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MITOQ

Product Name
MITOQ
CAS No.
444890-41-9
Chemical Name
MITOQ
Synonyms
MitoQ10;Mitoquinol(MITOQ);Mitoquinone (Mito-Q;Mitoquinone Discontinued;Mitoquinone | Mitochondria-targeted antioxidant
CBNumber
CB73480165
Molecular Formula
C37H44O4P+
Formula Weight
583.73
MOL File
444890-41-9.mol
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MITOQ Property

storage temp. 
-20°
solubility 
Soluble in DMSO (70 mg/mL); ethanol (30 mg/mL)
form 
waxy solid
color 
Brown
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
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Hazard and Precautionary Statements (GHS)

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MITOQ Chemical Properties,Usage,Production

Description

Mitoquinone (444890-40-9) is a mitochondria-targeted antioxidant. Displays cardio- and neuroprotective effects.1?Displays beneficial effects in mouse models of Alzheimer’s disease.2?Mitoquinone protects pancreatic β-cells against oxidative stress and improves insulin secretion.3 Cell permeable.? Mesylate salt (Cat# 10-3914)and mesylate cyclodextrin complex (Cat# 10-3915) are also available.

Uses

Mitoquinone is a mitochondria-targeted antioxidant.

References

1) Ghosh et al. (2010), Neuroprotection by a mitochondria-targeted drug in a Parkinson’s disease model; Free Radic. Biol. Med., 49 1674 2) McManus et al. (2011), The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease; J. Neurosci., 31 15703 3) Lim et al. (2011), Mitochondria-targeted antioxidants protect pancreatic β-cells against oxidative stress and improve insulin secretion in glucotoxicity and glucolipotoxicity; Cell Physiol. Biochem., 28 873 4) Demers-Lamarche et al. (2016) Loss of Mitochondrial Function Impairs Lysosomes; J. Biol. Chem. 291 10263 [Focus Citation] 5) Zhou et al. (2018) Mitochondrial-targeted antioxidant MitoQ provides neuroprotection and reduces neuronal apoptosis in experimental traumatic brain injury possibly via the Nrf2-ARE pathway; Am. J. Transl. Res., 10 1887 [Focus Citation] 6) Xiao et al. (2017) The mitochondrial-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1; Redox Biol., 11 297 [Focus Citation] 7) Deng et al. (2019), Myo-inositol oxygenase expression profile modulates pathogenic ferroptosis in the renal proximal tubule; J. Clin. Invest., 129 5033 [Focus Citation]

MITOQ Preparation Products And Raw materials

Raw materials

Preparation Products

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MITOQ Suppliers

TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
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United States
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32161
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58
Focus Biomolecules
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Email
sales@focusbiomolecules.com
Country
United States
ProdList
1284
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58
Abcam
Tel
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Fax
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Email
us.orders@abcam.com
Country
United States
ProdList
6000
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AstaTech, Inc
Tel
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Email
sales@astatechinc.com
Country
United States
ProdList
6371
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444890-41-9, MITOQRelated Search:


  • Mitoquinone | Mitochondria-targeted antioxidant
  • Mitoquinol(MITOQ)
  • MitoQ10
  • Mitoquinone Discontinued
  • Mitoquinone (Mito-Q
  • 444890-41-9