4-(AMINOMETHYL)BENZENESULFONAMIDE
- Product Name
- 4-(AMINOMETHYL)BENZENESULFONAMIDE
- CAS No.
- 138-39-6
- Chemical Name
- 4-(AMINOMETHYL)BENZENESULFONAMIDE
- Synonyms
- Homosul;Homonal;Emilene;Mesudin;Maphenid;Malfamin;Mesudrin;Ambamide;Neofamid;Septicid
- CBNumber
- CB7347830
- Molecular Formula
- C7H10N2O2S
- Formula Weight
- 186.23
- MOL File
- 138-39-6.mol
4-(AMINOMETHYL)BENZENESULFONAMIDE Property
- Melting point:
- 177-178℃ (decomposition)
- Boiling point:
- 382.0±44.0 °C(Predicted)
- Density
- 1.345±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 10.16±0.10(Predicted)
- color
- Light Beige to Beige
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 23995
- Product name
- Mafenide Acetate
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 23995
- Product name
- Mafenide Acetate
- Purity
- ≥95%
- Packaging
- 250mg
- Price
- $67
- Updated
- 2024/03/01
- Product number
- 23995
- Product name
- Mafenide Acetate
- Purity
- ≥95%
- Packaging
- 500mg
- Price
- $96
- Updated
- 2024/03/01
- Product number
- A613490
- Product name
- 4-Aminomethylbenzenesulfonamide
- Packaging
- 250mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 058351
- Product name
- 4-(Aminomethyl)benzenesulfonamide
- Packaging
- 5g
- Price
- $150
- Updated
- 2021/12/16
4-(AMINOMETHYL)BENZENESULFONAMIDE Chemical Properties,Usage,Production
Originator
Sulfamylon,Winthrop,US,1949
Uses
antibacterial
Definition
ChEBI: Mafenide is an aromatic amine.
Manufacturing Process
For the preparation of mafenide 50 g of acetylbenzylamine are introduced while stirring into 150 cc of chlorosulfonic acid, whereby the temperature is kept below 40°C by external cooling. After several hours' storing at ordinary temperature the mixture is heated for 1 hour in the boiling water-bath and after cooling, poured on to ice. Thereupon the 4-acetylaminoethylbenzenesulfonic acid chloride precipitates at first in an oily form, but solidifies after short stirring to crystals. The product sucked off and washed with cold water is introduced into a 10% aqueous ammonia solution. Thereby dissolution takes place while heating and after a short time the 4- acetylaminomethyl-benzenesulfonic acid amide precipitates in a crystalline form. After heating to 70°C for 30 minutes the solution is cooled, filtered with suction and washed out. The product is obtained when recrystallized from water or dilute alcohol in colorless crystals melting at 177%. It is readily soluble in warm water, extremely readily soluble in dilute sodium hydroxide solution.
brand name
Sulfamylon (Sterling Winthrop).
Therapeutic Function
Antibacterial
Pharmaceutical Applications
p-Aminomethylbenzene sulfonamide; Sulfamylon.
A topical agent formerly used extensively in burns, especially
for its action in suppressing Ps. aeruginosa. It is rapidly
absorbed through burned skin and is unusual in that it is not neutralized by p-aminobenzoic acid or by tissue exudates.
Disadvantages of its use are local pain and burning, a variety
of allergic reactions including erythema multiforme and
its capacity to inhibit carbonic anhydrase, necessitating careful
observation to detect the development of metabolic acidosis.
Its metabolite, p-carboxybenzene sulfonamide, also
inhibits carbonic anhydrase but has no antibacterial activity.
Mafenide propionate was formerly used in ophthalmic
preparations.
Synthesis
Maphenide, n-(aminomethyl)-benzenesulfamide (33.1.48), is structurally somewhat different from all drugs examined above in that the amino group in the p-position to the sulfonamide group is distanced from the benzene ring by one methyl group. This drug is synthesized from N-benzylacetamide, subsequent reaction of which with chlorosulfonic acid and then with ammonia gives 4-(acetamidomethyl)-benzene-sulfonamide (33.1.47). Hydrolyzing this product with a base gives maphenid.
Synonyms of this drug are marfanil, mezudin, ambamide, septicid, and others.
4-(AMINOMETHYL)BENZENESULFONAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(AMINOMETHYL)BENZENESULFONAMIDE manufacturers
- Product
- Mafenide 138-39-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Mafenide 138-39-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08