Description Features In vitro
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Necrostatin-1

Description Features In vitro
Product Name
Necrostatin-1
CAS No.
4311-88-0
Chemical Name
Necrostatin-1
Synonyms
Nec 1;CS-959;NECROSTATIN-1;MTH-DL-TRYPTOPHAN;IFLAB-BB F0911-6127;Necrostatin-1, >=98%;Necrostatin-1 USP/EP/BP;NECROSTATIN1; NECROSTATIN 1;Methylthiohydantoin-DL-tryptophan;Necrostatin-1 - CAS 4311-88-0 - Calbiochem
CBNumber
CB6776886
Molecular Formula
C13H13N3OS
Formula Weight
259.33
MOL File
4311-88-0.mol
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Necrostatin-1 Property

Melting point:
151℃
Boiling point:
441.9±37.0 °C(Predicted)
Density 
1.40±0.1 g/cm3 (20 ºC 760 Torr)
Flash point:
93.3℃
storage temp. 
−20°C
solubility 
DMSO: >10 mg/mL
form 
solid
pka
9.46±0.40(Predicted)
Sensitive 
Light Sensitive
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Safety

Risk Statements 
36/37/39
Safety Statements 
36/37/39
WGK Germany 
3
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
480065
Product name
Necrostatin-1
Packaging
5mg
Price
$109.15
Updated
2021/03/22
Sigma-Aldrich
Product number
N9037
Product name
Necrostatin-1
Purity
≥98% (HPLC)
Packaging
10mg
Price
$164
Updated
2021/03/22
TCI Chemical
Product number
N1174
Product name
Necrostatin-1
Packaging
25MG
Price
$161
Updated
2021/03/22
TCI Chemical
Product number
N1174
Product name
Necrostatin-1
Packaging
100MG
Price
$388
Updated
2021/03/22
Alfa Aesar
Product number
J65341
Product name
Necrostatin-1
Packaging
20mg
Price
$112
Updated
2021/03/22
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Necrostatin-1 Chemical Properties,Usage,Production

Description

Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM in 293T cells.

Features

A powerful tool for characterizing the role of necroptosis with characterized primary target.

In vitro

Necrostatin-1 (1-100 μM) inhibits the autophosphorylation of overexpressed and endogenous RIP1.It is found RIP1 is the primary cellular target responsible for the antinecroptosis activity of Necrostatin-1. Necrostatin-1 efficiently suppresses necroptotic cell death triggered by an array of stimuli in a variety of cell types. Necrostatin-1, previously identified as small-molecule inhibitor of necroptosis, inhibits RIP kinase-induced necroptosis and inhibits TNF-α-induced necroptosis in jurkat cells with EC50 of 490 nM.

Uses

Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.

Uses

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Necrostatin-1 is an inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells. Necrostatin-1 has been used to investigate the pathological importance of necroptosis in ischemic brain injury and myocardial infarction.

Biological Activity

ATP-competitive death domain receptor-associated adaptor kinase (RIP1) allosteric inhibitor (EC 50 = 182 nM). Blocks non-apoptotic cell death via inhibition of a specific cellular pathway, necroptosis, which leads to necrosis (EC 50 = 494 nM). Reduces ischemic brain injury in a mouse model of stroke.

Necrostatin-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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Necrostatin-1 Suppliers

Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9918
Advantage
58
Tianjin Kailiqi Biotechnology Co., Ltd.
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
1151
Advantage
55
Shanghai JiYi Biotechnology Co. Ltd.
Fax
-
Email
sales@shjiyipharmatech.com
Country
China
ProdList
1167
Advantage
55
Heze Development Zone chuangli Chemical Co., Ltd.
Tel
0530-5296766-
Fax
0530-529 6766
Email
sales@chuangli-chem.com
Country
China
ProdList
596
Advantage
55
Shanghai Boyle Chemical Co., Ltd.
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2926
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15877
Advantage
69
VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
ProdList
510
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202- ;021-54308259-
Fax
+86-21-64545202
Email
info@hanhonggroup.com;info@hanhonggroup.com
Country
China
ProdList
43255
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32358
Advantage
50
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View Lastest Price from Necrostatin-1 manufacturers

career henan chemical co
Product
Necrostatin-1 4311-88-0
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-09-03

4311-88-0, Necrostatin-1Related Search:


  • Necrostatin-1, >=98%
  • CS-959
  • NECROSTATIN1; NECROSTATIN 1
  • Necrostatin-1 - CAS 4311-88-0 - Calbiochem
  • IFLAB-BB F0911-6127
  • 5-(INDOL-3-YLMETHYL)-3-METHYL-2-THIO-HYDANTOIN
  • NECROSTATIN-1
  • MTH-DL-TRYPTOPHAN
  • MTH-DL-Tryptophan Methylthiohydantoin-DL-tryptophan
  • 5-(1H-INDOL-3-YLMETHYL)-3-METHYL-2-THIOXO-4-IMIDAZOLIDINONE
  • 5-(1H-Indole-3ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone
  • 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidazolidinone, 5-(Indol-3-ylmethyl)-3-methyl-2-thio-hydantoin, MTH-DL-Tryptophan
  • Nec 1
  • Methylthiohydantoin-DL-tryptophan, MTH-DL-tryptophan
  • 4-IMidazolidinone, 5-(1H-indol-3-ylMethyl)-3-Methyl-2-thioxo-
  • 5-((1H-indol-3-yl)Methyl)-3-Methyl-2-thioxoiMidazolidin-4-one
  • 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone Necrostatin 1
  • Necrostatin 1 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone
  • Methylthiohydantoin-DL-tryptophan
  • NECROSTATIN1;NECROSTATIN 1;METHYLTHIOHYDANTOIN-DL-TRYPTOPHAN
  • Necrostatin-1 USP/EP/BP
  • 4311-88-0
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Apoptosis and Cell Cycle
  • Apoptosis Inhibitors
  • BioChemical
  • Inhibitors
  • Apoptosis Inhibitors
  • Miscellaneous Signaling
  • Inhibitor