MITOQ
- Product Name
- MITOQ
- CAS No.
- 444890-41-9
- Chemical Name
- MITOQ
- Synonyms
- MitoQ10;Mitoquinol(MITOQ);Mitoquinone (Mito-Q;Mitoquinone Discontinued;Mitoquinone | Mitochondria-targeted antioxidant
- CBNumber
- CB73480165
- Molecular Formula
- C37H44O4P+
- Formula Weight
- 583.73
- MOL File
- 444890-41-9.mol
MITOQ Property
- storage temp.
- -20°
- solubility
- Soluble in DMSO (70 mg/mL); ethanol (30 mg/mL)
- form
- waxy solid
- color
- Brown
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
MITOQ Chemical Properties,Usage,Production
Description
Mitoquinone (444890-40-9) is a mitochondria-targeted antioxidant. Displays cardio- and neuroprotective effects.1?Displays beneficial effects in mouse models of Alzheimer’s disease.2?Mitoquinone protects pancreatic β-cells against oxidative stress and improves insulin secretion.3 Cell permeable.? Mesylate salt (Cat# 10-3914)and mesylate cyclodextrin complex (Cat# 10-3915) are also available.
Uses
Mitoquinone is a mitochondria-targeted antioxidant.
References
1) Ghosh et al. (2010), Neuroprotection by a mitochondria-targeted drug in a Parkinson’s disease model; Free Radic. Biol. Med., 49 1674 2) McManus et al. (2011), The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease; J. Neurosci., 31 15703 3) Lim et al. (2011), Mitochondria-targeted antioxidants protect pancreatic β-cells against oxidative stress and improve insulin secretion in glucotoxicity and glucolipotoxicity; Cell Physiol. Biochem., 28 873 4) Demers-Lamarche et al. (2016) Loss of Mitochondrial Function Impairs Lysosomes; J. Biol. Chem. 291 10263 [Focus Citation] 5) Zhou et al. (2018) Mitochondrial-targeted antioxidant MitoQ provides neuroprotection and reduces neuronal apoptosis in experimental traumatic brain injury possibly via the Nrf2-ARE pathway; Am. J. Transl. Res., 10 1887 [Focus Citation] 6) Xiao et al. (2017) The mitochondrial-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1; Redox Biol., 11 297 [Focus Citation] 7) Deng et al. (2019), Myo-inositol oxygenase expression profile modulates pathogenic ferroptosis in the renal proximal tubule; J. Clin. Invest., 129 5033 [Focus Citation]
MITOQ Preparation Products And Raw materials
Raw materials
Preparation Products
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