYDROXYMETHYLPIPERIDINE;1-N-CBZ-HYDROXYMETHYL-PIPERIDINE;N-Cbz-4-(hydroxymethyl)piperidine
CBNumber: CB2135971
Molecular Formula: C14H19NO3
Formula Weight: 249.31
MOL File: 122860-33-7.mol

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1-Cbz-4-hydroxymethylpiperidine Property

Boiling point:: 396.4±25.0 °C(Predicted)
Density: 1.162±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 14.94±0.10(Predicted)
Appearance: Colorless to off-white Solid-liquid mixture
CAS DataBase Reference: 122860-33-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39-37/39
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: C227700
Product name: 1-N-Cbz-hydroxymethyl-piperidine
Packaging: 1g
Price: $55
Updated: 2021/12/16

TRC

Product number: C227700
Product name: 1-N-Cbz-hydroxymethyl-piperidine
Packaging: 5g
Price: $70
Updated: 2021/12/16

Chem-Impex

Product number: 17102
Product name: 1-Z-4-Hydroxymethylpiperidine,≥98%
Purity: ≥98%
Packaging: 5G
Price: $29.12
Updated: 2021/12/16

Chem-Impex

Product number: 17102
Product name: 1-Z-4-Hydroxymethylpiperidine,≥98%
Purity: ≥98%
Packaging: 1G
Price: $13.5
Updated: 2021/12/16

ChemScene

Product number: CS-W002888
Product name: Benzyl4-(hydroxymethyl)piperidine-1-carboxylate
Purity: ≥97.0%
Packaging: 100g
Price: $104
Updated: 2021/12/16

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1-Cbz-4-hydroxymethylpiperidine Chemical Properties,Usage,Production

Uses

1-N-Cbz-hydroxymethyl-piperidine is an intermediate used in the synthesis of benzoyloxyethylpiperidinylmethylamine as fluorescent antagonists for human 5-HT4 receptors. It is also used to prepare diaminobutane derivatives as potent Ca2+-Permeable AMPA receptor antagonists.

Synthesis

6457-49-4

501-53-1

122860-33-7

General procedure for the synthesis of N-CBZ-4-piperidinemethanol (1-CBZ-4-hydroxymethylpiperidine) from 4-(hydroxymethyl)piperidine and benzyl chloroformate: 4-(hydroxymethyl)piperidine (2.0 g, 17.4 mmol) was dissolved in anhydrous dichloromethane (DCM, 100 mL), and the solution was cooled to 0 °C and stirred. Triethylamine (4.8 mL, 34.8 mmol) and benzyl chloroformate (3.7 mL, 34.8 mmol) were added sequentially, then the reaction mixture was slowly warmed to room temperature and stirring was continued for 2 hours. Upon completion of the reaction, the mixture was transferred to a partition funnel and layered with DCM (50 mL) and water (30 mL). The organic phase was separated and the aqueous phase was extracted with DCM (2 x 50 mL). All organic phases were combined, washed once with brine (30 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by column chromatography using a gradient elution with hexane/EtOAc (70% to 100%) to afford 3.85 g (89% yield) of N-benzyloxycarbonyl-4-(hydroxymethyl)piperidine (E-12) as a clear oil. Its 1H NMR (CDCl3) data were as follows: δ 1.17 (m, 2H), 1.72 (m, 3H), 2.15 (br s, 1H), 2.78 (t, 2H, J = 12 Hz), 3.47 (d, 2H, J = 6.04 Hz), 4.20 (d, 2H, J = 11.68 Hz), 5.12 (s, 2H), 7.33 (m , 5H).

References

[1] Patent: WO2005/80394, 2005, A1. Location in patent: Page/Page column 131
[2] European Journal of Organic Chemistry, 2008, # 25, p. 4277 - 4295
[3] Patent: WO2010/46780, 2010, A2. Location in patent: Page/Page column 63-64
[4] Journal of the American Chemical Society, 2017, vol. 139, # 24, p. 8110 - 8113
[5] Patent: US2003/55244, 2003, A1

1-Cbz-4-hydroxymethylpiperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Cbz-4-hydroxymethylpiperidine Suppliers

Belgium 1 China 142 France 2 Germany 2 India 3 Japan 1 United Kingdom 5 United States 28 Global 184

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View Lastest Price from 1-Cbz-4-hydroxymethylpiperidine manufacturers

Career Henan Chemical Co

Product: 1-Cbz-4-hydroxymethylpiperidine 122860-33-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-12-26

122860-33-7, 1-Cbz-4-hydroxymethylpiperidineRelated Search:

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1-CBZ-4-HYDROXYMETHYLPIPERIDINE

1-N-CBZ-HYDROXYMETHYL-PIPERIDINE

4-HYDROXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER

N-CARBOBENZOXY-4-PIPECOLINOL

N-CARBOBENZOXY-4-PIPERIDINEMETHANOL

N-CARBOBENZOXY-HEXAHYDROISONICOTINOL

N-(BENZYLOXYCARBONYL)-4-(HYDROXYMETHYL)PIPERIDINE

Z-ISONICOT(H6)-OL

Z-ISONIPECOTINOL

Z-PIC(4)-OL

BUTTPARK 75\50-51

BENZYL 4-(HYDROXYMETHYL)PIPERIDINE-1-CARBOXYLATE

BENZYL 4-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE

1-N-Cbz-4-Hydroxymethyl-piperidine

N-Cbz-4-(hydroxymethyl)piperidine

N-(Benzyloxycarbonyl)-4-(Hydroxymethyl)piperidine, 97 %

1-Piperidinecarboxylic acid, 4-(hydroxyMethyl)-, phenylMethyl ester

1-Piperidinecarboxylic acid, 4-(hydroxymethyl)-, phenylmethyl ester (9CI)

Phenylmethyl 4-(hydroxymethyl)-1-piperidinecarboxylate

N-Cbz-4-PiperidineMethanolor benzyl-4-(hydroxyMethyl)tetrahydro-1(2h)-pyridinecarboxylate

N-Cbz-4-(hydroxymethyL

1-Piperidinecarboxylic acid, 4-(hydroxymethyl)-, phenylmethyl ester (9CI, ACI)

4-(hydroxymethyl)-1-Piperidinecarboxylic acid phenylmethyl ester (9CI ACI)

benzyl 4-(hydroxymethyl)piperidine-N-carboxylate

N- Cbz-4-piperidinemethanol

1-Cbz-4-hydroxymethylpiperidine - [H12353]

Benzyl 4-(hydroxymethyl)piperidin-1-carboxylate

122860-33-7

112860-33-7

ALCOHOL

pharmacetical

Piperidine

Alcohols and Derivatives

Amines and Anilines