(±)11(12)-EET

Product Name: (±)11(12)-EET
CAS No.: 123931-40-8
Chemical Name: (±)11(12)-EET
Synonyms: 11,12-Epoxy-(5Z,8Z,14Z)-eicosatrienoic acid ~100 mug/mL in ethanol, >=95%;5,8-Decadienoic acid, 10-[(2S,3R)-3-(2Z)-2-octen-1-yl-2-oxiranyl]-, (5Z,8Z)-
CBNumber: CB22589778
Molecular Formula: C20H32O3
Formula Weight: 320.47
MOL File: 123931-40-8.mol

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(±)11(12)-EET Property

Boiling point:: 461.8±33.0 °C(Predicted)
Density: 0.983±0.06 g/cm3(Predicted)
Flash point:: 9℃
storage temp.: -20°C
solubility: DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS pH 7.2: 1 mg/ml
pka: 4.75±0.10(Predicted)

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Safety

Hazard Codes: F
Risk Statements: 11
Safety Statements: 7-16
RIDADR: UN1170 - class 3 - PG 2 - Ethanol, solution
WGK Germany: 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E5641
Product name: 11,12-Epoxy-(5Z,8Z,14Z)-eicosatrienoic acid
Purity: ~100?μg/mLinethanol,≥95%
Packaging: 25μg
Price: $294
Updated: 2024/03/01

Cayman Chemical

Product number: 50511
Product name: (±)11(12)-EET
Purity: ≥95%
Packaging: 25μg
Price: $44
Updated: 2023/06/20

Cayman Chemical

Product number: 50511
Product name: (±)11(12)-EET
Purity: ≥95%
Packaging: 50μg
Price: $79
Updated: 2023/06/20

Cayman Chemical

Product number: 50511
Product name: (±)11(12)-EET
Purity: ≥95%
Packaging: 100μg
Price: $138
Updated: 2023/06/20

Cayman Chemical

Product number: 50511
Product name: (±)11(12)-EET
Purity: ≥95%
Packaging: 500μg
Price: $428
Updated: 2023/06/20

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(±)11(12)-EET Chemical Properties,Usage,Production

Description

(±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms CYP2C23 and CYP2C24 while CYP2B2 produces a higher proportion of 11(S),12(R)-EET. 11(12)-EET has been shown, along with 8(9)-EET , to play a role in the recovery of depleted calcium pools in cultured smooth muscle cells. It also inhibits basolateral 18-pS potassium channels in the renal cortical collecting duct when used at a concentration of 100 nM. 11(12)-EET (50 μg/kg per day) increases adhesion of isolated peripheral blood leukocytes in a chamber coated with P-selectin and ICAM-1 but does not affect choroidal neovascularization size following laser photocoagulation. It also has anti-inflammatory, angiogenic, and cardioprotective properties.

Uses

14(15)-Epoxy-5Z,8Z,11Z-eicosatrienoic Acid-D11 is a deuterium labelled 14(15)-Epoxy-5Z,8Z,11Z-eicosatrienoic Acid (E350670), which is a useful research chemical that acts as an endothelium-derived hyperpolarizing factor in bovine coronary arteries to mediate vascular effects of vasoactive hormones.

(±)11(12)-EET Preparation Products And Raw materials

Raw materials

Preparation Products

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(±)11(12)-EET Suppliers

China 9 India 1 United States 5 Global 15

Shanghai Aladdin Bio-Chem Technology Co.,LTD

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123931-40-8, (±)11(12)-EETRelated Search:

Ursolic acid Necrostatin-1 CYTOCHALASIN E Shikonin 5-hydroxyeicosatetraenoic acid lactone

5,8-Decadienoic acid, 10-[(2S,3R)-3-(2Z)-2-octen-1-yl-2-oxiranyl]-, (5Z,8Z)-

11,12-Epoxy-(5Z,8Z,14Z)-eicosatrienoic acid ~100 mug/mL in ethanol, >=95%

123931-40-8