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CYTOCHALASIN E

Product Name
CYTOCHALASIN E
CAS No.
36011-19-5
Chemical Name
CYTOCHALASIN E
Synonyms
CYTOCHALACINE;CYTOCHALICINE;CYTOCHALASIN E;CYTOCHALASIN 3;CYTOCHALASIN E(RG);CYTOCHALASIN E USP/EP/BP;LAJXCUNOQSHRJO-DXUWGLIISA-N;CYTOCHALASIN E(RG) Please Call;CYTOCHALASIN E, ASPERGILLUS CLAVATUS;CYTOCHALASIN E FROM ASPERGILLUSCLAVATUS
CBNumber
CB5192252
Molecular Formula
C28H33NO7
Formula Weight
495.56
MOL File
36011-19-5.mol
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CYTOCHALASIN E Property

Melting point:
206 °C
Boiling point:
587.59°C (rough estimate)
Density 
1.2415 (rough estimate)
refractive index 
1.6290 (estimate)
storage temp. 
-20°C
solubility 
DMF: 11 mg/ml; DMF:PBS (pH7.2) (1:30): 0.03 mg/ml; DMSO: 10 mg/ml; Ethanol: 2 mg/ml
form 
White solid.
pka
11.22±0.70(Predicted)
color 
White to off-white
BRN 
1096975
LogP
1.920 (est)
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Safety

Hazard Codes 
T+,T
Risk Statements 
26/27/28-63
Safety Statements 
28-36/37-45
RIDADR 
UN 1544 6.1/PG 2
WGK Germany 
3
RTECS 
HA5360000
F 
10
HazardClass 
6.1(a)
PackingGroup 
I
HS Code 
29349990
Hazardous Substances Data
36011-19-5(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H310Fatal in contact with skin

H330Fatal if inhaled

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P350IF ON SKIN: Gently wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C2149
Product name
Cytochalasin E from Aspergillus clavatus
Packaging
1mg
Price
$275
Updated
2022/05/15
Sigma-Aldrich
Product number
C2149
Product name
Cytochalasin E from Aspergillus clavatus
Packaging
5mg
Price
$1080
Updated
2022/05/15
Cayman Chemical
Product number
11331
Product name
Cytochalasin E
Purity
≥98%
Packaging
1mg
Price
$67
Updated
2024/03/01
Cayman Chemical
Product number
11331
Product name
Cytochalasin E
Purity
≥98%
Packaging
5mg
Price
$266
Updated
2024/03/01
Cayman Chemical
Product number
11331
Product name
Cytochalasin E
Purity
≥98%
Packaging
10mg
Price
$498
Updated
2024/03/01
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CYTOCHALASIN E Chemical Properties,Usage,Production

Description

The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin E is an epoxide-containing analog of cytochalasin B which potently and selectively inhibits the growth of endothelial cells (IC50 < 1 nM), impairing angiogenesis and tumor growth. This cytochalasin does not inhibit glucose transport or HIV-1 protease activity.

Chemical Properties

white powder

Uses

Cytochalasin E is one of a family of potent mycotoxins produced by a range of fungi. All members of the class exhibit profound effects on cytoskeletal proteins, resulting in pronounced morphogenic changes in animals and plants. Despite the common mode of action, there is evidence that individual members display diverse selectivity. Specifically, cytochalasin E acts as an angiogenesis inhibitor and, unlike other cytochalasins, does not inhibit glucose transport.

Uses

Cytochalasin E is a fungal metabolite which has been shown to exhibit antimicrobial and antibacterial effects. Cytochalasin E is a microfilament inhibitor enhancing the low-affinity Fc epsilon receptor (CD23) expression.

Uses

Cytochalasin E has been used as:

  • a toxin to study its effects on avocado plants
  • a component of the incubating medium in feline junctional adhesion molecule 1 (fJAM-1) expression assay
  • an inhibitor of actin polymerization to study its effects on mitochondria uptake by mice endothelial cells

Definition

ChEBI: A natural product found in Arthrinium sacchari.

Biochem/physiol Actions

Cytochalasin E is an epoxide that exhibits anti-proliferative activity in endothelial cells in vitro. It also participates in inhibiting tumor growth and angiogenesis in vivo. Cytochalasin E also possesses antimicrobial and antiviral properties.

CYTOCHALASIN E Preparation Products And Raw materials

Raw materials

Preparation Products

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CYTOCHALASIN E Suppliers

Australia 1 Belgium 1 China 53 Germany 4 India 1 Japan 1 Switzerland 2 United Kingdom 10 United States 22 Global 95
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
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86-10-82849933
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jkinfo@jkchemical.com
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China
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96815
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Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4727
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Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
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China
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51456
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Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
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Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
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China
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27313
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Beijing Solarbio Science & Tecnology Co., Ltd.
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010-50973130 4009686088
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3193328036@qq.com
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China
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29785
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Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
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China
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12306
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Anhui kuer Bioengineering Co., Ltd
Tel
0551-65171243 13856024262
Email
kuer@kuerhuaxue.com
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China
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2997
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55
Lynnchem
Tel
86-(0)29-85992781 17792393971
Email
info@lynnchem.com
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China
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4587
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Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
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36011-19-5, CYTOCHALASIN ERelated Search:

CYTOCHALASIN B, DIHYDRO cytochalasi CYTOCHALASIN D CYTOCHALASIN C CYTOCHALASIN A (R)-(-)-1-Amino-2-propanol TRANS-3-HEXEN-1-OL 2-AMINOHEPTANE TERT-AMYL METHYL ETHER N-(2-METHOXYETHYL)METHYLAMINE 4-(N-BUTYLAMINO)-1-BUTANOL isobutoxypropanol 4-AMINO-2-BUTANOL 2-METHOXY-2-METHYL-PROPYLAMINE N-SEC-BUTYL-N-PROPYLAMINE (S)-2-Aminooctane 2,3-EPOXY-2-METHYLBUTANE 2-AZACYCLONONANONE

  • (7S,13E,16S,18R,19E)-6,7-Epoxy-18-hydroxy-16,18-dimethyl-10-phenyl-21,23-dioxa[13]cytochalasa-13,19-diene-1,17,22-trione
  • [7β,13E,16S,18R,19E]-6,7-Epoxy-18-hydroxy-16,18-dimethyl-10-phenyl-21,23-dioxa[13]cytochalasa-13,19-diene-1,17,22-trione
  • (7s,13e,16s,18r,19e)-18-dimethyl-10-phenyl
  • 21,23-dioxa(13)cytochalasa-13,19-diene-1,17,22-trione,6,7-epoxy-18-hydroxy-16,
  • 6,7-epoxy-10-phenyl-5,6,16,18-tetramethyl-21,23-dioxa-[13]cytochalas-13,19-die
  • CYTOCHALASIN 3
  • CYTOCHALASIN E
  • CYTOCHALASIN E, ASPERGILLUS CLAVATUS
  • 1,3Dioxacyclotridecino4,5-doxirenofisoindole-5,10,12(4H,6H)-trione, 3,13,14,14a,15,15a,16a,16b-octahydro-6-hydroxy-4,6,15,15a-tetramethyl-14-(phenylmethyl)-, (1E,4S,6R,7E,11aS,14S,14aS,15S,15aR,16aS,16bS)-
  • CYTOCHALASIN E(RG)
  • CYTOCHALASIN E(RG) Please Call
  • CYTOCHALACINE
  • CYTOCHALICINE
  • LAJXCUNOQSHRJO-DXUWGLIISA-N
  • Cytochalasin E, 99%, from Aspergillus clavatus
  • 21,23-Dioxa[13]cytochalasa-13,19-diene-1,17,22-trione, 6,7-epoxy-18-hydroxy-16,18-dimethyl-10-phenyl-, (7S,13E,16S,18R,19E)-
  • CYTOCHALASIN E FROM ASPERGILLUSCLAVATUS
  • CYTOCHALASIN E FROM ASPERGILLUS &
  • CYTOCHALASIN E USP/EP/BP
  • Cytochalasin E, actin-polymerization inhibitor
  • 36011-19-5
  • C28H33N1O7
  • C28H33NO7
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Actin Inhibitors and Probes
  • BioChemical
  • Cytoskeleton and Extracellular Matrix
  • antibiotic
  • Actin Inhibitors and ProbesCell Signaling and Neuroscience
  • Cell Signaling and Neuroscience
  • Cytoskeleton and Extracellular Matrix
  • Mold
  • Toxins and Venoms